Benzo[a]pyrene-induced multigenerational changes in gene expression, behavior, and DNA methylation are primarily influenced by paternal exposure

Pandelides, Zacharias; Sturgis, M.C.; Thornton, Cammi; Aluru, Neelakanteswar; Willett, Kristine L.

doi:10.1016/j.taap.2023.116545

Cited by 8 publications

(1 citation statement)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Benzo[a]pyrene (B[a]P) is a ubiquitous environmental pollutant that has been associated with transgenerational health consequences in humans and animals (Booc et al, 2014;Pandelides et al, 2023;Wan et al, 2023). Here, we observed a B[a]P-AOP titled 'DNA methyltransferase inhibition leading to transgenerational effects (2)' (AOP: 341) having a cumulative WoE of 'Moderate' (Table S10) and taxonomical relevance to Daphnia magna (Table S2).…”

Section: Toxicity Pathway Linking B[a]p Exposure To Transgenerational...mentioning

confidence: 82%

Network-based investigation of petroleum hydrocarbons-induced ecotoxicological effects and their risk assessment

Sahoo,

Madgaonkar,

Chivukula

et al. 2024

Preprint

View full text Add to dashboard Cite

Petroleum hydrocarbons (PHs) are compounds composed mostly of carbon and hydrogen, originating from crude oil and its derivatives. PHs are primarily released into the environment through the diffusion of oils, resulting from anthropogenic activities like transportation and offshore drilling, and accidental incidents such as oil spills. Once released, these PHs can persist in different ecosystems and cause long-term detrimental ecological impacts. While the hazards associated with such PH contaminations are often assessed by the concentrations of total petroleum hydrocarbons in the environment, studies focusing on the risks associated with individual PHs are limited. Here, we leveraged different network-based frameworks to explore and understand the adverse ecological effects associated with PH exposure. First, we systematically curated a list of 320 PHs from published reports. Next, we integrated biological endpoint data from toxicological databases, and constructed a stressor-centric adverse outcome pathway (AOP) network linking 75 PHs with 177 ecotoxicologically-relevant high confidence AOPs within AOP-Wiki. Further, we relied on stressor-species network constructions, based on reported toxicity concentrations and bioconcentration factors data for 80 PHs and 28 PHs, respectively, and found that crustaceans are documented to be affected by many of these PHs. Finally, we utilized the aquatic toxicity data within ECOTOX to construct species sensitivity distributions for polycyclic aromatic hydrocarbons (PAHs) prioritized by the US EPA, and derived their corresponding hazard concentrations (HC05) that protect 95% of species in the aquatic ecosystem. Overall, this study highlights the importance of using network-based approaches and risk assessment methods to understand the PH-induced toxicities effectively.

show abstract

Section: Toxicity Pathway Linking B[a]p Exposure To Transgenerational...mentioning

confidence: 82%

Network-based investigation of petroleum hydrocarbons-induced ecotoxicological effects and their risk assessment

Sahoo,

Madgaonkar,

Chivukula

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

The Role of Oxidative Stress and DNA Hydroxymethylation in the Pathogenesis of Benzo[a]pyrene‐Impaired Reproductive Function in Male Mice

Gan,

Zhang,

Cai

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

Benzo[a]pyrene (BaP), a polycyclic aromatic hydrocarbon, is known to cause teratogenesis. Environmental exposure of BaP has led to wide public concerns due to their potential risk of reproductive toxicity. However, the exact mechanism is still not clear. We aimed to explore the alterations of oxidative stress and DNA hydroxymethylation during BaP‐impaired reproductive function. BALB/c mice were intragastrically administered with different doses of BaP (0.01, 0.1, and 1 mg/kg/day, once a day), while control mice were administered with corn coil. Then, the reproductive function, alterations of oxidative stress, DNA methylation, and DNA hydroxymethylation of testis tissues were evaluated. We found that BaP caused obvious histopathological damages of testis tissues. As for sperm parameters after BaP administration, testis weight and the rate of teratosperm were increased, as well as sperm count and motility were decreased. In mechanism, BaP upregulated HO‐1 and MDA levels and downregulated SOD and CAT activity and GSH content in testis tissues, indicating that oxidative stress was induced by BaP. Furthermore, a significant induction of hydroxymethylation and inhibition of methylation were observed in testis tissues after BaP exposure. Collectively, BaP‐induced oxidative stress and hydroxymethylation were involved in impairing reproductive function, which may be the mechanism of the male infertility.

show abstract

Carcinogenic Polycyclic Aromatic Hydrocarbons

Marques,

Murray,

Penning

2024

Reference Module in Biomedical Sciences

View full text Add to dashboard Cite

Benzo[a]pyrene-induced multigenerational changes in gene expression, behavior, and DNA methylation are primarily influenced by paternal exposure

Cited by 8 publications

References 70 publications

Network-based investigation of petroleum hydrocarbons-induced ecotoxicological effects and their risk assessment

Network-based investigation of petroleum hydrocarbons-induced ecotoxicological effects and their risk assessment

The Role of Oxidative Stress and DNA Hydroxymethylation in the Pathogenesis of Benzo[a]pyrene‐Impaired Reproductive Function in Male Mice

Carcinogenic Polycyclic Aromatic Hydrocarbons

Contact Info

Product

Resources

About