Benzo[ghi]perylene induces cellular dormancy signaling and endoplasmic reticulum stress in NL-20 human bronchial epithelial cells

Zaragoza-Ojeda, Montserrat; Torres-Flores, Ulises; Rodríguez-Leviz, Alejandra; Arenas-Huertero, Francisco

doi:10.1016/j.taap.2022.115925

Cited by 10 publications

(3 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, Factor 2 was defined as coal combustion. Factor 3 was dominated by Bghi and Ind, which are generated from incomplete gasoline combustion and are the markers of high traffic flow in cities (Zaragoza-Ojeda et al 2022 ). Therefore, Factor 3 was defined as gasoline emissions.…”

Section: Resultsmentioning

confidence: 99%

Long-Term Atmosphere Surveillance (2016–2021) of PM2.5-bound Polycyclic Aromatic Hydrocarbons and Health Risk Assessment in Yangtze River Delta, China

Yao²,

Meng

et al. 2023

Expo Health

View full text Add to dashboard Cite

Long-term atmospheric quality monitoring of fine particulate matter (PM 2.5 ) and PM 2.5 -bound polycyclic aromatic hydrocarbons (PAHs) was performed in Wuxi from 2016 to 2021. In total, 504 atmospheric PM 2.5 samples were collected, and PM 2.5 -bound 16 PAHs were detected. The PM 2.5 and ∑PAHs level decreased annually from 2016 to 2021, from 64.3 to 34.0 μg/m 3 and 5.27 to 4.22 ng/m 3 , respectively. The benzo[a]pyrene (BaP) levels of 42% of the monitoring days in 2017 exceeded the recommended European Union (EU) health-based standard of 1 ng/m 3 . Five- and six-ring PAHs were found, including benz[a]anthracene, benzo[k]fluoranthene (Bkf), BaP, and benzo[g,h,i]perylene, which were the dominant components (indicating a prominent petroleum, biomass, and coal combustion contribution) using molecular diagnostic ratios and positive matrix factorization analysis. Moreover, PM 2.5 and PAHs were significantly negatively associated with local precipitation over a period of six years. Statistically significant temporal and spatial distribution differences of PM 2.5 , and ∑PAHs were also found. The toxicity equivalent quotient (TEQ) of total PAHs was 0.70, and the TEQ of BaP (0.178) was the highest, followed by that of Bkf (0.090), dibenz[a,h]anthracene (Dah) (0.048), and indeno[1,2,3-cd]pyrene (0.034). The medians of the incremental lifetime cancer risk for long-term exposure to PAHs were 2.74E−8, 1.98E−8, and 1.71E−7 for children, teenagers, and adults, respectively, indicating that the carcinogenic risk of PAHs pollution in air was acceptable to local residents in this area. Sensitivity analysis revealed that BaP, Bkf, and Dah significantly contributed to carcinogenic toxicity. This research provides comprehensive statistics on the local air persistent organic pollutants profile, helps to identify the principal pollution source and compounds, and contributes to the prevention of regional air pollution. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s12403-023-00572-x.

show abstract

Section: Resultsmentioning

confidence: 99%

Long-Term Atmosphere Surveillance (2016–2021) of PM2.5-bound Polycyclic Aromatic Hydrocarbons and Health Risk Assessment in Yangtze River Delta, China

Yao²,

Meng

et al. 2023

Expo Health

View full text Add to dashboard Cite

show abstract

“…Placental expression of SGF29 was positively associated with maternal urinary concentrations of 1-OH-NAP and 2-OH-NAP in the combined and female stratified models. SGF29 encodes SAGA Complex associated factor 29, which is a chromatin reader that binds to H3k4me chromatin and mediates the recruitment of the SAGA complex ( Schram et al 2013 ) The SAGA complex is induced in response to endoplasmic reticulum stress ( Nagy Zita et al 2009 ) In vitro studies conducted in endothelial cells have shown that other PAH compounds including benzo[ ghi ]perylene and 1-nitropyrene can induced endoplasmic reticulum stress ( Andersson et al 2009 ; Zaragoza-Ojeda et al 2022 ). The endoplasmic reticulum is involved in the intra and extracellular transport of proteins and lipids.…”

Section: Discussionmentioning

confidence: 99%

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Paquette

Lapehn²,

Freije

et al. 2023

Environment International

View full text Add to dashboard Cite

“…Regarding individual PAHs, naphthalene, benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, Indeno(123cd)pyrene and dibenz(a,h)anthracene are classified as Group 1, 2A or 2B carcinogens by IARC (IARC Monographs 2010). Moreover, members like phenanthrene and benzo(ghi)perylene have been linked to cardiovascular and other systemic effects [ 7 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Gradients of PAH Concentrations in Greek Cities and Associated Exposure Impacts

Tsiodra,

Tavernaraki,

Grivas

et al. 2024

Toxics

View full text Add to dashboard Cite

To study the spatiotemporal variability of particle-bound polycyclic aromatic hydrocarbons (PAHs) and assess their carcinogenic potential in six contrasting urban environments in Greece, a total of 305 filter samples were collected and analyzed. Sampling sites included a variety of urban background, traffic (Athens, Ioannina and Heraklion), rural (Xanthi) and near-port locations (Piraeus and Volos). When considering the sum of 16 U.S. EPA priority PAHs, as well as that of the six EU-proposed members, average concentrations observed across locations during summer varied moderately (0.4–2.2 ng m−3) and independently of the population of each site, with the highest values observed in the areas of Piraeus and Volos that are affected by port and industrial activities. Winter levels were significantly higher and more spatially variable compared to summer, with the seasonal enhancement ranging from 7 times in Piraeus to 98 times in Ioannina, indicating the large impact of PAH emissions from residential wood burning. Regarding benzo(a)pyrene (BaP), an IARC Group 1 carcinogen and the only EU-regulated PAH, the winter/summer ratios were 24–33 in Athens, Volos, Heraklion and Xanthi; 60 in Piraeus; and 480 in Ioannina, which is afflicted by severe wood-burning pollution events. An excellent correlation was observed between organic carbon (OC) and benzo(a)pyrene (BaP) during the cold period at all urban sites (r2 > 0.8) with stable BaP/OC slopes (0.09–0.14 × 10−3), highlighting the potential use of OC as a proxy for the estimation of BaP in winter conditions. The identified spatiotemporal contrasts, which were explored for the first time for PAHs at such a scale in the Eastern Mediterranean, provide important insights into sources and controlling atmospheric conditions and reveal large deviations in exposure risks among cities that raise the issue of environmental injustice on a national level.

show abstract

Benzo[ghi]perylene induces cellular dormancy signaling and endoplasmic reticulum stress in NL-20 human bronchial epithelial cells

Cited by 10 publications

References 68 publications

Long-Term Atmosphere Surveillance (2016–2021) of PM2.5-bound Polycyclic Aromatic Hydrocarbons and Health Risk Assessment in Yangtze River Delta, China

Long-Term Atmosphere Surveillance (2016–2021) of PM2.5-bound Polycyclic Aromatic Hydrocarbons and Health Risk Assessment in Yangtze River Delta, China

Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

Spatiotemporal Gradients of PAH Concentrations in Greek Cities and Associated Exposure Impacts

Contact Info

Product

Resources

About