Benzo-α-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA

Wang, Hongmei; Huang, Chen; Taki, Faten; Zhang, Yanqiong; Dobbins, Dorothy L.; Li, Lin; Yan, Hongtao; Pan, Xiaoping

doi:10.1016/j.chemosphere.2015.08.031

Cited by 28 publications

(13 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In murine X-linked muscular dystrophy (mdx) mice, a immunity relevant enzyme, glucose-6-phosphate dehydrogenase, was targeted by miR-1 in response to oxidative stress (Cacchiarelli et al, 2010). In Caenorhabditis elegans, miR-1 was involved in the oxidative stress response induced by benzo-a-pyrene (Wu et al, 2015). From this point of view, our findings concerning the targeting and regulating relationship between tci-miR-1-3p and TCGSTM4 suggest another possibility: that tci-miR-1-3p may participate in antioxidative regulation in T. cinnabarinus.…”

Section: Discussionmentioning

confidence: 99%

A microRNA‐1 gene, tci‐miR‐1‐3p, is involved in cyflumetofen resistance by targeting a glutathione S‐transferase gene, TCGSTM4, in Tetranychus cinnabarinus

Zhang

Feng

et al. 2018

Insect Molecular Biology

View full text Add to dashboard Cite

microRNA-1 (miR-1) is a well-studied conservative microRNA (miRNA) involved in immune responses in mammals and insects. However, little is known about its role in pesticide resistance in arthropods. In this study, we found that a microRNA belong to miR-1 family (tci-miR-1-3p) was significantly down-regulated in a cyflumetofen-resistant strain (CYR) of Tetranychus cinnabarinus compared with its homologous susceptible strain (SS), indicating an involvement of miR-1 in cyflumetofen resistance in mites. One glutathione S-transferase (GST) gene (TCGSTM4, a mu class GST gene), a candidate target gene of tci-miR-1-3p, was found to be significantly down-regulated when tci-miR-1-3p was over-expressed. The specific interaction between tci-miR-1-3p and the target sequence in the 3' untranslated region of TCGSTM4 was confirmed. A decrease or increase in tci-miR-1-3p abundance through feeding miRNA inhibitors or mimics significantly increased or decreased TCGSTM4 expressions at the mRNA and protein levels, respectively. In addition, an over-expression of tci-miR-1-3p resulted in a decrease in the tolerance of T. cinnabarinus to cyflumetofen in both SS and CYR strains, and vice versa. After decreasing TCGSTM4 transcription via RNA interference, T. cinnabarinus became more sensitive to cyflumetofen in both resistant and susceptible mites, and the change in mortality was greater in CYR than that in SS. Moreover, the recombinant TCGSTM4 could significantly decompose cyflumetofen, indicating that TCGSTM4 is a functional gene responsible for cyflumetofen resistance in mites.

show abstract

Section: Discussionmentioning

confidence: 99%

A microRNA‐1 gene, tci‐miR‐1‐3p, is involved in cyflumetofen resistance by targeting a glutathione S‐transferase gene, TCGSTM4, in Tetranychus cinnabarinus

Zhang

Feng

et al. 2018

Insect Molecular Biology

View full text Add to dashboard Cite

show abstract

“…These results mirrored expression found in kidneys of elderly mice. In a study that used benzo-α-pyrene to induce oxidative stress in C. elegans , miR-1, miR-355, miR-50, miR-51, miR-58, miR-796, and miR-84 were found to have modified expression (Wu et al, 2015). These miRNAs may be involved in the regulation of SKiNhead-1, a transcription factor involved in antioxidant response element (ARE) regulation, and gamma-glutamine cysteine synthase heavy chain, an ARE (Wu et al, 2015).…”

Section: Mirna Synthesis/actionmentioning

confidence: 99%

“…In a study that used benzo-α-pyrene to induce oxidative stress in C. elegans , miR-1, miR-355, miR-50, miR-51, miR-58, miR-796, and miR-84 were found to have modified expression (Wu et al, 2015). These miRNAs may be involved in the regulation of SKiNhead-1, a transcription factor involved in antioxidant response element (ARE) regulation, and gamma-glutamine cysteine synthase heavy chain, an ARE (Wu et al, 2015). In a mouse model with oxidative liver injury induced by treatment with the anti-tuberclosis drug isoniazid, expression of miR-122 in tissue was significantly changed at days 3 and 5 (Wu et al, 2015).…”

Section: Mirna Synthesis/actionmentioning

confidence: 99%

“…These miRNAs may be involved in the regulation of SKiNhead-1, a transcription factor involved in antioxidant response element (ARE) regulation, and gamma-glutamine cysteine synthase heavy chain, an ARE (Wu et al, 2015). In a mouse model with oxidative liver injury induced by treatment with the anti-tuberclosis drug isoniazid, expression of miR-122 in tissue was significantly changed at days 3 and 5 (Wu et al, 2015). In a study of miRNAs expressed in oxidatively stressed hippocampal neurons in senescence accelerated mice, miR-329, miR-193b, miR-20a, miR-296, and miR-130b were found to be upregulated (Zhang et al, 2014).…”

Section: Mirna Synthesis/actionmentioning

confidence: 99%

See 1 more Smart Citation

Are microRNAs true sensors of ageing and cellular senescence?

Williams

Smith

Kumar

et al. 2017

Ageing Research Reviews

View full text Add to dashboard Cite

All living beings are programmed to death due to aging and age-related processes. Aging is a normal process of every living species. While all cells are inevitably progressing towards death, many disease processes accelerate the aging process, leading to senescence. Pathologies such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, cardiovascular disease, cancer, and skin diseases have been associated with deregulated aging. Healthy aging can delay onset of all age-related diseases. Genetics and epigenetics are reported to play large roles in accelerating and/or delaying the onset of age-related diseases. Cellular mechanisms of aging and age-related diseases are not completely understood. However, recent molecular biology discoveries have revealed that microRNAs (miRNAs) are potential sensors of aging and cellular senescence. Due to miRNAs capability to bind to the 3’ untranslated region (UTR) of mRNA of specific genes, miRNAs can prevent the translation of specific genes. The purpose of our article is to highlight recent advancements in miRNAs and their involvement in cellular changes in aging and senescence. Our article discusses the current understanding of cellular senescence, its interplay with miRNAs regulation, and how they both contribute to disease processes.

show abstract

“…miRNAs target many crucial genes and processes that are related to ageing and cellular senescence, including oxidative stress, mitochondrial dysfunction, tumor suppression, neurodegenerative diseases, DNA damage and telomere shortening, which makes miRNA a useful tool as biomarkers of ageing and ageing-related diseases (see reviews in Harries 2014; Williams et al 2017). For instance, miR-1 is implicated in oxidative stress and neurodegenerative diseases, and miR-34a regulates mitochondria dysfunction, tumor suppression and telomere shortening, all of which somehow contribute to the ageing process (Yamakuchi et al 2008;Yang et al 2013;Wu et al 2015). miRNA can be used as a biomarker and a pool of miRNA can be used as mediator of the ageing process.…”

Section: Mirna Functionmentioning

confidence: 99%

Progress and prospects of noncoding RNAs in insects

Xiao

et al. 2019

Journal of Integrative Agriculture

View full text Add to dashboard Cite

With the rapid development of high-throughput sequencing technology and bioinformatics algorithms, great progress has been made in the field of noncoding RNA (ncRNA) in the last decade. RNA molecules have been regarded only as a messenger between DNA and protein for decades, but now they have new roles in the biological process as ncRNAs. A growing number of ncRNAs have been identified in insects from the RNA-Seq data of small RNA libraries or transcriptomes. ncRNAs have varied regulatory functions at the epigenetic, transcriptional, or post-transcriptional levels, and participate in almost all types of biological processes. Here, we review the research progress of four kinds of ncRNAs, including microRNA (miRNA), Piwiinteracting RNA (piRNA), circular RNA (circRNA), and long noncoding RNA (lncRNA) in insects. The discovery, biogenesis mechanisms, and regulatory functions of these ncRNAs are presented here to provide a comprehensive understanding of insect ncRNAs and to promote the application of ncRNAs in insect pest control.

show abstract

Benzo-α-pyrene induced oxidative stress in Caenorhabditis elegans and the potential involvements of microRNA

Cited by 28 publications

References 49 publications

A microRNA‐1 gene, tci‐miR‐1‐3p, is involved in cyflumetofen resistance by targeting a glutathione S‐transferase gene, TCGSTM4, in Tetranychus cinnabarinus

A microRNA‐1 gene, tci‐miR‐1‐3p, is involved in cyflumetofen resistance by targeting a glutathione S‐transferase gene, TCGSTM4, in Tetranychus cinnabarinus

Are microRNAs true sensors of ageing and cellular senescence?

Progress and prospects of noncoding RNAs in insects

Contact Info

Product

Resources

About