Benzoate fraction from Gentiana rigescens Franch alleviates scopolamine-induced impaired memory in mice model in vivo

Li, Jing; Gao, Lijuan; Sun, Kaiyue; Xiao, Dan; Li, Wanyi; Xiang, Lan; Qi, Jianhua

doi:10.1016/j.jep.2016.08.001

Cited by 29 publications

(20 citation statements)

References 29 publications

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“…In this study, as anticipated, scopolamine administration significantly elevated lipid peroxidation (MDA) levels, indicating the induction of oxidative stress in mice. This alteration was effectively suppressed by SE-EE in both the hippocampus and cerebral cortex, which is consistent with the results of previous reports 44 , 45 . In general, cellular organisms retain an effective integrated antioxidant defence system comprised of enzymatic and non-enzymatic factors to safeguard tissue from the impact of oxidative stress 46 .…”

Section: Discussionsupporting

confidence: 93%

Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model

Karthivashan

Park

Kweon³

et al. 2018

Sci Rep

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The Salicornia europaea L. (SE) plant is a halophyte that has been widely consumed as a seasoned vegetable, and it has been recently reported to counteract chronic diseases related to oxidative and inflammatory stress. In this study, we performed an initial phytochemical analysis with in vitro biochemical tests and chromatographic profiling of desalted and enzyme-digested SE ethanol extract (SE-EE). Subsequently, we evaluated the anti-neuroinflammatory and ameliorative potential of SE-EE in LPS-inflicted BV-2 microglial cells and scopolamine-induced amnesic C57/BL6N mice, respectively. SE-EE possess considerable polyphenols and flavonoids that are supposedly responsible to improve its bio-efficacy. SE-EE dose-dependently attenuated LPS-induced inflammation in BV-2 cells, significantly repressed behavioural/cognitive impairment, dose-dependently regulated the cholinergic function, suppressed oxidative stress markers, regulated inflammatory cytokines/associated proteins expression and effectively ameliorated p-CREB/BDNF levels, neurogenesis (DCX stain), neuron proliferation (Ki67 stain) in scopolamine-administered mice. Thus, SE-EE extract shows promising multifactorial disease modifying activities and can be further developed as an effective functional food, drug candidate, or supplemental therapy to treat neuroinflammatory mediated disorders.

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Section: Discussionsupporting

confidence: 93%

Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model

Karthivashan

Park

Kweon³

et al. 2018

Sci Rep

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“…In this study, scopolamine-induced demented rats impaired recognition memory in the ORT, as demented rats explored both F and N objects similarly and were not able to discriminate between both objects. These results are in harmony with prior studies [ 36 ] [ 37 ].…”

Section: Discussionsupporting

confidence: 92%

Ameliorative Effect of Silymarin on Scopolamine-induced Dementia in Rats

El-Marasy¹,

Abd‐Elsalam²,

Ahmed-Farid³

2018

Open Access Maced J Med Sci

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AIM:This study aims to elucidate the possible ameliorative effect of silymarin on scopolamine-induced dementia using the object recognition test (ORT) in rats.METHODS:The study was extended to demonstrate the role of cholinergic activity, oxidative stress, neuroinflammation, brain neurotransmitters and histopathological changes in the anti-amnestic effect of silymarin in demented rats. Wistar rats were pre-treated with silymarin (200, 400, 800 mg/kg) or donepezil (10 mg/kg) orally for 14 consecutive days. Dementia was induced after the last drug administration by a single intraperitoneal dose of scopolamine (16 mg/kg). Then behavioural, biochemical, histopathological, and immunohistochemical analyses were then performed.RESULTS:Rats pre-treated with silymarin counteracted scopolamine-induced non-spatial working memory impairment in the ORT and decreased acetylcholinesterase (AChE) activity, reduced malondialdehyde (MDA), elevated reduced glutathione (GSH), restored gamma-aminobutyric acid (GABA) and dopamine (DA) contents in the cortical and hippocampal brain homogenates. Silymarin reversed scopolamine-induced histopathological changes. Immunohistochemical analysis showed that silymarin mitigated protein expression of the glial fibrillary acidic protein (GFAP) and nuclear factor kappa-B (NF-κB) in the brain cortex and hippocampus. All these effects of silymarin were similar to that of the standard anti-amnestic drug, donepezil.CONCLUSION:This study reveals that the ameliorative effect of silymarin on scopolamine-induced dementia in rats using the ORT maybe in part mediated by, enhancement of cholinergic activity, anti-oxidant and anti-inflammatory activities as well as mitigation in brain neurotransmitters and histopathological changes.

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“…CREB protein is a cellular transcription factor necessary for the late stage of long‐term potentiation (LTP) and required for hippocampus‐dependent long‐term memory formation. SCOP significantly down‐regulates the expression of CREB in the hippocampus (Li et al, ), and in this study, SCOP reduced the levels of Egr‐1, c‐Jun, and CREB protein in the hippocampus. We have now demonstrated for the first time that PPT can up‐regulate hippocampal expression of Egr‐1, c‐Jun, and CREB at protein level, but the definitive signaling pathways related to these effects needs further investigation.…”

Section: Discussionsupporting

confidence: 73%

Neuroprotective effects of 20(S)‐protopanaxatriol (PPT) on scopolamine‐induced cognitive deficits in mice

Lü

Dong

et al. 2018

Phytotherapy Research

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20(S)-protopanaxatriol (PPT), one of the ginsenosides from Panax ginseng, has been reported to have neuroprotective effects and to improve memory. The present study was designed to investigate the protective effect of PPT on scopolamine-induced cognitive deficits in mice. Male Institute of Cancer Research mice were pretreated with 2 different doses of PPT (20 and 40 μmol/kg) for 27 days by intraperitoneal injection, and scopolamine (0.75 mg/kg) was injected intraperitoneally for 9 days to induce memory impairment. Thirty minutes after the last pretreatment, the locomotor activity was firstly examined to evaluate the motor function of mice. Then, memory-related behaviors were evaluated, and the related mechanism was further researched. It was founded that PPT treatment significantly reversed scopolamine-induced cognitive impairment in the object location recognition experiment, the Morris water maze test, and the passive avoidance task, showing memory-improving effects. PPT also significantly improved cholinergic system reactivity and suppressed oxidative stress, indicated by inhibition of acetylcholinesterase activity, elevation of acetylcholine levels, increasing superoxide dismutase activity and lowering levels of malondialdehyde in the hippocampus. In addition, the expression levels of Egr-1, c-Jun, and cAMP responsive element binding in the hippocampus were significantly elevated by PPT administration. These results suggest that PPT may be a potential drug candidate for the treatment of cognitive deficit in Alzheimer's disease.

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Benzoate fraction from Gentiana rigescens Franch alleviates scopolamine-induced impaired memory in mice model in vivo

Cited by 29 publications

References 29 publications

Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model

Ameliorative potential of desalted Salicornia europaea L. extract in multifaceted Alzheimer’s-like scopolamine-induced amnesic mice model

Ameliorative Effect of Silymarin on Scopolamine-induced Dementia in Rats

Neuroprotective effects of 20(S)‐protopanaxatriol (PPT) on scopolamine‐induced cognitive deficits in mice

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