Benzochromenes from the roots of Bourreria pulchra

Inhibitory activity of benzo[h]quinoline and benzo[h]chromene in human glioblastoma cells

“…Literature survey has demonstrated the diversity of pharmacological applications of fused chromenes such as, anticancer [1,2], antibacterial [3], anti-inflammatory [4], antioxidants [5,6] and antiprotozoal [7] activities. Also, fused quinoline derivatives produce wide pharmacological activities such as antibacterial [8,9], antifungal [10], antimalarial [11], antiplasmodium [12] and anticancer [13,14] effects.…”

Reagent‐Controlled Cyclization–Deprotection Reaction to Yield either Fluorenes or Benzochromenes

“…6 H ‐Benzo[ c ]chromenes, e.g., 6,6‐dimethyl‐6 H ‐benzo[ c ]chromene ( 1 ), with various biological activities are abundant in nature. Examples include the antiprotozoal pulchrol ( 2 ),1 the antibacterial didehydroconicol ( 3 ),2 and the psychotropic cannabinol ( 4 ) 3. 9 H ‐Fluorene ( 5 )4 is a member of the polycyclic aromatic hydrocarbon (PAH) family, and some fluorenes such as 6 5 are carcinogens.…”

Total Synthesis of Pulchrol and Pulchral

“…化合物 13 与甲基锂经过亲核取 代, 在酸性条件下关环且脱保护得到化合物 1, 两步产 率 60%, 将化合物 1 氧化得到 2, 产率 80%. 苯并色烯 1 和 2 的光谱数据与天然产物相同 [5] .…”

“…通常在墨西哥尤卡坦半岛用作抗病毒和 解热剂, 也用于治疗皮肤疾病. Pulchrol (1)和 pulchral (2)(图 1)是从 Bourreria pulchra 的根提取物中分离出来 的两种苯并色烯类天然产物, 通过测定 1 和 2 的体外抗 虫活性发现, pulchrol (1)对利什曼原虫和克氏锥虫有显 著的抑制作用(IC 50 分别为 4.6 和 7.5 μg/mL) [5] .…”