Benzodiazepine and antipsychotic medication use in older adults

Neft, Michael; Oerther, Sarah; Halloway, Shannon; Hanneman, Sandra K.; Mitchell, Ann M.

doi:10.1002/nop2.425

Cited by 2 publications

(4 citation statements)

References 14 publications

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“…Já no idoso ocorre modificações em alguns processos, ocasionados pela baixa na massa magra, albumina, água corporal e pelo aumento do tecido adiposo (Danza et al, 2015), com todas essas mudanças a um aumento no volume de distribuição, diminuição do metabolismo e excreção dos BZDs (Neft et al, 2019;Dominguez, 2016).…”

Section: A Farmacocinética Dos Benzodiazepínicos Em Idososunclassified

“…Os BZDs estão associados a danos e efeitos adversos, porém a intensidade desses danos e efeitos podem variar de acordo com a concentração de pico e conforme a duração dos BZDs, além de que o envelhecimento torna os idosos mais sensíveis, podendo ter como causa uma redução de neurônios e respectivamente de receptores, tornando os receptores exposto por mais tempo a medicação (Lader, 2014), causando um nível de sedação maior do que o esperado, confusões mentais, fadiga e desempenho psicomotor com comprometimentos (Neft et al, 2019), como o aumento de riscos de quedas prejudiciais, com presença de lesões (Jiang et al, 2019) Cunha et al (2015, relataram que os BZDs mais utilizados foram Clonazepam, Diazepam, Alprazolam e Bromazepam.…”

Section: Toxicologia Dos Benzodiazepínicos Em Idososunclassified

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Dependência química induzida pelo uso de benzodiazepínicos na senescencia

Silva

Souza

2021

RSD

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Devido aos efeitos sedativos e tranquilizante os idosos utilizam por tempo além do recomendado, ocasionando muita das vezes efeitos indesejados, como é o caso da dependência. Em torno disso, o objetivo deste trabalho por meio de revisão, foi levantar as causas da toxicologia e dependência, além do entendimento sobre o manejo da retirada do fármaco. Metodologia: Foram utilizadas as plataformas SCIELO, LILICS, MEDLINE/PUBMED e livro, onde passaram por critérios de exclusão e inclusão, resultando em 35 estudos incluídos. Resultado e Discussão: Os BZDs são medicamentos no geral seguros, porém se utilizados por curtos prazos, sendo os mais recomendados para idosos a utilização de BZDs com meia vida curta. A grande parte da toxicologia são cognitivos e psicomotores, além da dependência. Para o manejo da dependência são utilizados a redução gradual ou auxilio com outras classes medicamentosas. Considerações finais: O presente estudo mostra de forma objetiva e clara a toxicologia nos idosos, dependência e manejo da dependência, sendo umas das dificuldades para o manejo o aparecimento de sintomas que se parecem com o retorno das causas para o início da terapia medicamentosa.

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Section: A Farmacocinética Dos Benzodiazepínicos Em Idososunclassified

Section: Toxicologia Dos Benzodiazepínicos Em Idososunclassified

Dependência química induzida pelo uso de benzodiazepínicos na senescencia

Silva

Souza

2021

RSD

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“…In the US alone, the total number of antipsychotics purchased in the general population increased 86% from 1997 to 2007 (17.4 million to 32.4 million purchases, respectively) [ 2 ]. This precipitous increase can be partially attributed to the emergence of second-generation antipsychotics in the 1990s, as well as an increase in the number of US Food and Drug Administration (FDA)-approved conditions for which psychopharmaceuticals can be prescribed [ 3 , 4 , 5 , 6 , 7 ]. Moreover, increases in the use of psychopharmaceuticals in children, as well as off-label and non-FDA-approved uses of these medications, have further contributed to increased use [ 8 , 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Health care providers prescribe psychopharmaceuticals to prevent neurodevelopmental disorders and reduce the risk of mental illness in their patients in a wide range of medical fields (e.g., pediatrics, obstetrics and gynecology (OB-GYN), geriatrics, and psychiatry) [ 6 , 10 , 13 ]. Of the many psychopharmaceuticals consumed by humans, selective serotonin reuptake inhibitors (SSRIs), or antidepressants, are of particular interest given their widespread use and well-documented effects on neurodevelopment [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Impacts of Psychopharmaceuticals on the Neurodevelopment of Aquatic Wildlife: A Call for Increased Knowledge Exchange across Disciplines to Highlight Implications for Human Health

Chan

Nutting

Natterson

et al. 2021

IJERPH

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The global use of psychopharmaceuticals such as antidepressants has been steadily increasing. However, the environmental consequences of increased use are rarely considered by medical professionals. Worldwide monitoring efforts have shown that pharmaceuticals are amongst the multitude of anthropogenic pollutants found in our waterways, where excretion via urine and feces is thought to be the primary mode of pharmaceutical contamination. Despite the lack of clarity surrounding the effects of the unintentional exposure to these chemicals, most notably in babies and in developing fetuses, the US Environmental Protection Agency does not currently regulate any psychopharmaceuticals in drinking water. As the underlying reasons for the increased incidence of mental illness—particularly in young children and adolescents—are poorly understood, the potential effects of unintentional exposure warrant more attention. Thus, although links between environmental contamination and physiological and behavioral changes in wildlife species—most notably in fish—have been used by ecologists and wildlife biologists to drive conservation policy and management practices, we hypothesize that this knowledge may be underutilized by medical professionals. In order to test this hypothesis, we created a hierarchically-organized citation network built around a highly-cited “parent” article to explore connections between aquatic toxicology and medical fields related to neurodevelopment. As suspected, we observed that studies in medical fields such as developmental neuroscience, obstetrics and gynecology, pediatrics, and psychiatry cite very few to no papers in the aquatic sciences. Our results underscore the need for increased transdisciplinary communication and information exchange between the aquatic sciences and medical fields.

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Benzodiazepine and antipsychotic medication use in older adults

Cited by 2 publications

References 14 publications

Dependência química induzida pelo uso de benzodiazepínicos na senescencia

Dependência química induzida pelo uso de benzodiazepínicos na senescencia

Impacts of Psychopharmaceuticals on the Neurodevelopment of Aquatic Wildlife: A Call for Increased Knowledge Exchange across Disciplines to Highlight Implications for Human Health

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