Benzodiazepines and related drugs for insomnia in palliative care

Análise clínica e terapêutica dos pacientes oncológicos atendidos no programa de dor e cuidados paliativos do Hospital Universitário Clementino Fraga Filho no ano de 2003

“…In this study, 27 patients presented delirium and 18 of those were treated with haloperidol. The sleep changes reported by patients were induced by psychological and physical factors, such as pain, dyspnea, and frequency of awakening at night to urinate or take medication [44][45][46][47] . Dyspnea was the most frequent respiratory symptom.…”

“…Vinte e sete pacientes deste estudo apresentaram delírio e 18 deles utilizaram haloperidol. A alteração do sono relatada pelos pacientes foi induzida por fatores psicológicos e físicos, tais como dor, dispnéia, freqüência do despertar durante a noite para urinar e o uso de medicamentos [44][45][46][47] . A dispnéia foi o sintoma respiratório mais encontrado.…”

Transdermal Absorption of (−)-Linalool Induces Autonomic Deactivation but has No Impact on Ratings of Well-Being in Humans

“…As a consequence, prescriptions for sedative drugs, especially tranquillizers and hypnotics of the benzodiazepine receptor agonist type, have increased dramatically (de las Cuevas et al, 2003;Hirst and Sloan, 2002). Since these drugs are associated with serious adverse effects, for example, rebound and hang-over effects, reduced alertness and efficiency during the day as well as physical and psychic addiction, chronic intake of these substances is somewhat problematic.…”

Control de los síntomas neuropsicológicos

“…El tratamiento farmacológico se resume en la tabla 4. Aunque las benzodiacepinas de vida media corta, incluyendo entre ellas el zolpidem y la zoplicona, son los fármacos de elección, no disponemos de estudios concluyentes en pacientes con cáncer avanzado 31 . En cualquier caso, se debe tener especial precaución con el efecto rebote.…”