Benzodiazepines and Related Drugs in Orthopaedics

Hozack, Bryan A.; Kistler, Justin M.; Vaccaro, Alexander R.; Beredjiklian, Pedro K.

doi:10.2106/jbjs.22.00516

Cited by 6 publications

(1 citation statement)

References 65 publications

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“…The use of Xanax prior to surgery may have obscured some of the anxiolytic benefits of the procedure. (25) This may explain why no anxiety changes were observed on the day of surgery. Moreover, blood pressure was controlled with medication.…”

Section: Discussionmentioning

confidence: 99%

Effects of Therapeutic Advice and Patient Education on Anxiety and Satisfaction in Patients Undergoing Cataract Surgery; A Randomized Controlled Trial

Anwaar¹,

Sajjad²,

Mustafa³

et al. 2022

PJMHS

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Background: Anxiety and fear are the most prevalent and most reported negative aspects associated with cataract surgery. However, it is difficult to determine the frequency of patients experiencing it. The data vary depending on the phase of procedure, study group and ophthalmic centre. Proper patient education as well as therapeutic advice may assist in reducing these adverse effects and improving clinical satisfaction and outcomes. Objective: To determine the effects of therapeutic advice and patients’ education on anxiety and satisfaction in patients undergoing cataract surgery. Methods: This was a randomized controlled trial. The study was carried out during the months of January and June of 2021 at Link Medical Centre Lahore. Participants were chosen from list of patients who expressed interest in having cataract surgery. Patients over the age of 17 who were able to understand and communicate, who had not previously had cataract surgery, and who did not suffer from hearing loss were considered suitable. The outcomes used were Calmness scale (1-7), Cooperativeness (1-7), State-Trait Anxiety Inventory (STAI) - Trait Anxiety, low vision quality-of-life questionnaire (LVQoL), Wellbeing (1-9) Results: The results showed that there were 15(65.21%) females in experimental and 16(69.56%) in control group. The mean age and standard deviation were found to be 69.98 (9.7) and 73.14 (14.46) in experimental and control group. The assessment conducted after intervention showed mean and standard deviation respectively in experimental and control group to be as Calmness (1-7), 6.8 (3.7) and 4.8 (2.3), Cooperativeness (1-7), 6.9 (1.2) and 5.3 (3.4), STAI - Trait Anxiety 24.8 (3.69) and 33.9 (2.36), LVQoL, 113.6 (6.8) and 88.6 (4.3), Wellbeing (1-9), 8.4 (2.12) and 7.3 (1.87), while there was significant difference in favour of experimental group (p value < 0.05) in all variables after surgical procedure. Conclusion: The study shows that there were significant effects of therapeutic advice and patient education in favour of intervention group on patients’ anxiety and satisfaction in patients undergoing cataract surgery. More research needs to be done on how well each part works on its own, and more intervention presentations are needed to figure out how well combination therapy works for lowering anxiety. Keywords: Cataract Surgery, Patient Education, Satisfaction, Anxiety, Therapeutic Advice, Nutritional Status

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Section: Discussionmentioning

confidence: 99%

Effects of Therapeutic Advice and Patient Education on Anxiety and Satisfaction in Patients Undergoing Cataract Surgery; A Randomized Controlled Trial

Anwaar¹,

Sajjad²,

Mustafa³

et al. 2022

PJMHS

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Anxiolytic Efficacy of Indirubin: In Vivo Approach Along with Receptor Binding Profiling and Molecular Interaction with GABAergic Pathways

Disha,

Hasan,

Bhuia

et al. 2024

ChemistryOpen

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Anxiety is a natural response to stress, characterized by feelings of worry, fear, or unease. The current research was conducted to investigate the anxiolytic effect of indirubin (IND) in different behavioral paradigms in Swiss albino mice. To observe the animal's behavioural response to assess anxiolytic activity, different tests were performed, such as the open‐field (square cross, grooming, and rearing), swing, dark‐light, and hole cross tests. The experimental mice were administered IND (5 and 10 mg/kg, p.o.), where diazepam (DZP) and vehicle were used as positive and negative controls, respectively. In addition, a combination treatment (DZP+IND‐10) was provided to the animals to determine the modulatory effect of IND on DZP. Molecular docking approach was also conducted to determine the binding energy of IND with the GABAA receptor (α2 and α3 subunits) and pharmacokinetics were also estimated. The findings revealed that IND dose‐dependently significantly (p<0.05) reduced the animal's movement exerting calming behavior like DZP. IND also demonstrated the highest docking score (−7.7 kcal/mol) against the α3 subunit, while DZP showed a lower docking value (−6.4 kcal/mol) than IND. The ADMET analysis revealed that IND has proper drug‐likeness and pharmacokinetic characteristics. In conclusion, IND exerted anxiolytic effects through GABAergic Pathways.

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