Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action

Zoroufchi, Babak Hosseinzadeh; Doustmohammadi, Hoda; Mokhtari, Tahmineh; Abdollahpour, Abolfazl

doi:10.1016/j.androl.2019.08.003

Cited by 7 publications

(5 citation statements)

References 65 publications

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“…To the contrary, increased desire or sexual disinhibition was commonly found when low-dose benzodiazepines were used. 25 26 Thus, though lower dosages of benzodiazepines seem to promote sexual function, sexual dysfunction becomes more common with increasing dosages of benzodiazepines, as reported in our study; determining the safe dosage of benzodiazepines for sexual dysfunction prevention is worth studying. Interestingly, a greater proportion of those having sexual dysfunction in our study used antipsychotic agents, but this finding did not reach statistical significance.…”

Section: Discussionsupporting

confidence: 55%

“… 23 Some substances of abuse, methamphetamine in particular, could enhance sexual pleasure and might be used as self-medication for sexual dysfunction. 24 The effect of alcohol, which shares a similar pathway with benzodiazepines, impacted sexual health bidirectionally, 25 26 and the exact effects of such substances in clinical settings were hard to conclude. Therefore, further studies are needed.…”

Section: Discussionmentioning

confidence: 99%

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Sexual dysfunction and associated factors in Thai patients with psychiatric disorders

2023

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BackgroundSexual dysfunction is common among patients with psychiatric disorders but might be under-reported due to Asian sociocultural factors. Recognition of sexual dysfunction and associated factors in this vulnerable population would help clinicians properly assess and manage related conditions.AimsWe aimed to examine the prevalence of sexual dysfunction and its associated factors among patients with psychiatric disorders in Thailand.MethodsThis was a cross-sectional study. We enrolled participants aged 18 and older who visited the psychiatry clinic at King Chulalongkorn Memorial Hospital in Bangkok, Thailand between August 2020 and December 2021. Demographic and clinical data were assessed, and all psychiatric disorders and sexual dysfunctions were diagnosed by clinical interview using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Statistical analysis was done to explore the association between sexual dysfunction and related factors.ResultsSexual dysfunction was diagnosed in 101 (50.0%) of the total 202 participants. The mean (standard deviation, SD) age was 30.2 (9.0) years, and the majority of patients were men (54.5%), single (81.2%), employed (47.5%) and had a coexisting depressive disorder (48.0%). Multivariable logistic regression analysis showed a significant association between sexual dysfunction and quality of life, unemployment, and the dosage of antidepressants and benzodiazepines.ConclusionsThe prevalence of sexual dysfunction among this population was relatively high. However, the findings may represent only a portion of affected psychiatric patients for others with sexual dysfunction symptoms but without functional impairment did not meet the diagnostic criteria for sexual dysfunction. Improvement of quality of life and optimising antidepressant/benzodiazepine dosage should be further investigated for promoting sexual function in patients with mental disorders.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Sexual dysfunction and associated factors in Thai patients with psychiatric disorders

2023

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“…However, several side effects, e.g., sexual dysfunction, cardiovascular disease, and osteoporosis, have been reported for these antidepressants [15,16]. Recently, the relationship between thyroid axis abnormalities and psychiatric disorders has been proven [17].…”

Section: Introductionmentioning

confidence: 99%

Intraventricular T3 Reverses Chronic Restraint Stress-Induced Depressive-Like Behaviors: Inhibition of NF-κB/ NLRP3 Inflammasome Pathway in the Hippocampus

Mokhtari

El-Kenawy

2021

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In this study, the effects of triiodothyronine (T3) were evaluated on the NLRP3 inflammasome complex formation in the hippocampus of the rat with restraint stress-induced depressive-like behaviors.Thirty-six Wistar male rats were randomly allocated to the following groups: Control, Model, and Model + T3. In Model or Model + T3 group, a single dose of PBS or T3 () was administered into the lateral ventricle. Depressive-like behaviors were induced by chronic restraint stress. The forced swimming (FST), tail suspension (TST), and open field (OFT) tests were used to investigate depression. The rats were sacrificed, and brain tissues were stored for molecular and pathological evaluations. Chronic stress increased the immobility of rats in the Model group according to FST, TST, and OFT (P < 0.05). T3 significantly improved depressive-like behaviors (P < 0.05). The gene expression and protein level of hippocampal NF-κB, NLRP3, ASC, and Caspase-1 significantly increased in the Model group compared to the control group (P < 0.05). The reduced hippocampal levels of NF-κB, NLRP3, ASC, and Caspase-1 were seen in the T3 group compared to the Model group (P < 0.05). Also, the Nissl staining of the CA1 region showed an increased number of dark neurons (P < 0.05) and reduced pyramidal layer thickness (P < 0.05) in the Model group. These histopathological alterations were changed by T3 administration compared to the Model group (P < 0.05). The findings of confirmed the therapeutic effects of intraventricularly T3 on depressive-like behaviors induced by restraint stress via surviving pyramidal neurons of the CA1 region and inhibition of NF-κB/NLRP3 inflammasome pathway.

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“…Different classes of antidepressants have been developed based on the hypothesis that depression, as a neuroendocrine disorder, result from an imbalance in the monoamine neurotransmitters [14]. However, several side effects, e.g., sexual dysfunction, cardiovascular disease, and osteoporosis, have been reported for these antidepressants [15,16]. Recently, the relationship between thyroid axis abnormalities and psychiatric disorders has been proven [17].…”

Section: Introductionmentioning

confidence: 99%

Intraventricular T3 reverses chronic restraint stress-induced depressive-like behaviors: Inhibition of NF-κB/ NLRP3 inflammasome pathway in the hippocampus

Mokhtari

El-Kenawy

2021

Preprint

Self Cite

View full text Add to dashboard Cite

In this study, the effects of triiodothyronine (T3) were evaluated on the NLR family pyrin domain containing 3 (NLRP3) inflammasome complex formation in the rat's hippocampus with restraint stress-induced depressive-like behaviors.Thirty-six Wistar male rats were randomly allocated to following groups: Control, Model, and Model + T3. In the Model or Model+T3 group, a single dose of PBS or T3 was administered into the lateral ventricle. Depressive-like behaviors were induced by chronic restraint stress. The forced swimming (FST), tail suspension (TST), and open field (OFT) tests were used to investigate the depression. The rats were sacrificed, and brain tissues were stored for molecular and pathological evaluations. Chronic stress increased the immobility of rats in the Model group according to FST, TST, and OFT (P < 0.05). T3 significantly improved depressive-like behaviors (P < 0.05). The gene expression and protein level of hippocampal nuclear factor kappa B (NF-κB), NLRP3, apoptosis-associated speck-like protein (ASC), and Caspase-1 significantly increased in the Model group compared to the control group (P < 0.05). The reduced hippocampal levels of NF-κB, NLRP3, ASC, and Caspase-1 were observed in the T3 group compared to the Model group (P < 0.05). The Nissl staining of the CA1 region showed an increased number of dark neurons (P < 0.05) and reduced pyramidal layer thickness (P < 0.05) in the Model group. These histopathological alterations were changed by T3 administration compared to the Model group (P < 0.05). The findings confirmed the therapeutic effects of intraventricularly T3 on depressive-like behaviors induced by restraint stress via surviving pyramidal neurons of the CA1 region and inhibition of NF-κB/NLRP3 inflammasome pathway.

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Benzodiazepines related sexual dysfunctions: A critical review on pharmacology and mechanism of action

Cited by 7 publications

References 65 publications

Sexual dysfunction and associated factors in Thai patients with psychiatric disorders

Sexual dysfunction and associated factors in Thai patients with psychiatric disorders

Intraventricular T3 Reverses Chronic Restraint Stress-Induced Depressive-Like Behaviors: Inhibition of NF-κB/ NLRP3 Inflammasome Pathway in the Hippocampus

Intraventricular T3 reverses chronic restraint stress-induced depressive-like behaviors: Inhibition of NF-κB/ NLRP3 inflammasome pathway in the hippocampus

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