Benzopyranyl Phosphonate and β‐Phosphono Malonates Derivatives: An Exciting Breakthrough in Chemistry

Abstract

In this review, we paid attention to the reported methods and recent advances in the development of 2-amino-3-cyano-4Hchromen-4-yl-phosphonates and functionalized β-phosphonomalonates heterocyclic compound. Small-molecular architectures are considered with the highlighting on their structural design and synthesis approach. The scope of the 2-amino-3-cyano-4H-chromen-4-yl-phosphonates and functionalized βphosphonomalonates heterocyclic compound via reactions like Knoevenagel, Pinner-cyclisation and advanced phospha-Michael addition reactions using different catalyst for synthesis is listed up to 2020.

PMDTA-catalyzed multicomponent synthesis and biological activity of 2-amino-4H-chromenes containing a phosphonate or phosphine oxide moiety

“…malononitrile or ethyl cyanoacetate) and dialkyl-or trialkyl phosphites. 10 Most procedures utilizing the above synthesis route were carried out in the presence of both a catalyst and a solvent. Diethylamine, 11 dibutylamine, 7 triethylamine, 12 dimethylaminopyridine, 13 imidazole, 14 ethylenediamine diacetate, 15 lithium hydroxide, 16 potassium phosphate, 17 magnesium oxide 18 or indium chloride 19 were tried out in ethanol, and iron oxide, 20 iodine 21 or β-cyclodextrin 22 in water.…”