“…It facilitates numerous reactions including the Suzuki-Miyaura cross-coupling reaction, the epoxidation of cis -Cyclooctene, transamidation of carboxamide with primary amines, ethylene oligomerization, and intramolecular cyclization. ( Gafurov et al, 2021 , Vijayapritha and Viswanathamurthi, 2020 , Wang et al, 2016 , Wang et al, 2018 ). Fig.…”
“…It facilitates numerous reactions including the Suzuki-Miyaura cross-coupling reaction, the epoxidation of cis -Cyclooctene, transamidation of carboxamide with primary amines, ethylene oligomerization, and intramolecular cyclization. ( Gafurov et al, 2021 , Vijayapritha and Viswanathamurthi, 2020 , Wang et al, 2016 , Wang et al, 2018 ). Fig.…”
“…All this provokes a considerable interest in a benzothiazole scaffold for the design of new metal-based pharmaceuticals. Curiously, transition metal pincer complexes bearing a benzothiazole unit (see, for example, compounds I-VIII in Figure 1) are largely explored for luminescence properties, electrochemical behavior, and catalytic activity in different reactions [29][30][31][32][33][34][35] but have rarely been tested for their biological effects (for selected reports, see Refs. [36][37][38]).…”
Driven by the growing threat of cancer, many research efforts are directed at developing new chemotherapeutic agents, where the central role is played by transition metal complexes. The proper ligand design serves as a key factor to unlock the anticancer potential of a particular metal center. Following a recent trend, we have prepared unsymmetrical pincer ligands that combine benzothiazole and thiocarbamate donor groups. These compounds are shown to readily undergo direct cyclopalladation, affording the target S,C,N-type Pd(II) pincer complexes both in solution and in the absence of a solvent. The solid-phase strategy provided the complexes in an efficient and ecologically friendly manner. The resulting palladacycles are fully characterized using nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy and, in one case, by single-crystal X-ray diffraction (XRD). The solvent-free reactions are additionally analyzed by powder XRD. The pincer complexes exhibit remarkable cytotoxicity against several solid and blood cancer cell lines, including human colorectal carcinoma (HCT116), breast cancer (MCF7), prostate adenocarcinoma (PC3), chronic myelogenous leukemia (K562), multiple plasmacytoma (AMO1), and acute lymphoblastic leukemia (H9), with the dimethylamino-substituted derivative being particularly effective. The latter also induced an appreciable level of apoptosis in both parental and doxorubicin-resistant cells K562 and K562/iS9, vindicating the high anticancer potential of this type of palladacycles.
“…Our research team has been focusing on the design, synthesis, and catalytic application of pincer-type ligands and their complexes of group 10 metals during the past few years [41][42][43][44][45][46][47]. The intrinsic diamagnetism of this metal ions in d 8 configuration allows for fine assignment of the electronic structure of the oxidized species.…”
A Pt(II) complex bearing chelating tridentate bis-aryloxide tetrahydropyrimidinium-based N-heterocyclic carbene (NHC) was synthesized and characterized by using different techniques. Both cyclic voltammetry and differential pulse voltammetry were used to study the electrochemical properties of the complex, revealing two reversible one-electron oxidation processes. The chemical generation and isolation of one-electron-oxidized species were performed oxidizing the initial complex by means of AgBF4. A combination of spectroscopic (UV-Vis/NIR- and EPR-) and theoretical (density functional theory (DFT)) studies suggests the formation of a Pt(II)-phenoxyl radical complex. The latter open-shell derivative was structurally characterized by means of X-ray diffraction analysis. Finally, the neutral platinum complex was tested as a mediator in the process of electrocatalytic oxidation of 2-(methylamino)ethanol (MEA).
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