Benzoxazinoids from Scoparia dulcis (sweet broomweed) with antiproliferative activity against the DU-145 human prostate cancer cell line

Wu, Wan-Hsun; Chen, Tzu‐Yu; Lu, Rui-Wen; Chen, Shui‐Tein; Chang, Chia-Chuan

doi:10.1016/j.phytochem.2012.07.022

Cited by 51 publications

(43 citation statements)

References 32 publications

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“…In planta benzoxazinoids exhibit strong bioactivity, such as allelopathic potency (10,11). Several in vitro studies were conducted to elucidate various bioactivities of benzoxazinoids, including antiproliferative, aneugenic, and anti-inflammatory effects (12)(13)(14)(15), but their potential impact as dietary compounds is so far not known.…”

Section: Introductionmentioning

confidence: 99%

The Postprandial Plasma Rye Fingerprint Includes Benzoxazinoid-Derived Phenylacetamide Sulfates

Hanhineva

Keski‐Rahkonen

Lappi

et al. 2014

The Journal of Nutrition

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The bioavailability of whole-grain rye-derived phytochemicals has not yet been comprehensively characterized, and different baking and manufacturing processes can modulate the phytochemical composition of breads and other rye products. The aim of our study was to find key differences in the phytochemical profile of plasma after the consumption of 3 breads containing rye bran when compared with a plain white wheat bread control. Plasma metabolite profiles of 12 healthy middle-aged men and women were analyzed using LC quadrupole time-of-flight mass spectrometry metabolomics analysis while fasting and at 60 min, 120 min, 240 min, and 24 h after consuming a meal that contained either 100% whole-grain sourdough rye bread or white wheat bread enriched with native unprocessed rye bran or bioprocessed rye bran. White wheat bread was used as the control. The meals were served in random order after a 12-h overnight fast, with at least 3 d between each occasion. Two sulfonated phenylacetamides, hydroxy-N-(2-hydroxyphenyl) acetamide and N-(2-hydroxyphenyl) acetamide, potentially derived from the benzoxazinoid metabolites, were among the most discriminant postprandial plasma biomarkers distinguishing intake of breads containing whole-meal rye or rye bran from the control white wheat bread. Furthermore, subsequent metabolite profiling analysis of the consumed breads indicated that different bioprocessing/baking techniques involving exposure to microbial metabolism (e.g., sourdough fermentation) have a central role in modulating the phytochemical content of the whole-grain and bran-rich breads.

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Section: Introductionmentioning

confidence: 99%

The Postprandial Plasma Rye Fingerprint Includes Benzoxazinoid-Derived Phenylacetamide Sulfates

Hanhineva

Keski‐Rahkonen

Lappi

et al. 2014

The Journal of Nutrition

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“…BX phytochemicals are mostly reported in young plants of the monocotyledonous family Gramineae [1][2][3][4]. Their occurrence in some species of dicotyledonous families Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae was also reported [5][6][7][8][9][10][11][12]. BXs are categorized chemically into benzoxazolinones, lactams, and hydroxamic acids (Fig.…”

Section: Bxs and Derivativesmentioning

confidence: 99%

Benzoxazinoids: Cereal phytochemicals with putative therapeutic and health‐protecting properties

Adhikari

Tanwir

Gregersen

et al. 2015

Molecular Nutrition Food Res

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Benzoxazinoids (BXs) are a group of natural chemical compounds with putative pharmacological and health-protecting properties. BXs were formerly identified in and isolated from selected dicot medicinal plants and young cereal plants. Recently, BXs were found to be present in mature cereal grains and bakery products, such that knowledge about the pharmacological properties of BXs, which until now have unknowingly been consumed through the daily bread and breakfast cereals, has come into new focus. This review discusses published results from in vitro studies and a few human and animal model studies on the health effects and pharmacological responses of various BX compounds. Many of these studies have reported antimicrobial, anticancer, reproductive system stimulatory, central nervous system stimulatory, immunoregulatory, and appetite- and weight-reducing effects of BXs and/or BX derivatives. The health benefits of wholegrain intake may be associated with the solitary and/or overlapping biological effects of fibers, lignans, phenolic acids, alkylresorcinols, BXs, and other bioactive compounds. In the context of BXs as dietary ingredients, further comprehensive investigations are required to understand their biological functions, to elucidate the underlying mechanisms, to explore their potential contribution on the health effects associated with wholegrain consumption, and to examine their potential as functional food ingredients.

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“…In folk medicine of China and Taiwan, some diseases like hypertension, hepatitis, bronchitis and gastric ulcers could also be cured with Scoparia dulcis Linn. [2].…”

Section: Introductionmentioning

confidence: 99%

“…Over 50 compounds, including flavonoids, terpenoids, benzoxazinoids, etc., have been isolated from Scoparia dulcis L. around the world [2], yet there is few researches focusing on this plant in Vietnam. Therefore, studying about the chemical composition as well as the bioactivities of this medicinal herb in Vietnam is a necessity.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents From Ethyl Acetate Extract of Scoparia Dulcis Linn.

Huong

2018

JST

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This research focuses on the isolation and characterization of eight natural compounds from the ethyl acetate extract of Scoparia dulcis L. collected in An Giang province, Vietnam. Six flavonoid compounds: apigenin (1), luteolin (2), baicalein (3), oroxylin A (4), oroxylin A 7-O-β-D-glucoside (5) and vitexin (6) along with two nitrogen-containing compounds: 2,4-dihydroxy-1,4-benzoxazin-3-one (7) and uracil (8) were successfully isolated via the methods of natural product extraction. The structures of these compounds were elucidated base on 1D-NMR and 2D-NMR spectral data as well as MS and compared with those in the authentic reports. This study contributed new results to the phytochemical examination of Scoparia dulcis Linn. growing in Vietnam with the presence of the first isolated compounds as (3), (4), (5), (7) and (8).

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Benzoxazinoids from Scoparia dulcis (sweet broomweed) with antiproliferative activity against the DU-145 human prostate cancer cell line

Cited by 51 publications

References 32 publications

The Postprandial Plasma Rye Fingerprint Includes Benzoxazinoid-Derived Phenylacetamide Sulfates

The Postprandial Plasma Rye Fingerprint Includes Benzoxazinoid-Derived Phenylacetamide Sulfates

Benzoxazinoids: Cereal phytochemicals with putative therapeutic and health‐protecting properties

Chemical Constituents From Ethyl Acetate Extract of Scoparia Dulcis Linn.

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