Benzylidine pregnenolones and their oximes as potential anticancer agents: Synthesis and biological evaluation

Chalcone Scaffold in Anticancer Armamentarium: A Molecular Insight

“…Chalcone 31a has IC 50 value of 1.02 μ M and 0.79 μ M, respectively, against HCT-15 and MCF-7, while 31b has 0.81 μ M and 1 μ M, respectively. Electron withdrawing groups have an effect over the activity [ 39 ]. Chalcone-coumarin hybrid 33 ( Figure 10 ) (IC 50 = 0.53 μ M) displayed cytotoxicity against human lymphoblastic leukemia cell line (MOLT-3), where etoposide (IC 50 = 0.05 μ M) was taken as a standard.…”

Synthesis of New Phosphonoamide and Phosphonocaprolactam Derivatives via the Diethyl Chlorophosphate‐Promoted Beckmann Rearrangement of γ‐Phosphonyloximes

“…This anti [1,2]-shift allows for the prediction of the regiochemistry of this reaction and explains the obtention of a mixture of two regioisomers 3 and 3 with the major isomer 3 arising from the predominant E-stereoisomer of the starting γ -phosphonyloxime. It is important to note here that the product ratio (3:3 ) did not reflect exactly the equilibrium distribution of the starting isomers (E-2:Z-2).…”

Syntheses, characterization, antibacterial activity and molecular modelling of phenylantimony(III) heteroleptic derivatives containing substituted oximes and piperidine dithiocarbamate

“…Significant secondary bonding interactions are also frequently observed in these derivatives, as a result of M─X σ* antibonding orbital which has the potential to act as an acceptor orbital towards another donor atom . Antimony derivatives are more valuable from the medicinal chemistry point of view and in drug designing as different oximes and their metal derivatives are found to be important and exhibit significant bioactivity in chelating therapeutic drugs, as inhibitors of enzymes and as intermediates in biosynthesis of nitrogen oxides, and have antimicrobial, anticancer, fungicidal, bactericidal and antioxidant activities. In addition, dithiocarbamate derivatives with various metals have also been extensively studied because of their biological activities and use in analytical chemistry and as medicines as antidotes and antioxidants .…”