Beobachtungen �ber das Vorkommen von Anti-Leber-Serum-Antik�rpern bei Porphyria cutanea tarda des Erwachsenen

Occurrence of lymphocytotoxic antibodies of the "cold type" was studied in 92 cases with various lightdermatoses. They were detected in the sera of 39% of the patients with cutaneous porphyrias and never in cases with polymorphous light eruption and other photodermatosis. Correlations between their presence and the duration of the porphyria as well as the severity of hepatopathy could be observed. The results indicate the importance of a long-standing tissue damage in the production of these antibodies. In addition the findings confirm the hypothesis according to which polymorphous light eruption does not belong to the lupus erythematosus entity.

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Lymphocytotoxic antibodies in lightdermatoses

Horkay

Stenszky

Nagy

et al. 1977

Arch. Derm. Res.

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Autoantibodies in sporadic porphyria cutanea tarda

Malina

Lochman²,

Meyer

et al. 2003

Archives of Dermatological Research

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In an investigation of autoimmune antibodies using indirect immunofluorescence and Western blot analysis in a group of porphyria cutanea tarda patients we did not find any cytosolic antibodies potentially able to inhibit uroporphyrinogen decarboxylase. Furthermore, no known etiological factors were present in any of our patients. We therefore consider the development of the recently reported autoantibody with a molecular weight of 40 kDa a reaction to infection with the hepatitis C virus. The origin of mostly antinuclear antibodies against liver antigens (50, 45 and 56 kDa), detected in seven patients, was not identified and their etiopathogenetic implications remain unknown.

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Beobachtungen �ber das Vorkommen von Anti-Leber-Serum-Antik�rpern bei Porphyria cutanea tarda des Erwachsenen

Cited by 2 publications

References 16 publications

Lymphocytotoxic antibodies in lightdermatoses

Lymphocytotoxic antibodies in lightdermatoses

Autoantibodies in sporadic porphyria cutanea tarda

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