�ber 4-Alkylamino-bzw. 4-Arylamino-5,6-dihydro-2(1H)-pyridinthione

Synthesis of new tetrahydropyridinylidene ammonium salts and their antiprotozoal potency

“…Alternatively, a reaction of 4-isothiocyanato-4-methylpentan-2-one (4) with secondary amine 5b yielded 3b [8]. Thiones 3a-3d were transformed to the tetrahydropyridinylidene salts 6a-6d by a S-methylation/reduction procedure using deactivated Raney nickel for the selective reduction process.…”

“…The product crystallized from the reaction mixture, was sucked off, and recrystallized from ethanol or 2-propanol. 6,6-Dimethyl-4-(4-chlorophenylamino)-5,6-dihydropyridine-2(1H)-thione (3j) This compound was prepared according a reported procedure [8]. Its melting point m.p.…”

“…[9] 138°C) corresponds well with the reported one. 5,6-Dihydro-6,6-dimethyl-4-(1-pyrrolidinyl)-thiopyrane-2(1H)-thione (8) This compound was prepared according a reported procedure [14]. Its melting point m.p.…”

A novel selective synthesis of β-isothiocyanato ketones

“…Since the first representatives of 1 have been described in 1946 [1], their chemistry was extensively studied [2,3]. They were used in preparation of various pyrimidines [4][5][6], 1,3-thiazines [7,8], 1,3-oxazines [9], pyridines [10], nucleosides [11,12], pyrroles [13], 1,2,4-triazepines [14], condensed heterocycles [15][16][17], etc.…”

Reactions of resorcinol with substituted 3,4-dihydro-2(1H)-pyrimidinethiones

“…In this study, the reaction of resorcinol addition to pyrimidinethiones 1 has been examined. It is well known 3 that rearrangement products, corresponding 1,3-thiazines and aminodihydro-2(1H)-pyridinethiones, can be formed when the reaction is performed under the above conditions 1 (heating with a strong mineral acid). Thermal reactions (zinc chloride catalyst, temperature up to 140 °C) were unsuccessful (the yields were low).…”