�ber das Auftreten ?schneller Isoamylasen? im Mukoviszidosespeichel

Chilla, R; Doering, Klaus; Lubahn, H.; Arglebe, C.

doi:10.1007/bf00457478

Arch Otorhinolaryngol

1977

DOI: 10.1007/bf00457478

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�ber das Auftreten ?schneller Isoamylasen? im Mukoviszidosespeichel

R Chilla¹,

Klaus Doering²,

H. Lubahn³

et al.

Abstract: Human parotid saliva is characterized by a basic pattern of 6 isoamylases; during ageing, it contains additional isoamylases which migrate faster towards the anode. An increasing number of 'fast isoamylases' are also found in saliva from mucoviscidosis patients. Their possible symptomatological significance for the pathogenesis of mucoviscidosis which is as yet not solved is being discussed.

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1979

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Cited by 2 publications

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'Fast isoamylases' in parotid saliva of heterozygous carriers of cystic fibrosis

Chilla¹,

Arglebe²,

Lubahn³

et al. 1976

Clin Otolaryngol

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An increased number of 'fast isoamylases' is found in the parotid saliva of children with cystic fibrosis and their heterozygous parents who are clinically healthy. 'Fast isoamylases' are generated, at least in part, from the 6 isoamylases of the basic pattern by deamidation of asparagine and glutamine residues. This basic pattern is present in the parotid saliva of all subjects we have tested so far. A shift in the equilibrium between amidation and deamidation processes is discussed in terms of its possible significance for the pathogenesis of cystic fibrosis and for ageing.

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'Fast isoamylases' in parotid saliva of heterozygous carriers of cystic fibrosis

Chilla¹,

Arglebe²,

Lubahn³

et al. 1976

Clin Otolaryngol

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Premature Senescence in Cultured Skin Fibroblasts from Subjects with Cystic Fibrosis

Shapiro

Lam

Fast

1979

Science

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Cultured skin fibroblasts from subjects with cystic fibrosis exhibited normal population doubling times in early passages. After about 13 cumulative population doublings, cystic fibrosis lines doubled more slowly than controls and ceased doubling after about 19 weekly passages. Control lines continued doubling for 27 passages. The premature senescence noted in cells from subjects with cystic fibrosis reconciles controversial observations of cell doubling reported in the literature. Data presented here demonstrate that experiments with cystic fibrosis cells in late passage may generate misleading results since differences from control lines may be ascribed to generalized senile changes rather than to specific results of the cystic fibrosis genotype.

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�ber das Auftreten ?schneller Isoamylasen? im Mukoviszidosespeichel

Cited by 2 publications

References 8 publications

'Fast isoamylases' in parotid saliva of heterozygous carriers of cystic fibrosis

'Fast isoamylases' in parotid saliva of heterozygous carriers of cystic fibrosis

Premature Senescence in Cultured Skin Fibroblasts from Subjects with Cystic Fibrosis

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