�ber das Verhalten des Salicylamid im Stoffwechsel des Menschen

A, Becher; Miksch, J; Rambacher, P.; Schäfer, Annette

doi:10.1007/bf01471367

Cited by 16 publications

(4 citation statements)

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“…It is rapidly absorbed from the gastrointestinal tract after oral ingestion (4,5,6) and undergoes biotransformation primarily to its ether glucuronide and ester sulfate (7,8). A small proportion of the drug is metabolized to gentisamide glucuronide (7,9). All metabolites ( Fig.…”

Section: Introductionmentioning

confidence: 99%

“…1) are rapidly eliminated by renal excretion (7). The metabolites are stable in urine and their assay is relatively simple (7,9). These properties, plus the absence of significant binding of the free drug to plasma proteins (10), make salicylamide a convenient agent in the investigation of the effect of short-term physiologic perturbations such as artificial fever on drug metabolism.…”

Section: Introductionmentioning

confidence: 99%

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The influence of pyrogen-induced fever on salicylamide metabolism in man

Cao¹,

Gelb²,

Wolff³

1972

J. Clin. Invest.

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A B S T R A C T Salicylamide is metabolized in man by biotransformation to salicylalmide glucuronide, salicylamide sulfate, and gentisamide glucuronide. The metabolites are quantitatively and rapidly excreted in urine. Study of the metabolism of this drug in volunteers during episodes of pyrogen-induced fever shows a significant reduction in the half-life (ti) of the excretion of the drug metabolites. The proportion of the drug transformed to its major metabolite, salicylamide glucuronide, is significantly reduced by fever, with concomitant increase in the proportion of one or both of the other metabolites. Thus, the pattern of urinary metabolites of salicylamide is altered. The shortened ti of the metabolite excretion is probably due to increased hepatic and renal blood flow known to accompany pyrogen-induced fever. This concept was supported by the observation that when two subjects were placed in a high-temperature environmental chamber, a condition in which hepatic and renal blood flows are known to diminish, the ti of salicylamide metabolite excretion actually increased. No simple explanation exists to explain the changed metabolite pattern noted during febrile periods. It is most likely to be due to complex interactions between the direct or indirect effects of the pyrogens and the factors affecting the hepatic biotransformation of drugs. INTRODUCTIONDespite the widespread use of pharmacological agents such as analgesics, antipyretics, antibiotics, and antimetabolites in diseases associated with fever, little is known of the effect of fever on the disposal of drugs in man. We have studied the metabolism of salicylamide in normal volunteers before and after induction of artificial fever by administration of etiocholanolone or endotoxin (1-3). Salicylamide (o-hydroxybenzamide) is an amide

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The influence of pyrogen-induced fever on salicylamide metabolism in man

Cao¹,

Gelb²,

Wolff³

1972

J. Clin. Invest.

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show abstract

“…(2), showed that a metabolite of salicylamide from humans liberated sulfate after hydrolysis Foyc, et al ( 3 ) , also hydrolyzed the urines collected from stone-formers and found that a metabolite, supposed to be thc sulfate according to Becher's procedure, liberated both salicylairiide and sulfate in the hydrolysate. Quantitative determinations on the urines of a large number of stone-forming patients gave an average "ethereal" sulfate excretion of 31y0 of the salicylamide ingested.…”

mentioning

confidence: 97%

“…rt al. (2), showed that a metabolite of salicylamide from humans liberated sulfate after hydrolysis Foyc, et al. ( 3 ) , also hydrolyzed the urines collected from stone-formers and found that a metabolite, supposed to be thc sulfate according to Becher's procedure, liberated both salicylairiide and sulfate in the hydrolysate.…”

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confidence: 99%