�ber das Verhalten von Zink im Plasma von Ur�mikern w�hrend H�modialyse

Zazgórnik, J; Kotzaurek, R; Schmidt, Péter

doi:10.1007/bf01485431

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Since the early finding of Mansouri et al [1] and Condon and Freeman [2] of low serum zinc levels in uremic patients, many but not all [3] authors found hypozincemia in uremic patients prior to and during [4][5][6][7][8][9][10][11][12][13] maintenance hemodialysis. It has not been clarified, however, to what extent low zinc levels reflect translocation of zinc from the extracellular to the intracellular compart ment, as during acute-phase reactions [ 14], or true tissue zinc deficiency.…”

Section: Introductionmentioning

confidence: 99%

Response of Alkaline Phosphatase to Zinc Repletion in Hypozincemic Hemodialysis Patients

Stammler¹,

P²,

Bommer³

et al. 1985

Blood Purif

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The response of serum alkaline phosphatase (AP), a zinc-dependent metalloenzyme, to zinc administration via the dialysate (400 µg/l) was examined in 14 hypozincemic ( < 30th percentile of dialysis patients) hemodialysis patients and in 14 placebo-treated matched dialysis control patients. Plasma zinc and serum AP were measured three times: prior to, once weekly during (5 weeks), and 2 weeks after addition of zinc to the dialysate. The serum zinc levels remained stable in placebo-treated controls (initial 87.7 ± 12.5; final 78.6 ± 8.3 µg/dl) and increased in zinc-treated patients (initial 76.4 ± 8.3; 5th week 96.9 ± 13.3; 2 weeks after zinc withdrawal 82.3 ± 12.2 µg/dl). There was a slight increase of AP with time in placebo controls (initial 90.2 ± 26.5; 5th week 100 ± 29 U/l) and a more pronounced increase in zinc-treated patients (initial 90.8 ± 19.9; 5th week 113 ± 20.9 U/l). The difference between the two groups was marginally significant (p < 0.05; analysis of variance). It is concluded that zinc repletion via dialysate with documented increase of serum zinc levels in initially hypozincemic dialysis patients causes a reversible increase of serum AP. The result is compatible with some tissue zinc deficiency in hypozincemic dialysis patients.

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Section: Introductionmentioning

confidence: 99%

Response of Alkaline Phosphatase to Zinc Repletion in Hypozincemic Hemodialysis Patients

Stammler¹,

P²,

Bommer³

et al. 1985

Blood Purif

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Elevated plasma zinc concentrations in renal dialysis patients

Bogden¹,

Oleske²,

Weiner³

et al. 1980

The American Journal of Clinical Nutrition

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It has been suggested that hemodialysis patients might benefit from zinc supplements. However, little attention is given to the trace element content of renal dialysis fluids or to contamination of such fluids with trace metals. Pre- and postdialysis plasma copper and zinc concentrations of patients at two hospital dialysis units were measured by atomic absorption spectrophotometry. The plasma zinc concentration increased substantially in 34 of 37 patients as a result of dialysis. Measurement of dialysate zinc concentrations after primary source of zinc. Because of the possibility of zinc toxicity, zinc nutritional status should be carefully evaluated before recommending zinc supplementation for dialysis patients. Uremic patients dialyzed with certain disposable Cuprophan-membrane coils receive substantial quantities of zinc during dialysis; other Cuprophan-membrane coils tested released negligible quantities of zinc.

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Acute Zinc Toxicity in Haemodialysis

Gallery¹,

Blomfield²,

Dixon³

1972

BMJ

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New Zealand) used water stored in a galvanized tank. She subsequently was found to have severe anaemia with raised plasma and erythrocyte zinc concentrations. Intercurrent hospital haemodialyses and subsequent home dialyses with deionized water were symptom-free.Experimental haemodialyses of dogs against small concentrations of zinc showed a disproportionate rise in plasma zinc and possible uptake of zinc by the liver.

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�ber das Verhalten von Zink im Plasma von Ur�mikern w�hrend H�modialyse

Cited by 4 publications

References 3 publications

Response of Alkaline Phosphatase to Zinc Repletion in Hypozincemic Hemodialysis Patients

Response of Alkaline Phosphatase to Zinc Repletion in Hypozincemic Hemodialysis Patients

Elevated plasma zinc concentrations in renal dialysis patients

Acute Zinc Toxicity in Haemodialysis

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