�ber den Einflu� der chronisch intermittierenden H�modialyse auf den cellul�ren Immunmangel bei terminaler Niereninsuffizienz

He, Reis; Vh, Heimsoth; Hirche, Hans-Jürgen; Eitelhuber, U

doi:10.1007/bf01468585

Cited by 9 publications

(2 citation statements)

References 13 publications

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“…Another possible feature contributing to the immunodeficiency of uremia is the presence of nondialyzable or partly dialyzable [33] serum factors. Several recent reports, for example, using both leukotaxic response and lymphocyte transformation, implicate circulating guanidines, such as guanidinosuccinic acid and methylguanidine, in the defective immunity of uremia [8,19,26,27,35].…”

Section: Immunoglobulinsmentioning

confidence: 99%

Immune System in Uremia

Dobbelstein¹

1976

Nephron

127

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Section: Immunoglobulinsmentioning

confidence: 99%

Immune System in Uremia

Dobbelstein¹

1976

Nephron

127

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“…"Ετερον σημεϊον ά^ιον σχολιασμού, είναι ότι δέν διεπιστώθη εις τήν παρούσαν ερευναν διαφορά είς τήν βλαστογένεσιν με ταξύ αιμοκαθαιρομένων ή υφισταμένων περιτοναϊκήν κάθαρσιν ου ραιμικών καί συντηρητικώς θεραπευομένων τοιούτων, ώς έτεροι αναφέρουν 125 . 'Εν τούτοις δέν είναι δυνατόν νά έΕαχθοϋν άσφα-λή συμπεράσματα, δεδομένου ότι εκ των 11 ασθενών της ομάδος αυτής, μόνον 4 εορίσκοντο είς πρόγραμμα αΐ,μοδιαλύσεως , διά δέ την περιτοναϊκή ν κάθαρσιν ισχύουν αί ϊδιαι επιφυλάξεις αϊ ο πό ία ι, διετυπώθησαν προηγουμένως.…”

Section: β βλαστικος μετασχηματισμος λεμφοκυτταρωνunclassified

Ο Σχηματισμος Μη Ανοσων Ροδακων Και Ο Βλαστικος Μετασχηματισμος Των Λεμφοκυτταρων Επι Χρονιας Ουραιμιας

Κουρουμαλησ¹

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Spontane Lymphocytentransformation bei chronischer Niereninsuffizienz

1975

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3H-thymidine uptake of lymphocytes cultured from patients with regular dialysis treatment was determined at the time of maximal transformation, which was ascertained in previous investigations to be 5 days after the beginning of incubation. Spontaneous DNS synthesis was found to be significantly depressed: 1137 plus or minus 1122 c.p.m./culture; controls: 9783 plus or minus 7499 c.p.m./culture, whereas LDH activity in the supernatant culture medium measured as a parameter of continuous cell destruction showed no alteration. After stimulation with 400 mug PHA DNS synthesis in 7 patients was also decreased, but elevated in 5 patients with previous infections. After incubation with added serum from 11 chronic uremic patients, spontaneous lymphocyte transformation in cultures sampled from 2 healthy subjects was also found to be depressed with positive correlation to the hemoglobin and hematocrit levels in the corresponding blood. The significantly increased LDH activity values in the medium as the consequence of impaired cll viability showed also positive correlation with 3-H-thymidine uptake levels; therefore depressed DNS synthesis cannot be due alone to accelerated cell destruction. In analogy to the erythrocytes, two stimultaneous effects of uremic toxins in serum are assumed to be exerted on the lymphocytes: metabolic inhibition of DNS synthesis and impaired cell viability.

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�ber den Einflu� der chronisch intermittierenden H�modialyse auf den cellul�ren Immunmangel bei terminaler Niereninsuffizienz

Cited by 9 publications

References 13 publications

Immune System in Uremia

Immune System in Uremia

Ο Σχηματισμος Μη Ανοσων Ροδακων Και Ο Βλαστικος Μετασχηματισμος Των Λεμφοκυτταρων Επι Χρονιας Ουραιμιας

Spontane Lymphocytentransformation bei chronischer Niereninsuffizienz

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