�ber den Einflu� von Wasserstoffionenkonzentration und CO2-Druck im Liquor cerebrospinalis auf die Atmung

Loeschcke, H. H.; Koepchen, H. P.; Gertz, K. H.

doi:10.1007/bf00363036

Cited by 126 publications

(16 citation statements)

References 19 publications

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“…This highly vascularized region at the level of the obex in the floor of the fourth ventricle is rich in parenchymal cells, and receives fine non-myelinated fibers and thicker fibers from adjacent bulbar regions. 24) In decerebrate, curarized, vagotomized cats, spots could be found just lateral to the area postrema and above or below the nucleus hypoglossi, medial to the nucleus fasciculi solitari, which show increased electrical activity (spiking) after intra-carotidal or intravenous injection of a small amount of hypertonic saline solu tion.25) Whether the area postrema also represents a sensitive zone to pH and pC02 variations48, 89,90,93) cannot be decided at present. However, it seems important to note that a possible intramedullary chemosensitive zone lies within the terminal area of afferent vagal fibers.…”

Section: The Region Of the Obey (Area Postrema)mentioning

confidence: 99%

Afferent Fibers of Cardiovascular and Pulmonary Origins and Their Intrabulbar Connections (A Review)

Oberholzer

1963

Tohoku J. Exp. Med.

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Section: The Region Of the Obey (Area Postrema)mentioning

confidence: 99%

Afferent Fibers of Cardiovascular and Pulmonary Origins and Their Intrabulbar Connections (A Review)

Oberholzer

1963

Tohoku J. Exp. Med.

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“…It is known that perfusion of the fourth ventricle with solutions of acidic pH causes an increase in respiratory volume (Loeschcke, Koepchen & Gertz, 1958). The hydrochloride of procaine used in the present experiments lowers the pH of the artificial cerebrospinal fluid in which it is dissolved.…”

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confidence: 83%

“…They observed an initial increase in the amplitude of respiration and a rise of blood pressure, both of which were later depressed. In the present experiments the effect of procaine perfused into the cerebral ventricles of conscious dogs was studied and an attempt was made to determine its site of action.It is known that perfusion of the fourth ventricle with solutions of acidic pH causes an increase in respiratory volume (Loeschcke, Koepchen & Gertz, 1958 …”

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confidence: 99%

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Procaine perfused into cerebral ventricles and subarachnoid space in conscious and anaesthetized dogs

Haranath

Venkatakrishna‐Bhatt

1968

British J Pharmacology

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A.P. Inidia 1. Perfusion of 1% procaine into the cerebral ventricles of conscious dogs produced mild paresis, defaecation, vomiting, jerky movements of eyelids, brisk nystagmus, increase in amplitude of respiration and sometimes loss of consciousness. Procaine 2% produced paralysis, loss of consciousness and sometimes respiratory depression. 2. Procaine 20/, perfused into the cerebral ventricles of dogs under chloralose anaesthesia produced an initial increase in amplitude of respiration, which preceded its final depression, which is due primarily to procaine and only partly to a change in pH. 3. The site of action for the initial increase in amplitude of respiration was in the fourth ventricle, for it did not occur on perfusion of procaine into the cranial subarachnoid space. 4. Perfusion of spinal subarachnoid space with procaine is enough to cause respiratory failure even when the procaine does not reach the medulla.Haranath, Naseem Ayesha Begum & Sitaramayya (1965) described the effects of procaine injected into the cerebral ventricles of conscious dogs and its effects on perfusion into the cerebral ventricles of dogs under chloralose anaesthesia. They observed an initial increase in the amplitude of respiration and a rise of blood pressure, both of which were later depressed. In the present experiments the effect of procaine perfused into the cerebral ventricles of conscious dogs was studied and an attempt was made to determine its site of action.It is known that perfusion of the fourth ventricle with solutions of acidic pH causes an increase in respiratory volume (Loeschcke, Koepchen & Gertz, 1958

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“…There is, however, another explanation. Loeschcke and his co-workers (Loeschcke, Koepchen & Gertz, 1958;Loeschcke & Koepchen, 1958a, b) have recently made the interesting observation that solutions of different pH, or solutions containing procaine, veratridine or lobeline, produced no respiratory changes when applied to the floor of the fourth ventricle but did so when the fourth ventricle was perfused, and these solutions passed through the lateral recesses into the adjacent subarachnoidal space of the base of the brain. Injections of these solutions into the lateral recesses were also effective.…”

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Experiments on the site of action of tubocurarine when applied via the cerebral ventricles

Feldberg¹,

Malcolm²

1959

The Journal of Physiology

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In the present experiments an attempt was made to locate the site where tubocurarine acts to produce the convulsive effects and the accompanying changes in electrical activity of the brain on injection into the lateral cerebral ventricle. Two different approaches were made. By recording the electrical activity from two points on either side of the mid line, it could be demonstrated that the activity produced by the unilateral injection occurred with similar latencies on both sides. This excludes structures lining the lateral ventricles as the sites at which the activity originated. In the course of these experiments it was found that records obtained from the cellular layer of Ammon's horn during the action of tubocurarine showed a characteristic pattern different from the patterns found in any other region so far examined.In the second approach the tubocurarine was perfused through a cannula ending in the lateral ventricle and the effluent was collected from various points between the third ventricle and the cisterna. In these experiments the muscular effects were recorded on a myograph and changes in excitability tested by the response of the quadriceps muscle to tapping its tendon. METHODSThe experiments were performed on cats under chloralose anaesthesia (60 mg/kg intravenously).In experiments in which records were taken of the electrical activity of the brain and in which evoked responses to peripheral nerve stimulation (peroneal nerve) were recorded before and after an intraventricular injection of tubocurarine, the methods used were those previously described (Feldberg, Malcolm & Smith, 1957), and tubocurarine was injected intravenously. In those experiments in which tubocurarine was perfused through a cannula in the lateral ventricle and the effluent was collected from the cisterna or the aqueduct, the methods were essentially those described by Feldberg & Bhattacharya (1958), but the perfusion fluid used was not always Locke's solution but often an 'artificial cerebrospinal fluid' introduced by Merlis (1940) and later used by Leusen (1949). Its composition was as follows (g/l.): NaCl 8-10, KCI 0-25, CaCI2 014, MgCl2 0-11, NaHCO3 1-76, NaH2PO4 0 07, (NH2)2CO 0-13, glucose 0*61. No difference was observed in the effects of tubocurarine when Locke's solution or artificial c.s.f. was used for perfusion. The rate of * Present address: Department of Physiology, Marischal College, Aberdeen.

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�ber den Einflu� von Wasserstoffionenkonzentration und CO2-Druck im Liquor cerebrospinalis auf die Atmung

Cited by 126 publications

References 19 publications

Afferent Fibers of Cardiovascular and Pulmonary Origins and Their Intrabulbar Connections (A Review)

Afferent Fibers of Cardiovascular and Pulmonary Origins and Their Intrabulbar Connections (A Review)

Procaine perfused into cerebral ventricles and subarachnoid space in conscious and anaesthetized dogs

Experiments on the site of action of tubocurarine when applied via the cerebral ventricles

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