�ber den Stoffwechsel des menschlichen Herzens

Keul, J.; Doll, E; Steim, H; Homburger, H; Kern, Horst F.; Reindell, H

doi:10.1007/bf00363205

Cited by 60 publications

(3 citation statements)

References 52 publications

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“…The contribution of glucose and fatty acids fell to 16% and 21%, respectively. In contrast, lactate oxidation accounted for 62% of the total amount of oxygen consumed by the heart [8,9]. The findings in human volunteers were supported by results obtained in awake dogs [10].…”

Section: Introductionsupporting

confidence: 65%

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Interrelationship between lactate and cardiac fatty acid metabolism

Vusse¹,

Groot

1992

Mol Cell Biochem

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This overview is presented, in the main, to summarize the following aspects of lactate and cardiac fatty acid metabolism: 1. The utilization of exogenous carbohydrates and fatty acids by the heart. 2. The competition between lactate and fatty acids in cardiac energy metabolism. 3. The effect of lactate on endogenous triacylglycerol homeostasis. 4. Lactate-induced impairment of functional recovery of the post-ischemic heart. 5. The effect of lactate on lipid metabolism in the ischemic and post-ischemic heart. 6. The consequences of hyperlactaemia for cardiac imaging.

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Section: Introductionsupporting

confidence: 65%

“…Keul and colleagues [8,9] found that in the human heart at rest the contribution of fatty acids to oxidative metabolism was 34% and that the remaining part of energy required was obtained from carbohydrates. Oxidation of glucose and lactate accounted for 31% and 29% of total oxygen consumption, respectively.…”

Section: Introductionmentioning

confidence: 98%

Interrelationship between lactate and cardiac fatty acid metabolism

Vusse¹,

Groot

1992

Mol Cell Biochem

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“…In addition to the brain, lactate has also been reported as preferred fuel under stress/strain conditions in heart and skeletal muscle, and perhaps lactate also serves as a signaling molecule in such conditions (reviewed in Ref ). Already moderate physical activity doubled the contribution of lactate for total cardiac energy production in healthy subjects , while heavy exercise (at 200 W) increased lactate uptake by a factor of four, with a 60% contribution to cardiac energy production . Studies on rats demonstrated that increased blood lactate levels can have positive effects on heart function during a septic or hemorrhagic shock .…”

mentioning

confidence: 99%

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1

et al. 2019

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Carbonic anhydrases (CA) catalyze the reversible hydration of CO 2 to protons and bicarbonate and thereby play a fundamental role in the epithelial acid/base transport mechanisms serving fluid secretion and absorption for whole‐body acid/base regulation. The three carbonic anhydrase‐related proteins (CARPs) VIII, X, and XI, however, are catalytically inactive. Previous work has shown that some CA isoforms noncatalytically enhance lactate transport through various monocarboxylate transporters (MCT). Therefore, we examined whether the catalytically inactive CARPs play a role in lactate transport. Here, we report that CARP VIII, X, and XI enhance transport activity of the MCT MCT1 when coexpressed in Xenopus oocytes, as evidenced by the rate of rise in intracellular H+ concentration detected using ion‐sensitive microelectrodes. Based on previous studies, we suggest that CARPs may function as a ‘proton antenna’ for MCT1, to drive proton‐coupled lactate transport across the cell membrane.

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Positron Emission Tomography of the Heart: Methodology, Findings in the Normal and the Diseased Heart, and Clinical Applications

Schelbert¹

2004

Pet

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�ber den Stoffwechsel des menschlichen Herzens

Cited by 60 publications

References 52 publications

Interrelationship between lactate and cardiac fatty acid metabolism

Interrelationship between lactate and cardiac fatty acid metabolism

Catalytically inactive carbonic anhydrase‐related proteins enhance transport of lactate by MCT1

Positron Emission Tomography of the Heart: Methodology, Findings in the Normal and the Diseased Heart, and Clinical Applications

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