�ber die Aldosteronausscheidung bei Schwangerschaften und bei Schwangerschaftstoxikosen

Secretion Rate of Aldosterone in Normal Pregnancy*

“…At the same time, Martin and Mills (20) reported similar findings based on a physicochemical determination of aldosterone. Since then, several groups of investigators (21)(22)(23)(24)(25) have confirmed the earlier findings of an increased urinary excretion of acid-hvdirolyzable conjugate of aldosterone in pregnancy.…”

“…High urinary values of aldosterone have been reported in the last trimester of normal pregnancy by many investigators (19)(20)(21)(22)(23)(24)(25). High urinary excretion of aldosterone was assumed to reflect an increased secretion of aldosterone by the adrenal gland, but the findings of Jones and associates (9) suggested that this high urinary excretion may not reflect a proportionate increased secretion of the hormone.…”

The Aldosterone Blocking Effects of Spirolactones

“…Recent evident indicates that aldosterone is not an important etiologic factor in toxemia in pregnancy. Although the output of aldosterone in such patients was higher than in the nonpregnant subject it was usually lower than in pregnant women who had no signs of toxemia (61,65,66). It is not surprising therefore that SC 8109 did not produce a diuresis in the toxic patient (64).…”

“…The syndrome of hype raldosteronism, due either to adrenal tumor or adrenal hyperplasia was first described by Conn and Louis (58). The hypo kalemia and alkalosis of primary aldosteronism are readily reversed by the spirolactones (59)(60)(61). The doses of Aldactone required to produce significant effects in such patients are usually much greater than the doses acquired to achieve diuresis in patients with edema.…”

Sodium Metabolism in Normal Pregnancy and Pre-Eclampsia

“…(Koczorek, Wolff and Beer, 1957;Rinsler and Rig by, 1957;Kumar, Fellbam and Gornall, 1959). The decrease in exchangeable sodium in pre-eclampsia might thus be the result of changes in the secretion of aldosterone.…”