�ber Lage- und Formver�nderungen des Hypothalamus und des Infundibulum in Phylogenese und Ontogense

Diepen, R.

doi:10.1007/bf00213242

Cited by 29 publications

(2 citation statements)

References 13 publications

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“…Limited cytoarchitectonic studies of the developing human brain have been carried out but they were not concerned with the dynamics of fetal nuclear differentiation. Human fetal material has at times been considered cursorily in studies focusing either on the adult brain and early embryonic brain material-where cell groups are not yet formed (Gilbert, 1935;Diepen, 1948;Kühlenbeck, 1954;Diepen, 1962). More recent chemoarchitectonic studies of the human fetal hypothalamus reported on the development of the hypophyseal portal plasma system (Trandafir et al, 1982), CRH containing circuitry (Bugnon et al, 1982), growth hormone releasing hormone (GRH) neurons (Bloch et al, 1984), somatostatin (Ackland et al, 1983), oxytocin and vasopressin (Burford and Robinson, 1982), neurophysin (Mai et al, 1997).…”

Section: Introductionmentioning

confidence: 97%

Hypothalamus of the human fetus

Koutcherov

Kurths

Paxinos

2003

Journal of Chemical Neuroanatomy

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Section: Introductionmentioning

confidence: 97%

Hypothalamus of the human fetus

Koutcherov

Kurths

Paxinos

2003

Journal of Chemical Neuroanatomy

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“…Limited cytoarchitectonic studies of the developing human brain have been carried out, but they were not concerned with the dynamics of fetal nuclear differentiation. Human fetal material has at times been considered cursorily in studies focusing either on the adult brain or on early embryonic brain material, in which cell groups are not yet formed (Gilbert, 1935;Diepen, 1948Diepen, , 1962Kü hlenbek, 1954;Kahle, 1956;Richter, 1965). Papers on more recent chemoarchitectonic studies of the human fetal hypothalamus have reported on the development of the hypophyseal portal plasma system (Trandafir et al, 1982), CRH-containing circuitry (Bugnon et al, 1982), growth hormone-releasing hormone (GRH) neurons (Bloch et al, 1984), somatostatin (Ackland et al, 1983), oxytocin and vasopressin (Burford and Robinson, 1982) and neurophysin (Mai et al, 1997).…”

mentioning

confidence: 99%

Organization of human hypothalamus in fetal development

Koutcherov

Kurths

Ashwell

et al. 2002

J of Comparative Neurology

112

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The organization of the human hypothalamus was studied in 33 brains aged from 9 weeks of gestation (w.g.) to newborn, using immunohistochemistry for parvalbumin, calbindin, calretinin, neuropeptide Y, neurophysin, growth-associated protein (GAP)-43, synaptophysin, and the glycoconjugate 3-fucosyl- N-acetyl-lactosamine. Developmental stages are described in relation to obstetric trimesters. The first trimester (morphogenetic periods 9-10 w.g. and 11-14 w.g.) is characterized by differentiating structures of the lateral hypothalamic zone, which give rise to the lateral hypothalamus (LH) and posterior hypothalamus. The PeF differentiates at 18 w.g. from LH neurons, which remain anchored in the perifornical position, whereas most of the LH cells are displaced laterally. A transient supramamillary nucleus was apparent at 14 w.g. but not after 16 w.g. As the ventromedial nucleus differentiated at 13-16 w.g., three principal parts, the ventrolateral part, the dorsomedial part, and the shell, were revealed by distribution of calbindin, calretinin, and GAP43 immunoreactivity. The second trimester (morphogenetic periods 15-17 w.g., 18-23 w.g., and 24-33 w.g.) is characterized by differentiation of the hypothalamic core, in which calbindin- positive neurons revealed the medial preoptic nucleus at 16 w.g. abutted laterally by the intermediate nucleus. The dorsomedial nucleus was clearly defined at 10 w.g. and consisted of compact and diffuse parts, an organization that was lost after 15 w.g. Differentiation of the medial mamillary body into lateral and medial was seen at 13-16 w.g. Late second trimester was marked by differentiation of periventricular zone structures, including suprachiasmatic, arcuate, and paraventricular nuclei. The subnuclear differentiation of these nuclei extends into the third trimester. The use of chemoarchitecture in the human fetus permitted the identification of interspecies nuclei homologies, which otherwise remain concealed in the cytoarchitecture.

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Ventricular system of the brain of the dolphin, Tursiops truncatus, with comparative anatomical observations and relations to brain specializations

McFarland

Morgane

Jacobs

1969

J of Comparative Neurology

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A comparative and quantitative anatomical study of the cerebral ventricular system of the dolphin, Tursiops truncatus, and six other mammalian species, including man, has been made in the course of extensive neuroanatomical investigations of the dolphin. Several techniques have been used in these studies to confirm the morphological arrangement and contours of the ventricles. Casts of the ventricles were produced by use of a variety of casting media and methods and their relative merits were investigated and described. Following injection of the brain with casting media, the brain was either totally removed by dissection or digestion or one hemisphere dissected away to reveal the relationships of the ventricular cast to the opposite cerebral hemisphere. Serial sections of the brains of three dolphins were cut in three cardinal planes, and from these a model of the entire ventricular system was reconstructed. Serial sections (Nissl and Loyez) were also used to identify structures closely related to the ventricular cavities. Our results show that components of the cerebral ventricular system of the dolphin reflect, to a considerable degree, many of the specialized features of that brain including brachycephaly, widened and foreshortened temporal lobes, large limbic lobe, hypodeveloped frontal region, absence of a n occipital pole, and massive development of the tectal acoustic apparatus. The morphological characteristics of the ventricular system and the relationship of this system to brain areas is discussed with respect to possible functional and phylogenetic implications.The ventricles of the brain have interested investigators from at least the time of Leonard0 da Vinci, who made the first known ventricular cast (McMurrich, '30). Historical accounts of various aspects of subsequent research on the cerebral ventricular system have been reviewed by Millen and Woollam ('62), Clarke ('62), and Adelmann ('66). The cerebral ventricles are of particular interest for the reason that they are primordial hollows of the brain (as distinct from secondary hollows such as the subarachnoid space, subdural space, cavum septi pellucidi, etc.) and reflect in changes of their configurations and size the development and growth of the neural tube. 1 Present address: New York Aquarium, New York, New York. 1This research was supported by grant NB 03097, National Institute of Neurological Diseases and Blindness, National Institutes of Health, and grants GB 4407 and 5230, National Science Foundation.2The cavum septi pellucidi, as reviewed in detail by Thompson ('32), is a space bounded dorsally by the corpus callosum, posteriorly and ventrally by the fornix, and laterally by the stretched laminae of the septi pellucidi. This space has been called the "fifth" ventricle by Forbes (1882), Elliot Smifh (1896, '00-'03), and later workers. In the dolphin, the cavum septi pellucidi is open anteriorly as it is in the dog, cat and monkey. The "sixth" ventricle or cavum Vergae was reviewed by Dand ('31) as a space bounded laterally bp th...

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�ber Lage- und Formver�nderungen des Hypothalamus und des Infundibulum in Phylogenese und Ontogense

Cited by 29 publications

References 13 publications

Hypothalamus of the human fetus

Hypothalamus of the human fetus

Organization of human hypothalamus in fetal development

Ventricular system of the brain of the dolphin, Tursiops truncatus, with comparative anatomical observations and relations to brain specializations

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