2024
DOI: 10.1111/jcmm.18407
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Berberine ameliorates chronic intermittent hypoxia‐induced cardiac remodelling by preserving mitochondrial function, role of SIRT6 signalling

Zijun Zhou,
Qiusheng Zhao,
Yuting Huang
et al.

Abstract: Chronic intermittent hypoxia (CIH) is associated with an increased risk of cardiovascular diseases. Previously, we have shown that berberine (BBR) is a potential cardioprotective agent. However, its effect and mechanism on CIH‐induced cardiomyopathy remain uncovered. This study was designed to determine the effects of BBR against CIH‐induced cardiac damage and to explore the molecular mechanisms. Mice were exposed to 5 weeks of CIH with or without the treatment of BBR and adeno‐associated virus 9 (AAV9) carryi… Show more

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