Berberine and barberry (<scp><i>Berberis vulgaris</i></scp>): A clinical review

Imenshahidi, Mohsen; Hosseinzadeh, Hossein

doi:10.1002/ptr.6252

Cited by 254 publications

(147 citation statements)

References 131 publications

(176 reference statements)

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“…Although various studies about berberine and stachyose have been published (Imenshahidi & Hosseinzadeh, ; Li et al, ), to the best of our knowledge, this is the first report about their combined effects on glucose metabolism. As is well known, the concentrations and ratios of components used in combined treatment greatly influence the effects.…”

Section: Resultsmentioning

confidence: 77%

“…Currently, berberine is primarily obtained by chemical synthesis and is used in China in the treatment of diarrhea for its effects on intestines and its antibacterial effects (Imenshahidi & Hosseinzadeh, ; More, Kharat, & Kharat, ). Although berberine is also used in obese diabetic patients, its poor intestinal absorption may induce different degrees of diarrhea in some patients (Imenshahidi & Hosseinzadeh, ) and therefore prevents long‐term and wide application in the treatment of Type 2 diabetes mellitus (T2DM). Moreover, studies revealed that berberine exerts antidiabetic effects by modulating gut microbiota (Han, Lin, & Huang, ).…”

Section: Introductionmentioning

confidence: 99%

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Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Wang

Lei

et al. 2019

Phytotherapy Research

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Berberine (BBR), a small alkaloid, is used as a hypoglycemic agent in China. Stachyose (Sta), a Rehmannia glutinosa oligosaccharide, acts as a prebiotic. This study aimed to evaluate whether BBR combined with Sta produced better glycometabolism than BBR alone, and explored the effects on gut microbiota and metabolomics. Type-2 diabetic db/db mice were administered BBR (100 mg/kg), Sta (200 mg/kg), or both by gavage once daily. Glucose metabolism, the balance of αand β-cells, and mucin-2 expression were ameliorated by combined treatment of BBR and Sta, with stronger effects than upon treatment with BBR alone. The microbial diversity and richness were altered after combined treatment and after treatment with BBR alone. The abundance of Akkermansia muciniphila was increased by combined treatment compared to treatment with BBR alone, while the levels of the metabolite all-transheptaprenyl diphosphate were decreased and the levels of fumaric acid were increased, which both showed a strong correlation with A. muciniphila. In summary, BBR combined with Sta produced better glycometabolism than BBR alone through modulating gut microbiota and fecal metabolomics, and may aid in the development of a novel pharmaceutical strategy for treating Type 2 diabetes mellitus. K E Y W O R D Sberberine, metabolomics, microbiota, stachyose, type 2 diabetes

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Section: Resultsmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Wang

Lei

et al. 2019

Phytotherapy Research

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show abstract

“…Berberine (BBR) is an isoquinoline alkaloid, source of berberis, and has been widely used in traditional Chinese medicine for hundreds of years. Modern pharmacology demonstrates that BBR has antibacterial, anti-diabetic, antihyperlipidemic, and multiple cardioprotective effects (Imenshahidi and Hosseinzadeh, 2019). Many studies showed that BBR could regulate metabolism disorder, increase insulin sensitivity, and improve glycometabolism, which may indicate it has potential in the treatment of NAFLD (Zhu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model

et al. 2020

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significantly enriched with DEGs. The expression levels of the crucial genes from the functional analysis were also confirmed by quantitative PCR (qPCR). Conclusion: BBR can significantly improve hepatic steatosis in HCD-fed zebrafish larvae. Its mechanisms might be associated with the regulation of lipid metabolism, oxidative stress, and iron homeostasis. Raman imaging in larval zebrafish might become a useful tool for drug evaluation. Mainly, the gene expression profiles provide molecular information for BBR on the prevention and treatment of pediatric NAFLD.

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“…This evidence suggests that BBR is a potential drug for the treatment of T2DM. However, BBR may result in gastrointestinal reactions (including diarrhea and constipation) in some patients due to its poor absorption, thereby limiting its long-term and wide application in T2DM management [3,5] .…”

Section: Introductionmentioning

confidence: 99%

Stachyose improves the anti-diabetic effects of berberine by regulating intestinal microbiota and SCFAs in spontaneous type 2 diabetic KKAy mice

Cao

Lei

et al. 2020

Preprint

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Background: Berberine (BBR) has the beneficial effects of anti-inflammation, anti-bacteria, and anti-diabetes. The clinical application of BBR has been hindered by its poor gastrointestinal absorption. Stachyose (Sta), a prebiotic agent, improves the composition of gut microbiota and benefits for diabetes. We therefore investigated whether Sta improves the anti-diabetic actions of BBR using type 2 diabetic KKAy mice.Methods: KKAy mice were randomly divided into four groups: Con, Sta (200 mg/kg), BBR (100 mg/kg), and BBR+Sta (BBR: 100 mg/kg, Sta: 200 mg/kg). Mice were administered intragastrically once daily for 8 weeks. The mice weight, glycemia, glycated hemoglobin, and levels of insulin, glucagon, and inflammatory cytokines were monitored. Oral glucose tolerance tests and insulin tolerance tests were performed; protein and gene expression levels were detected by Western blot and qRT-PCR, respectively; gut microbiota and short-chain fatty acids (SCFAs) in feces were analyzed.Results: The combination of BBR and Sta is more effective than BBR alone in blood glucose control, improvement of insulin resistance and islet functions, inflammatory mediators decrease, and maintenance of intestinal barrier integrity. Gut microbiota analysis demonstrates that both BBR and combination treatments enhance the abundance of Bacteroidaceae and Akkermansiaceae and decrease Lachnospiraceae levels, whereas Akkermansiaceae elevation due to the administration of BBR with Sta is more significant than BBR alone. Interestingly, the proportion of Lactobacillaceae increases with combination treatment, but is diminished by BBR treatment. Additionally, BBR with Sta significantly reduces the concentrations of fecal SCFAs compared to BBR.Conclusions: The combination of BBR and Sta imparts better effects on the maintenance of glycemia and intestinal homeostasis than BBR alone by modulating gut microbiota and SCFAs, thereby providing a novel approach for the treatment of type 2 diabetes mellitus.

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Berberine and barberry (Berberis vulgaris): A clinical review

Cited by 254 publications

References 131 publications

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Berberine combined with stachyose induces better glycometabolism than berberine alone through modulating gut microbiota and fecal metabolomics in diabetic mice

Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model

Stachyose improves the anti-diabetic effects of berberine by regulating intestinal microbiota and SCFAs in spontaneous type 2 diabetic KKAy mice

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