Berberine attenuates non-alcoholic steatohepatitis by regulating chemerin/CMKLR1 signalling pathway and Treg/Th17 ratio

Lu, Zengsheng; Lu, Feng‐Bin; Wu, Liyan; He, Beihui; Chen, Zhiyun; Yan, Maoxiang

doi:10.1007/s00210-020-01914-1

Cited by 15 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 37 BBR also ameliorates non-alcoholic steatohepatitis, which is associated with the restoration of the Treg/Th17 ratio. 38 In this study, we examined the effect of BBR on Treg/Th17 cells in sepsis. Additionally, by blocking CD25 with a CD25 antibody, we confirmed the involvement of Treg cells in BBR activity, as lung injury worsened when CD25 was neutralized.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling

Chen¹,

Liu²,

Wang³

et al. 2023

DDDT

View full text Add to dashboard Cite

Purpose A common complication of sepsis is acute lung injury (ALI), which is associated with an acute onset, rapid disease changes, and high mortality. Regulatory T (Treg) and T helper 17 (Th17) cells comprise CD4 + T cell subsets, which strongly influence inflammation during ALI. In this study, we investigated the effect of berberine (BBR), an antioxidant, anti-inflammatory, and immunomodulatory drug, on the inflammatory response and immune state in mice with sepsis. Methods A mouse model of cecal ligation and puncture (CLP) was established. The mice were intragastrically administered 50 mg/kg BBR. We used histological techniques to evaluate inflammatory tissue injury and flow cytometry for analyzing Treg/Th17 levels. We also assessed NF-κB signaling pathways by Western blotting assays and immunofluorescence staining. Enzyme-linked immunosorbent assay (ELISA) was performed to measure the content of cytokines. Results Treatment with BBR considerably mitigated lung injury while improving survival, post-cecal ligation, and puncture (CLP). Treatment with BBR ameliorated pulmonary edema and hypoxemia in septic mice and inhibited the NF-κB signaling pathway. BBR also increased Treg cells and decreased Th17 proportions in the spleen and lung tissue of CLP-treated mice. Blocking Treg cells weakened the protective effect of BBR on sepsis-associated lung injury. Conclusion Overall, these results suggested that BBR is a potential therapeutic agent for sepsis.

show abstract

Section: Discussionmentioning

confidence: 99%

“…37 BBR also ameliorates nonalcoholic steatohepatitis, which is associated with the restoration of the Treg/Th17 ratio. 38 In this study, we examined the Traditional Chinese medicine (TCM) is extensively used to treat inflammatory diseases. Many studies have suggested the importance of TCM for modulating the Th17/Treg balance.…”

mentioning

confidence: 99%

Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling

Chen¹,

Liu²,

Wang³

et al. 2023

DDDT

View full text Add to dashboard Cite

show abstract

“…Furthermore, key adipogenic proteins SREBP1, ACC, FASN and SCD-1 mRNA as well as inflammatory factors TNF-α and IL-6 mRNA expression in the liver of NASH mice were simultaneously detected to be reduced (Shu et al, 2021). Lu et al found that BBR treatment significantly reduced the expression of hepatic chemokines CMKLR1 and CCR2 proteins associated with inflammation and restored the intrahepatic Treg/Th17 ratio as a way to control inflammation development during NAFLD and reduce liver injury (Lu et al, 2021). Ma et al discovered that BBR could also inhibit NLRP3 inflammasome and caspase-1 expression through the ROS/TXNIP axis in a mouse model to control inflammation development (Mai et al, 2020).…”

Section: Therapeutic Effects Of Alkaloid Components On Nafldmentioning

confidence: 99%

Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Cao

Fang

Sun

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is a common condition that is prevalent in patients who consume little or no alcohol, and is characterized by excessive fat accumulation in the liver. The disease is becoming increasingly common with the rapid economic development of countries. Long‐term accumulation of excess fat can lead to NAFLD, which represents a global health problem with no effective therapeutic approach. NAFLD is a complex, multifaceted pathological process that has been the subject of extensive research over the past few decades. Herbal medicines have gained attention as potential therapeutic agents to prevent and treat NAFLD due to their high efficacy and low risk of side effects. Our overview is based on a PubMed and Web of Science database search as of Dec 22 with the keywords: NAFLD/NASH Natural products and NAFLD/NASH Herbal extract. In this review, we evaluate the use of herbal medicines in the treatment of NAFLD. These natural resources have the potential to inform innovative drug research and the development of treatments for NAFLD in the future.

show abstract

“…Another study reported that the HFD remarkably increased the expression of Pro-inflammatory adipokine such as chemerin, chemerin-like receptor 1 (CMKLR1) and Pro-inflammatory C-C chemokine receptor 2 (CCR2) to regulate the intrahepatic ratio of Treg/Th17 cells in rats. Meanwhile, berberine (BBR), the main component of the Chinese medicine Coptis chinensis, obviously improved free fatty acid (FFA) accumulation, lipid deposition, and steatohepatitis in rats by repairing the balance of Treg/Th17 ratio and downregulating the chemerin/CMKLR1 pathway [111]. Similarly, Koumine, an indole alkaloid, restrained inflammatory cell infiltration and ameliorated the adipose-like lesions of hepatocytes in HFD-induced MAFLD rats by decreasing the secretion of Th17 cells and their cytokines and increasing the levels of Treg cells and anti-inflammatory cytokine IL-10 [57].…”

Section: Effects Of Th17-treg Cells Interaction On Mafldmentioning

confidence: 99%

Decoding the role of immune T cells: A new territory for improvement of metabolic‐associated fatty liver disease

Liu

Ding

Bai

et al. 2023

iMeta

View full text Add to dashboard Cite

Metabolic-associated fatty liver disease (MAFLD) is a new emerging concept and is associated with metabolic dysfunction, generally replacing the name of nonalcoholic fatty liver disease (NAFLD) due to heterogeneous liver condition and inaccuracies in definition. The prevalence of MAFLD is rising by year due to dietary changes, metabolic disorders, and no approved therapy, affecting a quarter of the global population and representing a major economic problem that burdens healthcare systems. Currently, in addition to the common causative factors like insulin resistance, oxidative stress, and lipotoxicity, the role of immune cells, especially T cells, played in MAFLD is increasingly being emphasized by global scholars. Based on the diverse classification and pathophysiological effects of immune T cells, we comprehensively analyzed their bidirectional regulatory effects on the hepatic inflammatory microenvironment and MAFLD progression. This interaction between MAFLD and T cells was also associated with hepatic-intestinal immune crosstalk and gut microbiota homeostasis. Moreover, we pointed out several T-cell-based therapeutic approaches including but not limited to adoptive transfer of T cells, fecal microbiota transplantation, and drug therapy, especially for natural products and Chinese herbal prescriptions. Overall, this study contributes to a better understanding of the important role of T cells played in MAFLD progression and corresponding therapeutic options and provides a potential reference for further drug development.

show abstract

Berberine attenuates non-alcoholic steatohepatitis by regulating chemerin/CMKLR1 signalling pathway and Treg/Th17 ratio

Cited by 15 publications

References 27 publications

Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling

Berberine Alleviates Acute Lung Injury in Septic Mice by Modulating Treg/Th17 Homeostasis and Downregulating NF-κB Signaling

Preventive and therapeutic effects of natural products and herbal extracts onnonalcoholic fatty liver disease/nonalcoholic steatohepatitis

Decoding the role of immune T cells: A new territory for improvement of metabolic‐associated fatty liver disease

Contact Info

Product

Resources

About