2018
DOI: 10.20428/yjms.12.1.a5
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Berberine Chloride and Hyperthermia Promote Osterix Expression and Suppress Cell Cycle Genes in Osteosarcoma Cells

Abstract: Objective: To investigate the effects of berberine chloride and hyperthermia on the expression of Osterix (Osx), Runt-related transcription factor 2 (RUNX-2), receptor activator of nuclear factor kappa-B ligand (RANKL), cyclin-dependent kinase 2 (CDK2), CDK4, interleukin (IL)-6 and IL-11 genes. Methods: Osteosarcoma cells (MG-63 cells) were treated with three different hyperthermia conditions for 1 h: two groups with mild, two with moderate and two with severe hyperthermia (at 39, 43 and 45 °C, respectively). … Show more

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