Berberine displays antitumor activity in esophageal cancer cells<i>in vitro</i>

Jiang, Shuxian; Qi, Bo; Yao, Wenjian; Li, Zhuoshi; Wei, Xiufeng; Zhao, Yanbin; Liu, Yuzhen; Zhao, Baosheng

doi:10.3748/wjg.v23.i14.2511

Cited by 44 publications

(42 citation statements)

References 23 publications

(31 reference statements)

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“…Berberine has diverse pharmacological effects and is normally used for the treatment of gastroenteritis [133,134]. It exhibits significant anti-cancer effects in a wide spectrum of cancers including ovarian, breast, esophageal, and thyroid cancers, leukemia, multiple myeloma, nasopharyngeal carcinoma, and neuroblastoma, through inducing cell cycle arrest and apoptosis, inhibiting metastasis and angiogenesis [135][136][137][138][139][140][141][142][143].…”

Section: Berberinementioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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Numerous natural products originated from Chinese herbal medicine exhibit anti-cancer activities, including antiproliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects, as well as regulate autophagy, reverse multidrug resistance, balance immunity, and enhance chemotherapy in vitro and in vivo. To provide new insights into the critical path ahead, we systemically reviewed the most recent advances (reported since 2011) on the key compounds with anti-cancer effects derived from Chinese herbal medicine (curcumin, epigallocatechin gallate, berberine, artemisinin, ginsenoside Rg3, ursolic acid, silibinin, emodin, triptolide, cucurbitacin B, tanshinone I, oridonin, shikonin, gambogic acid, artesunate, wogonin, β-elemene, and cepharanthine) in scientific databases (PubMed, Web of Science, Medline, Scopus, and Clinical Trials). With a broader perspective, we focused on their recently discovered and/or investigated pharmacological effects, novel mechanism of action, relevant clinical studies, and their innovative applications in combined therapy and immunomodulation. In addition, the present review has extended to describe other promising compounds including dihydroartemisinin, ginsenoside Rh2, compound K, cucurbitacins D, E, I, tanshinone IIA and cryptotanshinone in view of their potentials in cancer therapy. Up to now, the evidence about the immunomodulatory effects and clinical trials of natural anti-cancer compounds from Chinese herbal medicine is very limited, and further research is needed to monitor their immunoregulatory effects and explore their mechanisms of action as modulators of immune checkpoints.

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Section: Berberinementioning

confidence: 99%

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

et al. 2019

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“…Berberine has extensive pharmacological effects, including anti-hypertensive, anti-diabetic, anti-arrhythmia and anti-hyperlipidemic (3)(4)(5)(6). Recent studies have shown that berberine exerts antitumor effects in a variety of human cancer cells, such as breast cancer, hepatocellular carcinoma, leukemia, and esophageal cancer, both in vitro and in vivo, by suppressing proliferation, inducing apoptosis, arresting the cell cycle, and inhibiting invasion and metastasis (7)(8)(9)(10)(11)(12). In addition, it has been recently reported that berberine-induced autophagy has been observed in hepatic and colon cancer cells (13,14).…”

Section: Introductionmentioning

confidence: 99%

Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells

Yao

Wan

et al. 2018

Oncol Rep

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Increasing evidence shows that berberine has antitumor effects against a number of tumor cells. In the present study, we evaluated the effect of berberine on the proliferation of the human malignant pleural mesothelioma (MPM) cell line NCI-H2452, and explored the therapeutic potential and underlying mechanisms of this agent. Our results showed that berberine inhibited the proliferation of NCI-H2452 cells in a dose-and time-dependent manner and could induce apoptosis, possibly through a caspase-9-dependent intrinsic mitochondrial pathway. In addition, autophagy was induced by berberine, which was characterized by the accumulation of LC3-II and decreased p62 expression. We used inhibitors of apoptosis and autophagy, and an inducer of autophagy, to evaluate the significance of autophagy in berberine-induced cell death. The results demonstrated that apoptosis is the primary route through which berberine induces NCI-H2452 cell death. Berberine-induced autophagy may be an adaptive response to antitumor agents and have a protective role in MPM cells. Inhibition of autophagy enhanced berberine-induced apoptosis. Therefore, inhibition of autophagy may be an effective treatment strategy in the management of MPM. In conclusion, berberine is a potent antitumor agent for treating MPM, and it induces mitochondrial-mediated apoptosis and protective autophagy in human NCI-H2452 MPM cells.

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“…Furthermore, many studies have shown that BBR can be used for treating hypertension, cardiovascular diseases (due to antiheart failure, antiarrhythmia, and antiplatelet aggregation effects), neuronal diseases, gastrointestinal disorders, and several types of cancers [6][7][8][9][10]. e molecular and cellular mechanisms underlying the therapeutic effects of BBR, such as anti-inflammatory, antiapoptotic, antioxidative, and autophagy-promoting activities, have been found to involve some signaling pathways, such as the mitogen-activated protein kinase (MAPK) signaling, phosphatidylinositol-3 kinase/AKT/mammalian target of rapamycin (PI3K/Akt/mTOR), the Janus Kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3), and the nuclear factor erythroid 2-related factor 2/hemeoxygenase-1 (Nrf2/HO-1) pathways [11].…”

Section: Sources and Pharmacological Effects Of Berberine (Bbr)mentioning

confidence: 99%

Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers

Zhao

Liu

et al. 2019

BioMed Research International

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Berberine (BBR) is an isoquinoline alkaloid isolated from various types of plants, including those from the Berberidaceae, Ranunculaceae, and Papaveraceae families. It has long been used in traditional Chinese medicine for treating diarrhea and gastrointestinal disorders. The medicinal properties of BBR include antimicrobial, anti-inflammatory, antioxidative, lipid-regulatory, and antidiabetic actions. Importantly, the efficacy of BBR against cancers has been assessed in several experimental studies and clinical trials. Gastrointestinal (GI) cancers are a group of the most prevalent cancers worldwide that are associated with high morbidity and mortality, and their associated mortality has been increasing over the years. Thus, GI cancers have become a burden to the patients and health care systems. This review summarizes the cellular and molecular mechanisms underlying the therapeutic effects of BBR and explores its potential preventive and therapeutic applications against GI cancers.

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Berberine displays antitumor activity in esophageal cancer cellsin vitro

Cited by 44 publications

References 23 publications

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

Berberine induces mitochondrial‑mediated apoptosis and protective autophagy in human malignant pleural mesothelioma NCI‑H2452 cells

Preventive and Therapeutic Roles of Berberine in Gastrointestinal Cancers

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