Berberine hydrochloride alleviates imatinib mesylate – induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis

Song, Chengzhu; Li, Dongning; Zhang, Jie; Zhao, Xiaoyan

doi:10.1039/d2fo03331c

Cited by 19 publications

(8 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Berberine is mainly extracted from the stem and root of Coptidis Rhizoma and has been widely used to treat intestinal inflammation [ 35 , 36 ]. Song et al indicated that berberine potentially protected against imatinib mesylate-induced cardiotoxicity by inhibiting Nrf2-dependent ferroptosis [ 37 ]. Berberine inhibited ferroptosis by reducing ROS generation and lipid peroxidation in cardiac cells [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids

Wang,

Quan,

Xiu

et al. 2023

Chin Med

View full text Add to dashboard Cite

Background Gegen Qinlian decoction (GQD) is a classic prescription for treating ulcerative colitis (UC) in traditional Chinese medicine. However, the therapeutic mechanism has not been fully clarified. Purpose In the present study, we aimed to evaluate the role of ferroptosis-mediated IEC death in UC treated mice with GQD by using DSS-induced a colitis mouse model and RSL3-induced ferroptosis in intestinal organoids. Methods The effects of GQD on DSS-treated colitis were examined via daily body weight, DAI, colon length, HE staining, PAS staining, ZO-1 and Occludin immunohistochemical staining. Ferroptosis was determined by analysis of iron load, MDA, GSH, mitochondrial morphology, and expression of ferroptosis-associated proteins (GPX4, SLC7A11 and ACSL4). Results In vivo, GQD administration reduced body weight loss and DAI scores, increased colon length, and improved intestinal histological characteristics and epithelial barrier dysfunction. GQD administration obviously improved the levels of ferroptosis markers (iron load, MDA, GSH, and mitochondrial morphology) and the expression of ferroptosis-associated proteins (GPX4, SLC7A11 and ACSL4). Consistent with in vivo results, GQD administration partially reversed the levels of mtROS, Fe2+ and MDA in intestinal organoids induced by RSL3, and notably improved morphological destruction, histological damage and epithelial barrier dysfunction in organoids. Conclusions In this study, we demonstrated that ferroptosis was triggered in DSS-induced experimental colitis and that GQD adiministration could protect against colonic damage and intestinal epithelial barrier dysfunction by inhibiting ferroptosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids

Wang,

Quan,

Xiu

et al. 2023

Chin Med

View full text Add to dashboard Cite

show abstract

“…Studies have shown that Nrf2 activation plays a neuroprotective role in neurological diseases such as Parkinson’s disease ( Bento-Pereira and Dinkova-Kostova, 2021 ) and multiple sclerosis ( Montes Diaz et al, 2018 ). Nrf2 can regulate glucose uptake and metabolism of neurons ( Esteras et al, 2023 ), autophagy ( Li et al, 2021 ), ferroptosis ( Song et al, 2023 ), inflammation ( Wang J. et al, 2023 ), mitochondrial function ( Jamwal et al, 2021 ), and promote energy metabolism ( Esteras et al, 2023 ), which helps to maintain the health and survival of neurons. For example, CMPB can improve learning and memory impairment caused by fatigue by regulating PI3K/NRF2/HO-1 signal pathway, scavenging free radicals and fatigue metabolites, increasing the content of glycogen and regulating the content of central neurotransmitters in the body ( Bai et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Ma,

Wang,

2023

Front. Genet.

View full text Add to dashboard Cite

Background: Nrf2 plays a pivotal role in governing the antioxidant defense system, triggering the transcription of diverse genes involved in cellular protection. Its role in mitigating oxidative damage and modulating inflammatory processes has made Nrf2 an attractive target for therapeutic interventions. Despite the growing interest in Nrf2 research, a bibliometric analysis is relatively rare. This study aimed to clarify Nrf2’s role in multiple diseases, identify emerging trends and hotspots using bibliometric analysis, and provide valuable insights and potential directions for future therapeutic interventions.Methods: The Science Citation Index of Web of Science Core library from 2000 to 2022 was searched on 22 October 2022. Use Microsoft Excel, CiteSpace, Bibliometrix, and VOS viewers for data collection and visualization of research focus and trends.Results: A vast collection of 22,040 research studies on Nrf2 published between 2000 and 2022 were identified. Nrf2 research has seen significant growth globally from 2000 to 2022. China leaded in publication numbers (9,623, 43.66%), while the United States dominated in citation frequency with 261,776 citations. China Medical University was the most productive institutions (459, 2.08%). Masayuki Yamamoto topped in publications (307), while Itoh K. ranked first in citations with 3669. Free Radical Biology and Medicine was the journal with the most studies and citations on Nrf2 (613, 29,687 citations). The analysis of keyword clustering enhanced the categorization of topics and can be summarized as oxidative stress, cancer, disorders in glycolipid metabolism, inflammation, and neurological conditions.Conclusion: China and the United States are the pioneers in Nrf2 research. Recently, there has been a comprehensive exploration of Nrf2 involving both experimental and clinical aspects, as well as mechanisms and therapeutic applications. Investigating novel molecular mechanisms, including NF-κB, Ho1, and Keap1, and developing enhanced, targeted Nrf2 activators or inhibitors to uncover the interplay among cancer, glycolipid metabolic disorder, inflammation, and neurological disorders will be upcoming trends and hotspots.

show abstract

“…In addition, many traditional Chinese medicine monomers and preparations have shown good effects on inhibiting ferroptosis by targeting NRF2-related pathway. Berberine hydrochloride increased cell viability and MMP by inhibiting NRF2 [ 205 ] or by reducing ROS generation and lipid peroxidation [ 206 ], showing a good inhibitory effect on ferroptosis. Britanin can alleviate ferroptosis by activating AMPK/GSK3β/NRF2 signaling pathway and up-regulating GPX4 [ 207 ].…”

Section: Targeted Interventions and Prospectsmentioning

confidence: 99%

Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

Yan

Xie

Liu

et al. 2023

Diabetol Metab Syndr

View full text Add to dashboard Cite

Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead to heart insufficiency, heart failure and even death. Currently, the pathogenesis of DC is unclear, and clinical intervention is mainly symptomatic therapy and lacks effective intervention objectives. Iron overdose mediated cell death, also known as ferroptosis, is widely present in the physiological and pathological processes of diabetes and DC. Iron is a key trace element in the human body, regulating the metabolism of glucose and lipids, oxidative stress and inflammation, and other biological processes. Excessive iron accumulation can lead to the imbalance of the antioxidant system in DC and activate and aggravate pathological processes such as excessive autophagy and mitochondrial dysfunction, resulting in a chain reaction and accelerating myocardial and microvascular damage. In-depth understanding of the regulating mechanisms of iron metabolism and ferroptosis in cardiovascular vessels can help improve DC management. Therefore, in this review, we summarize the relationship between ferroptosis and the pathogenesis of DC, as well as potential intervention targets, and discuss and analyze the limitations and future development prospects of these targets.

show abstract

Berberine hydrochloride alleviates imatinib mesylate – induced cardiotoxicity through the inhibition of Nrf2-dependent ferroptosis

Abstract: The underlying mechanisms of protective effects of Ber on IMA-induced cardiotoxicity.

Cited by 19 publications

References 45 publications

Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids

Gegen Qinlian decoction (GQD) inhibits ulcerative colitis by modulating ferroptosis-dependent pathway in mice and organoids

Insight into Nrf2: a bibliometric and visual analysis from 2000 to 2022

Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy

Contact Info

Product

Resources

About