2014
DOI: 10.1124/jpet.114.212795
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Berberine Hydrochloride Prevents Postsurgery Intestinal Adhesion and Inflammation in Rats

Abstract: Intestinal adhesion, characterized by connection of the loops of the intestine with other abdominal organs by fibrous tissue bands, remains an inevitable event of abdominal operations and can cause a number of complications. Berberine hydrochloride (berberine), a natural plant alkaloid derived from Chinese herbal medicine, is characterized by diverse pharmacological effects, such as anticancer and lower elevated blood glucose. This study is designed to investigate the effects of berberine on adhesion and infla… Show more

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Cited by 90 publications
(56 citation statements)
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References 51 publications
(58 reference statements)
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“…In IBD and experimental colitis, monocytes in blood are recruited to the mucosa and differentiate into activated macrophages that produce pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα), interleukin (IL)-1 and IL-6278. Activation of NF-κB is thought as a strong inducer of these proinflammatory cytokine expressions910, and activated NF-κB has been demonstrated in colonic macrophages of patients with IBD.…”
mentioning
confidence: 99%
“…In IBD and experimental colitis, monocytes in blood are recruited to the mucosa and differentiate into activated macrophages that produce pro-inflammatory cytokines, such as tumor necrosis factor α (TNFα), interleukin (IL)-1 and IL-6278. Activation of NF-κB is thought as a strong inducer of these proinflammatory cytokine expressions910, and activated NF-κB has been demonstrated in colonic macrophages of patients with IBD.…”
mentioning
confidence: 99%
“…Berberine also exhibits anti-infl amma-. Berberine also exhibits anti-inflammatory effects on patients with acute coronary syndrome that have experienced percutaneous coronary intervention (26). Additionally, berberine prevents postsurgical intestinal adhesion and inhibits inflammation in a rat model by inhibiting the transforming growth factor β-activated kinase 1 (TAK1)/Jun N-terminal kinase and TAK1/NF-κB signaling pathways (22).…”
Section: Discussionmentioning
confidence: 99%
“…Several important signaling pathways are implicated in this function (e.g. TGF-β/Smad, HGF/Met, and PDGF/PDGFR) [107] (Figure 1). …”
Section: Immunosuppressive Effects Of Cafsmentioning
confidence: 99%