Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma

Li, Zhenghao; Zheng, Jie; Zhang, Ning; Li, Chengde

doi:10.1080/02770903.2016.1180530

Cited by 62 publications

(30 citation statements)

References 47 publications

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“…Several pharmaceutical tactics, such as formulation with permeability enhancers, P-gp inhibitors, muco-adhesive agents have been attempted to eradicate pharmaceutical incompetence of berberine; however, application of nanotechnology has been found to be the most promising tool to improve oral bioavailability and therapeutic efficacy of berberine [249]. Dendrimers-encapsulated berberine, berberine-assembled polymer-lipid hybrid nanoparticles, and chitosan-coated nanoliposomes of berberine have been reported to facilitate oral delivery of berberine with improved pharmaceutical attributes [250][251][252].…”

Section: Berberinementioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Berberinementioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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“…While, berberine, baicalin, baicalein, wogonoside, wogonin and geniposide have been identified, and been considered as the main bioactive components in HLJDD [27, 29]. In those identified components, berberine and baicalin have been reported to possess anti-inflammatory effects and have been used to treat many diseases [30]. Ni et al reported that the berberine exhibited a strong renoprotective effects in in vivo diabetic nephropathy model [31].…”

Section: Introductionmentioning

confidence: 99%

Reno-protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice

Nie

Deng

Xiang

et al. 2016

BMC Complement Altern Med

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BackgroundHuang Lian Jie Du Decoction (HLJDD), a very famous traditional Chinese medicinal prescription, has been used for heat dissipation and detoxification in China. This study was aimed to evaluate the reno-protective effects of HLJDD against lupus nephritis (LN) in vivo in MRL/lpr mice.MethodsAnimals were administered orally every day for eight consecutive weeks except the mice of normal group and model group. Organ indexes, serum interleukin-6 (IL-6), interleukin-10 (IL-10), interferon-gamma (IFN-γ) and the anti-double stranded DNA (anti-dsDNA) antibody were tested, respectively. Creatinine (Cr), blood urea nitrogen (BUN) and urine protein were measured for renal function evaluation. The expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT 3) in kidney tissue was observed by western blot (WB) and immunohistochemical (IHC) method. Meanwhile, histopathological changes in the renal were studied by hematoxylin-eosin (H&E) staining.ResultsThe mice of HLJDD-treated group exhibited a significant reduced mortality (p < 0.05), serum anti-dsDNA level (p < 0.05) and renal immune complex deposition (p < 0.05), compared with the untreated MRL/lpr mice. In addition, HLJDD treatment remarkably reduced the levels of BUN, Cr, proteinuria (p < 0.01) and the levels of inflammatory cytokines such as IL-6, IL-10 and IFN-γ (p < 0.01). Moreover, HLJDD significantly suppressed the phosphorylations of STAT 3 (p < 0.05) and the renal pathological changes.ConclusionsThe study implied that HLJDD may be a potential agent for the therapy of LN, and the down-regulated p-STAT 3 expression suggesting that it may be one of the LN therapy targets for HLJDD.

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“…Of these, berberine, pyrogallol, catechin dimers, and resveratrol 3-O-β-glucoside have shown anti-inflammatory effects in various studies. Berberine was observed to inhibit the production of proinflammatory cytokines interleukin (IL)-6 and chemokines IL8 in HaCaT stimulated with sulfur mustard (Lang et al, 2018 ) and their anti-inflammatory effects have been linked to the inhibition of the nuclear factor-κB (NF-κB) signaling pathway (Li et al, 2016 ). Catechin dimers (Andre et al, 2012 ) and resveratrol 3-O-β-glucoside (Potapovich et al, 2011 ) have also been shown to inhibit NF-κB activation in TNF- α-stimulated-NF-κB/SEAP (Secreted alkaline phosphatase) HEK 293 cell lines and TNF-α-plus-IFN-γ-stimulated primary human keratinocytes.…”

Section: Resultsmentioning

confidence: 99%

Disentangling the Complexity of a Hexa-Herbal Chinese Medicine Used for Inflammatory Skin Conditions—Predicting the Active Components by Combining LC-MS-Based Metabolite Profiles and in vitro Pharmacology

Chang¹,

Lane

Yang³

et al. 2018

Front. Pharmacol.

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Objectives: The purpose of this study is to investigate the anti-inflammatory activity of a hexa-herbal Chinese formula (HHCF) using spontaneously immortalized human epidermal keratinocytes (HaCaT) and to predict the active components by correlating the LC-MS-based metabolite profiles of the HHCF and its 12 varied formulae with their anti-inflammatory activity using partial least-squares regression analysis.Methods: The HHCF comprises the rootstock of Scutellaria baicalensis, Rheum tanguticum, Sophora flavescens, the root bark of Dictamnus dasycarpus, the bark of Phellodendron chinense, and the fruit of Kochia scoparia in equal proportions. Its 12 varied formulae were developed by uniform design with varied proportions of the component botanical drugs. The decoctions of the HHCF and its 12 varied formulae were profiled using liquid chromatography (LC) combined with triple quadrupole mass spectrometry (MS) and their effects on tumor necrosis factor (TNF)-α -plus-interferon (IFN)-γ-induced C-C motif chemokine ligand 17 (CCL17) production in HaCaT were investigated. Partial least-squares regression analysis was conducted to assess the relationship between the LC-MS-based metabolite profiles of the decoctions to anti-CCL17 production in HaCaT.Results: Compounds with potential to promote anti-CCL17 production in HaCaT were identified (e.g., berberine, pyrogallol and catechin dimers) as a result of the developed model and their potential to act as anti-inflammatory agents were also supported by relevant literature.Conclusion: This promising approach should assist in the screening process of active components from complex Chinese herbal preparations and will better inform the necessary pharmacological experiments to take forward.

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Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma

Abstract: The findings suggested a therapeutic potential of berberine on OVA- induced airway inflammation. The ameliorative effects on the OVA-induced airway inflammation might be associated with the inhibition of the NF-κB signaling pathway.

Cited by 62 publications

References 47 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Reno-protective effect and mechanism study of Huang Lian Jie Du Decoction on lupus nephritis MRL/lpr mice

Disentangling the Complexity of a Hexa-Herbal Chinese Medicine Used for Inflammatory Skin Conditions—Predicting the Active Components by Combining LC-MS-Based Metabolite Profiles and in vitro Pharmacology

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