Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis

He, Yan; Yuan, Xiaoming; Zuo, Hao; Li, Xiangwei; Sun, Ying; Feng, Aiwen

doi:10.1016/j.lfs.2019.116697

Cited by 16 publications

(18 citation statements)

References 45 publications

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“…The nutraceutical berberine, a compound found in various Chinese medicinal herbs, can likewise activate AMPK and is widely employed for diabetes management in China (46)(47)(48). Not surprisingly, both metformin and berberine are reported to have favorable effects on the intestinal barrier and tight junction maintenance (49)(50)(51)(52)(53)(54).…”

Section: Berberine and Scfa-induced Ampk Activity Promotes Tight Junction Formationmentioning

confidence: 99%

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

McCarty

Lerner

2021

Advances in Nutrition

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Impairment of intestinal barrier function is linked to certain pathologies and to aging, and can be a cause of bacterial infections, systemic and hepatic inflammation, food allergies, and autoimmune disorders. The formation and maintenance of intestinal tight junctions is supported by glucagon-like peptide-2 (GLP-2), which via insulin-like growth factor I activity boosts phosphoinositide 3-kinase/Akt/mammalian target of rapamycin complex 1 (PI3K/Akt/mTORC1) signaling in enterocytes. 5′-AMP-activated protein kinase (AMPK) activity as well as estrogen receptor-β (ERβ) activity are also protective in this regard. Conversely, activation of mitogen-activated protein kinases (MAPKs) and cellular Src (c-Src) under inflammatory conditions can induce dissociation of tight junctions. Hence, nutraceuticals that promote GLP-2 secretion from L cells—effective pre/probiotics, glycine, and glutamine—as well as diets rich in soluble fiber or resistant starch, can support intestinal barrier function. AMPK activators—notably berberine and the butyric acid produced by health-promoting microflora—are also beneficial in this regard, as are soy isoflavones, which function as selective agonists for ERβ. The adverse impact of MAPK and c-Src overactivation on the intestinal barrier can be combatted with various antioxidant measures, including phycocyanobilin, phase 2–inducer nutraceuticals, and N-acetylcysteine. These considerations suggest that rationally designed functional foods or complex supplementation programs could have clinical potential for supporting and restoring healthful intestinal barrier function.

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Section: Berberine and Scfa-induced Ampk Activity Promotes Tight Junction Formationmentioning

confidence: 99%

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

McCarty

Lerner

2021

Advances in Nutrition

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“…Berberine can reduce intestinal damage caused by LPS, through increasing the activating of SOD and GSH-Px and inhibiting TLR4 and NF-κB in the ileum (Zhang et al, 2011). Furthermore, berberine can also induce Zrt-Irt-like protein 14 expression to protect the intestinal barrier in sepsis (He et al, 2019), and ameliorates sepsisinduced reduction in intestinal vascular barrier permeability caused by sepsis by modulating the ApoM/S1P pathway . Berberine has also been shown to protect the intestinal mucosal barrier by mediating Toll-like receptors .…”

Section: Regulation Of Intestinal Barriermentioning

confidence: 99%

Traditional Chinese Medicine: A promising strategy to regulate inflammation, intestinal disorders and impaired immune function due to sepsis

Wang

Chen

et al. 2022

Front. Pharmacol.

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Sepsis is described as a dysregulation of the immune response to infection, which leads to life-threatening organ dysfunction. The interaction between intestinal microbiota and sepsis can’t be ignored. Furthermore, the intestinal microbiota may regulate the progress of sepsis and attenuate organ damage. Thus, maintaining or restoring microbiota may be a new way to treat sepsis. Traditional Chinese medicine (TCM) assumes a significant part in the treatment of sepsis through multi-component, multi-pathway, and multi-targeting abilities. Moreover, TCM can prevent the progress of sepsis and improve the prognosis of patients with sepsis by improving the imbalance of intestinal microbiota, improving immunity and reducing the damage to the intestinal barrier. This paper expounds the interaction between intestinal microbiota and sepsis, then reviews the current research on the treatment of sepsis with TCM, to provide a theoretical basis for its clinical application.

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“…It is worth mentioning that the zinc effects seen in the LLC-PK 1 renal cell culture model were potentiated by simultaneous treatment with the flavonoid quercetin [ 326 ]. The nutraceutical berberine—itself an effective modulator of GI epithelial TJs and enhancer of barrier function—may have its beneficial barrier effects mediated by increased intracellular zinc [ 327 ].…”

Section: Can Elevated Micronutrient Levels (Supplementation) Improve ...mentioning

confidence: 99%

Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy

DiGuilio

Rybakovsky

Abdavies

et al. 2022

IJMS

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The published literature makes a very strong case that a wide range of disease morbidity associates with and may in part be due to epithelial barrier leak. An equally large body of published literature substantiates that a diverse group of micronutrients can reduce barrier leak across a wide array of epithelial tissue types, stemming from both cell culture as well as animal and human tissue models. Conversely, micronutrient deficiencies can exacerbate both barrier leak and morbidity. Focusing on zinc, Vitamin A and Vitamin D, this review shows that at concentrations above RDA levels but well below toxicity limits, these micronutrients can induce cell- and tissue-specific molecular-level changes in tight junctional complexes (and by other mechanisms) that reduce barrier leak. An opportunity now exists in critical care—but also medical prophylactic and therapeutic care in general—to consider implementation of select micronutrients at elevated dosages as adjuvant therapeutics in a variety of disease management. This consideration is particularly pointed amidst the COVID-19 pandemic.

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Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis

Cited by 16 publications

References 45 publications

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

Perspective: Prospects for Nutraceutical Support of Intestinal Barrier Function

Traditional Chinese Medicine: A promising strategy to regulate inflammation, intestinal disorders and impaired immune function due to sepsis

Micronutrient Improvement of Epithelial Barrier Function in Various Disease States: A Case for Adjuvant Therapy

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