Berberine is as effective as the anti-obesity drug Orlistat in ameliorating betel-nut induced dyslipidemia and oxidative stress in mice

Pharmacokinetic of berberine, the main constituent of Berberis vulgaris L.: A comprehensive review

“…A major constituent of B. vulgaris is berberine which is an isoquinoline alkaloid (a 5,6‐dihydrodibenzo[a,g]quinolizinium) that has various uses in Ayurveda and Traditional Chinese Medicine (McCubrey et al, 2022; Sadeghnia, Kolangikhah, Asadpour, Forouzanfar, & Hosseinzadeh, 2017; Sadeghnia, Taji, Forouzanfar, & Hosseinzadeh, 2017; Xia et al, 2022). Berberine is also present in many other plants including further species of Berberis ( B. aristata L., B. croatica L. , B. aquifolium L.)., Coptis ( Coptis chinensis L., Coptis japonica L.), and Hydrastis ( Hydrastis Canadensis L.) (Imenshahidi & Hosseinzadeh, 2019) and has many pharmacologic properties (Jang, Piao, Kim, Kwon, & Park, 2008), such as antioxidant (Shou et al, 2022), anti‐microbial (Tian et al, 2022), antiinflammatory (Deng et al, 2022), anticancer (Zhao, Roy, Wang, & Goel, 2022), anti‐diabetes (Zhang et al, 2022), anti‐dyslipidemia (Zhao et al, 2021), anti‐obesity (Bhattacharjee, Nath, & Choudhury, 2021), and anti‐metabolic syndrome (Tabeshpour, Imenshahidi, & Hosseinzadeh, 2017). A relatively large number of clinical studies have shown that berberine can display its therapeutic activities in the treatment of different diseases including diabetes, hyperlipidemia, cancer, hypertension, stroke, metabolic syndrome, polycystic ovarian syndrome, and liver disease in human subjects.…”