Berberine modulates the immunometabolism and differentiation of CD4+ T cells alleviating experimental arthritis by suppression of M1-exo-miR155

Cai, Wei-wei; Gao, Yi; Cheng, Jing-wen; Yu, Yun; Zong, Shi-ye; Li, Yu-hui; Wang, Ying; Song, Yi-ning; Mao, Xiao-ting; Guan, Jie; Xu, Long; Zhang, Die-yu; Li, Kai; Wei, Fang

doi:10.1016/j.phymed.2023.155255

Cited by 3 publications

(1 citation statement)

References 38 publications

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“…Notably, in rheumatoid arthritis, macrophages and T cells jointly mediate the inflammatory cascade response. Exosomes derived from M1 macrophages can deliver miR-155 to CD4 + T cells to mediate immune metabolic disorder, and BBR reportedly inhibits this delivery process, thereby regulating the immune metabolism of CD4 + T cells (Cai et al, 2024). BBR can also impact the metabolic mechanisms of certain oral and dental diseases.…”

Section: Other Metabolism-related Diseasesmentioning

confidence: 99%

Molecular mechanisms, targets and clinical potential of berberine in regulating metabolism: a review focussing on databases and molecular docking studies

Sun,

Yang,

et al. 2024

Front. Pharmacol.

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Background: Metabolic imbalance is the common basis of many diseases. As natural isoquinoline alkaloid, berberine (BBR) has shown great promise in regulating glucose and lipids metabolism and treating metabolic disorders. However, the related mechanism still lacks systematic research.Aim: To discuss the role of BBR in the whole body’s systemic metabolic regulation and further explore its therapeutic potential and targets.Method: Based on animal and cell experiments, the mechanism of BBR regulating systemic metabolic processes is reviewed. Potential metabolism-related targets were summarized using Therapeutic Target Database (TTD), DrugBank, GeneCards, and cutting-edge literature. Molecular modeling was applied to explore BBR binding to the potential targets.Results: BBR regulates the whole-body metabolic response including digestive, circulatory, immune, endocrine, and motor systems through adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR), sirtuin (SIRT)1/forkhead box O (FOXO)1/sterol regulatory element-binding protein (SREBP)2, nuclear factor erythroid 2-related factor (Nrf) 2/heme oxygenase (HO)-1, and other signaling pathways. Through these reactions, BBR exerts hypoglycemic, lipid-regulating, anti-inflammatory, anti-oxidation, and immune regulation. Molecular docking results showed that BBR could regulate metabolism targeting FOXO3, Nrf2, NAD(P)H quinone oxidoreductase 1 (NQO1), glutathione peroxidase (Gpx) 4 and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA). Evaluating the target clinical effects, we found that BBR has the therapeutic potential of anti-aging, anti-cancer, relieving kidney disease, regulating the nervous system, and alleviating other chronic diseases.Conclusion: This review elucidates the interaction between potential targets and small molecular metabolites by exploring the mechanism of BBR regulating metabolism. That will help pharmacologists to identify new promising metabolites interacting with these targets.

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Section: Other Metabolism-related Diseasesmentioning

confidence: 99%

Molecular mechanisms, targets and clinical potential of berberine in regulating metabolism: a review focussing on databases and molecular docking studies

Sun,

Yang,

et al. 2024

Front. Pharmacol.

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Prussian Blue Nanostructure Conjugated Berberine Improves Inflammatory Response of Rheumatoid Arthritis by Suppressing Necroptosis

Wang,

Xu,

Wang

et al. 2024

ACS Appl. Nano Mater.

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Rheumatoid arthritis has serious consequences for human health. Drugs can relieve the symptoms of some patients, but they exert significant toxic side effects. We loaded berberine into the Prussian blue nanostructure, synthesizing BRB-PB composites. It improves photothermal properties and exhibits potent anti-inflammatory and antioxidant effects. BRB-PB composites inhibited RIPK1/RIPK3/MLKL signaling pathway activation in RA synovial tissue, suggesting a unique molecular mechanism that reduces the occurrence of necroptosis and improves RA symptoms. Rapid metabolism and excellent biocompatibility of BRB-PB composites enhanced their safety and efficacy.

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Targeting dysregulated intracellular immunometabolism within synovial microenvironment in rheumatoid arthritis with natural products

Hu,

Lin,

Tang

et al. 2024

Front. Pharmacol.

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Immunometabolism has been an emerging hotspot in the fields of tumors, obesity, and atherosclerosis in recent decades, yet few studies have investigated its connection with rheumatoid arthritis (RA). In principle, intracellular metabolic pathways upstream regulated by nutrients and growth factors control the effector functions of immune cells. Dynamic communication and hypermetabolic lesions of immune cells within the inflammatory synovial microenvironment contributes to the development and progression of RA. Hence, targeting metabolic pathways within immune subpopulations and pathological cells may represent novel therapeutic strategies for RA. Natural products constitute a great potential treasury for the research and development of novel drugs targeting RA. Here, we aimed to delineate an atlas of glycolysis, lipid metabolism, amino acid biosynthesis, and nucleotide metabolism in the synovial microenvironment of RA that affect the pathological processes of synovial cells. Meanwhile, therapeutic potentials and pharmacological mechanisms of natural products that are demonstrated to inhibit related key enzymes in the metabolic pathways or reverse the metabolic microenvironment and communication signals were discussed and highlighted.

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Berberine modulates the immunometabolism and differentiation of CD4+ T cells alleviating experimental arthritis by suppression of M1-exo-miR155

Cited by 3 publications

References 38 publications

Molecular mechanisms, targets and clinical potential of berberine in regulating metabolism: a review focussing on databases and molecular docking studies

Molecular mechanisms, targets and clinical potential of berberine in regulating metabolism: a review focussing on databases and molecular docking studies

Prussian Blue Nanostructure Conjugated Berberine Improves Inflammatory Response of Rheumatoid Arthritis by Suppressing Necroptosis

Targeting dysregulated intracellular immunometabolism within synovial microenvironment in rheumatoid arthritis with natural products

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