Berberine promotes IGF2BP3 ubiquitination by TRIM21 to induce G1/S phase arrest in colorectal cancer cells

F-box proteins and gastric cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects

“…Since the substrate specificity of UPS is achieved by E3 ligases, such proteins offer new avenues for tumor therapy. Interestingly, some studies found that FBPs can impact the metabolism and clearance rate of drugs by regulating the expression and activity of drug-metabolizing enzymes, thereby modulating the efficacy and toxicity of drugs and enhancing the effectiveness and safety of drug therapy 58 , 59 . Furthermore FBPs also can influence the therapeutic effects of drugs by modulating the degradation rate of target proteins 60 .…”

Regulatory mechanisms and therapeutic implications of insulin-like growth factor 2 mRNA-binding proteins, the emerging crucial m6A regulators of tumors

“…For instance, overexpressed FBXO45 interacts with IGF2BP1 and facilitates its activation, leading to liver tumorigenesis 49 . Contrarily, tripartite motif-containing protein 21 (TRIM21), another E3 ubiquitin ligase, expedites IGF2BP3 decay via the UPS, arresting the growth of CRC 105 . SUMOylation can facilitate numerous pivotal physiological and pathological processes by helping maintain protein stability.…”

Targeting RNA‐binding proteins for cancer therapy

“…IGF2BPs could be regulated by multiple enzymes including E3s and DUBs in the ubiquitin system (Figure 1B). 7 – 15 …”

“…IGF2BPs could be regulated by multiple enzymes including E3s and DUBs in the ubiquitin system (Figure 1B). [7][8][9][10][11][12][13][14][15] In a paper recently published in Clin Transl Med, Sun et al 16 reported that IGF2BP3 was a new substrate of the Parkin E3 ligase in cervical cancer cells and tissues through proteomics and biochemical experiments. In vitro and in vivo experiments demonstrated that Parkin ubiquitinated IGF2BP3 at K213 and promoted its proteasomal degradation.…”