Berberine Reverses Breast Cancer Multidrug Resistance Based on Fluorescence Pharmacokinetics <i>In Vitro</i> and <i>In Vivo</i>

Qian, Ke; Tang, Chaoyuan; Chen, Liying; Zheng, Shaokuan; Zhao, Yue; Ma, Liang; Xu, Li; Fan, Liping; Yu, Jianan; Tan, Hongsheng; Yalan, Sun; Song, Lili; Yang, Lu; Liu, Qi; Liu, Yun; Xiong, Yang

doi:10.1021/acsomega.0c06288

Cited by 36 publications

(19 citation statements)

References 35 publications

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“…In addition, the combination of berberine with chemotherapeutic drugs (cisplatin and 5-fluorouracil) showed synergistic effects on suppressing breast cancer cell proliferation, thus inducing apoptosis and inhibiting cell migration [ 40 , 41 ]. Anyway, berberine could reverse the multidrug resistance of breast cancer by suppressing the efflux function of ATP-binding cassette transporters [ 42 ].…”

Section: Effects Of Berberine On Cancersmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.

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Section: Effects Of Berberine On Cancersmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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“…Studies have shown that BBR can increase the level of reactive oxygen species (ROS) to induce apoptosis in lapatinib-resistant cells and reverse the drug resistance of breast cancer cells ( Zhang et al, 2016 ). In addition, BBR and Dox synergistically enhanced the inhibitory effect on cancer cells by reducing P-gp and multidrug resistance protein 1 expression with the best BBR/Dox ratio of = 2:1 ( Qian et al, 2021 ).…”

Section: Mechanisms Of Bbr Anticancer Effectsmentioning

confidence: 99%

Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

et al. 2022

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Cancer is the leading cause of death and one of the greatest barriers to increased life expectancy worldwide. Currently, chemotherapy with synthetic drugs remains one of the predominant ways for cancer treatment, which may lead to drug resistance and normal organ damage. Increasing researches have suggested that apoptosis, a type of programmed cell death, is a promising way for cancer therapy. Furthermore, natural products are important sources for finding new drugs with high availability, low cost and low toxicity. As a well-known isoquinoline alkaloid, accumulating evidence has revealed that berberine (BBR) exerts potential pro-apoptotic effects on multiple cancers, including breast, lung, liver, gastric, colorectal, pancreatic, and ovarian cancers. The related potential signal pathways are AMP-activated protein kinase, mitogen-activated protein kinase, and protein kinase B pathways. In this review, we provide a timely and comprehensive summary of the detailed molecular mechanisms of BBR in treating three types of cancer (breast, lung and liver cancer) by inducing apoptosis. Furthermore, we also discuss the existing challenges and strategies to improve BBR’s bioavailability. Hopefully, this review provides valuable information for the comprehension of BBR in treating three types of cancer and highlight the pro-apoptotic effects of BBR, which would be beneficial for the further development of this natural compound as an effective clinical drug for treating cancers.

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“…BBR is also used as a potential agent for breast therapy due to its ability to reverse MDR. Therefore, combinations of natural products showed robust effects in reducing invasion, migration, and the EMT process [ 122 , 123 ].…”

Section: Synergistic Approach Of Natural Products Against Bcmentioning

confidence: 99%

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

et al. 2022

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Breast cancer (BC) is the second leading cause of death among women, and it has become a global health issue due to the increasing number of cases. Different treatment options, including radiotherapy, surgery, chemotherapy and anti-estrogen therapy, aromatase inhibitors, anti-angiogenesis drugs, and anthracyclines, are available for BC treatment. However, due to its high occurrence and disease progression, effective therapeutic options for metastatic BC are still lacking. Considering this scenario, there is an urgent need for an effective therapeutic strategy to meet the current challenges of BC. Natural products have been screened as anticancer agents as they are cost-effective, possess low toxicity and fewer side effects, and are considered alternative therapeutic options for BC therapy. Natural products showed anticancer activities against BC through the inhibition of angiogenesis, cell migrations, proliferations, and tumor growth; cell cycle arrest by inducing apoptosis and cell death, the downstream regulation of signaling pathways (such as Notch, NF-κB, PI3K/Akt/mTOR, MAPK/ERK, and NFAT-MDM2), and the regulation of EMT processes. Natural products also acted synergistically to overcome the drug resistance issue, thus improving their efficacy as an emerging therapeutic option for BC therapy. This review focused on the emerging roles of novel natural products and derived bioactive compounds as therapeutic agents against BC. The present review also discussed the mechanism of action through signaling pathways and the synergistic approach of natural compounds to improve their efficacy. We discussed the recent in vivo and in vitro studies for exploring the overexpression of oncogenes in the case of BC and the current status of newly discovered natural products in clinical investigations.

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Berberine Reverses Breast Cancer Multidrug Resistance Based on Fluorescence Pharmacokinetics In Vitro and In Vivo

Cited by 36 publications

References 35 publications

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Apoptosis Induction, a Sharp Edge of Berberine to Exert Anti-Cancer Effects, Focus on Breast, Lung, and Liver Cancer

A Review of Twenty Years of Research on the Regulation of Signaling Pathways by Natural Products in Breast Cancer

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