Berberis alkaloids. XXVI. An investigation of the alkaloids ofBerberis amurensis

Yusupov, Marat; Каримов, А.; Shakirov, R.; Горовой, П. Г.; Faskhutdinov, M. F.; Левкович, М. Г.; Абдуллаев, Н. Д.

doi:10.1007/bf00630534

Cited by 10 publications

(6 citation statements)

References 3 publications

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“…Several other analogues of 4 have been isolated from various Berberis species, however, no information is available concerning their activities at the MOR. We investigated nummularine 39 , bernumidine, bernumicine 40 , and bernumine 41 , amenurine, and O -acetylamenurine 42 within our docking workflow, respectively. Our results predicted an agonist MOR activity for bernumine, amenurine, and O -acetylamenurine.…”

Section: Discussionmentioning

confidence: 99%

“…Further investigations are therefore required to elucidate the mechanisms underlying the effects of Berberis vulgaris extracts and to identify the active constituents. Additionally, Berberis nummularia 39 40 41 and Berberis amurensis 42 containing nummularine 39 , bernumidine, bernumicine 40 , bernumine 41 , amenurine, and O -acetylamenurine 42 would be particularly interesting for further investigations. Thus, despite the low binding affinity at the MOR, the molecules identified as MOR ligands in this study represent an interesting starting point for further chemical optimization due to their structural novelty.…”

Section: Discussionmentioning

confidence: 99%

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μ Opioid receptor: novel antagonists and structural modeling

Kaserer

Lantero

Schmidhammer

et al. 2016

Sci Rep

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The μ opioid receptor (MOR) is a prominent member of the G protein-coupled receptor family and the molecular target of morphine and other opioid drugs. Despite the long tradition of MOR-targeting drugs, still little is known about the ligand-receptor interactions and structure-function relationships underlying the distinct biological effects upon receptor activation or inhibition. With the resolved crystal structure of the β-funaltrexamine-MOR complex, we aimed at the discovery of novel agonists and antagonists using virtual screening tools, i.e. docking, pharmacophore- and shape-based modeling. We suggest important molecular interactions, which active molecules share and distinguish agonists and antagonists. These results allowed for the generation of theoretically validated in silico workflows that were employed for prospective virtual screening. Out of 18 virtual hits evaluated in in vitro pharmacological assays, three displayed antagonist activity and the most active compound significantly inhibited morphine-induced antinociception. The new identified chemotypes hold promise for further development into neurochemical tools for studying the MOR or as potential therapeutic lead candidates.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

μ Opioid receptor: novel antagonists and structural modeling

Kaserer

Lantero

Schmidhammer

et al. 2016

Sci Rep

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“…Berberubine, oxyacanthine, pseudopalmatine, amurenine (Yusupov et al, 1993b) B. aristata DC. Stem bark Berberine phenoxide, ketoberberine benzoate A, ketoberberine benzoate B (Ahamad et al, 2014) Root and stem bark…”

Section: Young Shootmentioning

confidence: 99%

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

et al. 2020

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“…In trunk: Triterpenoids: 2 , 3 , 19 -trihydroxy-urs-12-en-24-formyl-28-oic acid 2 , 3 , 21 -trihydroxy-urs-12-en-28-oic acid 3 -acetyloxy-1-oxo-olean-12-en-28-oic acid 66 Berberine, palmitine, oxyacanthanine, berbamine 56 wileyonlinelibrary.com/jsfa Berberis virgetorum Jatrorrhizine, noroxyhydrastinine, (−)-berbervirine 41 Berberis tschonoskyana Oxyacantheine, obamegine, oxyberberine, obamegine, obaberine, jatrorrhirine, magnoflorine, shobakanine 69 Berberis valdiviana Thalifoline, corypalline, methylcorypalline, N-methylcorydaldine, reticuline, armepavine 55 Berberis amursensis Berbamine, hydroxy berberine, jatrorrhizine, shobakunine, berberine, ferulic acid, vanillinic acid 70 In young spears: Berberine 71 Berberis concinna In stem bark: Palmitine, berberine alkaloid 9, 9-dimetlytetracosan-6 Me(CH 2 )4COCH2CH2CMe2(CH 2 )14Me 72,73 Berberis congestiflora Patagonine, calafatine, pakistanamine, berberine 51 Berberis chitria Berberine 2 mg g −1 wileyonlinelibrary.com/jsfa Berberis umbellata 2, 5-Bis (2 ′ -methoxy-5 ′ -methylphenyl) furan (I) 102 Berberine (chloride) Tannin 30.5 mg g −1 4.7 mg g −1…”

Section: Berberis Koreanamentioning

confidence: 99%

Investigating functional properties of barberry species: an overview

Sarraf¹,

Babaei²,

Naji‐Tabasi³

2019

J Sci Food Agric

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The introduction of new crops and the development of the use of wild plants creates the potential to diversify global food production and better enable local adaptation to the diverse and changing environments that humans inhabit. Barberry is widely distributed worldwide and is recognized as a valuable plant. In this review, we summarize the functional compounds and nutraceutical features of barberry species. Barberry plants have fruits, flowers, leaves, stems and roots. All of these parts contain very important compounds, such as anthocyanins, alkaloids, flavonoids, phenolic compounds, vitamins and minerals, etc., which have been used for many years in traditional medicine. These compounds have a strong impact on human health and can be used as a painkiller, as well as for the relief of fever, diarrhea and vomiting. They are also useful for curing liver and vascular problems and preventing many diseases. One of the most important functional compounds in the barberry plant is berberine, which exists in its different parts. Studies have shown that berberine in barberry reduces cholesterol and blood glucose. It can help to prevent Alzheimer's and neoplastic diseases. Furthermore, it has antimicrobial, antifungal and antioxidant properties. According to the investigations, barberry plant derivations can be considered as useful additives and functional compounds in various industries, especially in the food industry. Ascorbic acid 149.2 mg g −1 Antioxidant activity 71.15% J Sci Food Agric 2019; 99: 5255-5269 CONCLUSIONS Barberry is a native plant in the moderate and semitropical regions, and has different types, including seeded and seedless. Previous J Sci Food Agric 2019; 99: 5255-5269

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Berberis alkaloids. XXVI. An investigation of the alkaloids ofBerberis amurensis

Cited by 10 publications

References 3 publications

μ Opioid receptor: novel antagonists and structural modeling

μ Opioid receptor: novel antagonists and structural modeling

Phytopharmacology and Clinical Updates of Berberis Species Against Diabetes and Other Metabolic Diseases

Investigating functional properties of barberry species: an overview

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