Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications

Jahan, Firdaus; Alvi, Sahir Sultan; Islam, Mohammad Hayatul

doi:10.1016/j.prmcm.2022.100184

Cited by 13 publications

(12 citation statements)

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“…An imbalanced redox state is well-reckoned to cause the establishment of distinct non-communicable ailments such as atherosclerosis [ 26 , 73 , 77 ], neuro-degeneration [ 29 ], hyperglycemia [ 30 , 78 ] and associated complications, particularly nephropathy [ 32 ]. Interestingly, the ability of robust ROS generation is thought to be the key mechanism behind the antiproliferative efficacy of the majority of the commercially available chemotherapeutic agents [ 79 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

Asif

Alvi

Azaz

et al. 2023

IJMS

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A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs) (4a–4h). Synthesized SOXs were analyzed for their drug-likeness and ADME parameters and screened for their anticancer activity. Our molecular docking analysis revealed that among all derivatives of SOXs (4a–4h), 4a has a substantial binding affinity (∆G) −6.65, −6.55, −8.73, and −7.27 Kcal/mol with CD-44, EGFR, AKR1D1, and HER-2, respectively. A functional study demonstrated that SOX 4a has a substantial impact on human cancer cell phenotypes exhibiting abnormality in cytoplasmic and nuclear architecture as well as granule formation leading to cell death. SOX 4a treatment robustly induced reactive oxygen species (ROS) generation in cancer cells as observed by enhanced DCFH-DA signals. Overall, our results suggest that SOX (4a) targets CD-44, EGFR, AKR1D1, and HER-2 and induces ROS generation in cancer cells. We conclude that SOX (4a) could be explored as a potential chemotherapeutic molecule against various cancers in appropriate pre-clinical in vitro and in vivo model systems.

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Section: Resultsmentioning

confidence: 99%

Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

Asif

Alvi

Azaz

et al. 2023

IJMS

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“…Additionally, it shows signs of possible inhibition of crucial enzymes involved in glucose metabolism, pointing to potential antidiabetic effects. In addition, Berberis exhibits antidiabetic and hepatoprotective properties by reducing liver enzyme levels, attenuating oxidative stress markers, and preventing liver cell damage (Ashrafizadeh et al 2020, Jahan et al 2022. Indigenous knowledge of various ailments remains unrecorded and lost over generations.…”

Section: Traditional Uses and Ethnopharmacologymentioning

confidence: 99%

“…(Komal et al 2011). Alkaloids, flavonoids, and berberine are some prominent compounds isolated from Berberis with sufficient antioxidant and antibacterial properties (Gaurav et al 2020, Jahan et al 2022. Jatrorrhizine, an isolated alkaloid from the plant, is used to treat gastritis and other digestive problems (Jahan et al 2022).…”

Section: Introductionmentioning

confidence: 99%

“…Alkaloids, flavonoids, and berberine are some prominent compounds isolated from Berberis with sufficient antioxidant and antibacterial properties (Gaurav et al 2020, Jahan et al 2022. Jatrorrhizine, an isolated alkaloid from the plant, is used to treat gastritis and other digestive problems (Jahan et al 2022). Other secondary metabolites, such as oxyberberine, palmatine, berberamine, karachine, palmatine chloride, tetrahydropalmatine, pseudopalmatine chloride, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Other secondary metabolites, such as oxyberberine, palmatine, berberamine, karachine, palmatine chloride, tetrahydropalmatine, pseudopalmatine chloride, etc. found in the plant can treat several ailments including diarrhea, hemorrhoids, gynecological disorders, and malarial fever (Azumder et al 2011, Chander et al 2017, Jahan et al 2022.…”

Section: Introductionmentioning

confidence: 99%

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Indigenous knowledge and bioactive compounds of Berberis aristata confirm its therapeutic potential: An ethnopharmacological appraisal in Nepal

Pandey,

Bhattarai,

Bhattarai

et al. 2023

Ethnobot. Res. App.

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Background: The prevalence of ethnomedicinal plant usage can be attributed to a combination of factors, primarily driven by local preferences towards traditional herbal remedies. This tendency is exacerbated by a dearth of practicable alternatives and the pervasiveness of economic distress. Additionally, this phenomenon is greatly influenced by a persistent belief in the effectiveness of folkloric herbal cures and the alleged medicinal qualities of local flora. Nepal stands as a region abundant in biological resources, showcasing a noteworthy reservoir of therapeutic plant species employed extensively in Ayurvedic medicine.Methods: Berberis aristata DC (also called Daruharidra / Chutro), known for its therapeutic leads, was the focus of this ethnobotanical survey, examining its chemo-diversity and medicinal properties based on its traditional use by the indigenous communities throughout Nepal. We chose to perform the qualitative phytochemical screening along with other biological analyses of B. aristata to complement and validate our findings obtained from the ethnobotanical studies.Results: Our findings revealed that 14 distinct ethnic communities residing in 24 districts utilize B. aristata for diverse therapeutic purposes, with the Tamang indigenous group being the primary users. Most ethnic communities employing B. aristata for medicinal purposes reside in the Bagmati and Koshi Provinces. Analytical chemistry revealed higher phenol and flavonoid content in Berberis leaves. The free radical scavenging assay revealed the highest values for bark methanolic extract and demonstrated strong antimicrobial properties against Staphylococcus aureus and Klebsiella pneumoniae. The inhibitory effects on α-amylase found varying levels of inhibition in different plant parts. Conclusion:Overall, the present study highlights the importance of investigating and utilizing the vast natural resources available in Nepal. Finally, we conclude traditional medicinal plants, such as B. aristata, possess enormous potential for developing novel therapeutic medications that are safe, affordable, and effective for human consumption.

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Organosulfur Compounds, S‐Allyl‐L‐Cysteine and S‐Ethyl‐L‐Cysteine, Target PCSK‐9/LDL‐R‐Axis to Ameliorate Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and High Fat Diet‐Induced Metabolic Syndrome in Rats

Ahmad,

Shah,

Waiz

et al. 2024

Phytotherapy Research

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Metabolic syndrome (MetS) is an ever‐evolving set of diseases that poses a serious health risk in many countries worldwide. Existing evidence illustrates that individuals with MetS have a 30%–40% higher chance of acquiring type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), or both. This study was undertaken to uncover the regulatory role of natural organosulfur compounds (OSCs), S‐allyl‐L‐cysteine (SAC), and S‐ethyl‐L‐cysteine (SEC), in targeting high carbohydrate high fat (HCHF)‐diet‐induced MetS‐associated risk management. Our findings suggested that SAC and SEC ameliorated HCHF‐diet‐induced diabetic profiles, plasma lipid and lipoprotein level, liver function, oxidative‐stress, inflammatory cytokines, and chemokines including monocyte chemoattractant protein‐1 (MCP‐1), lipid peroxidation, plasma proprotein convertase subtilisin/kexin type‐9 (PCSK‐9), and high‐sensitivity C‐reactive protein (hs‐CRP). Moreover, the assessment of the hepatic mRNA expression of the key genes involved in cholesterol homeostasis depicted that SAC and SEC downregulated the PCSK‐9 mRNA expression via targeting the expression of HNF‐1α, a transcriptional activator of PCSK‐9. On the other hand, the LDL‐receptor (LDL‐R) expression was upregulated through the activation of its transcriptional regulator sterol regulatory element binding protein‐2 (SREBP‐2). In addition, the activity and the mRNA expression of 3‐hydroxy‐3‐methylglutaryl coenzyme‐A reductases (HMG‐R) and peroxisome proliferator‐activated receptors (PPARs) were also improved by the treatment of SAC and SEC. We concluded that SAC and SEC can protect against MetS via improving the lipid and lipoprotein content, glycemic indices, hepatic function, targeting the inflammatory cascades, and oxidative imbalance, regulation of the mRNA expression of PCSK‐9, LDL‐R, SREBP‐2, HNF‐1α, PPARs, and inflammatory biomarkers.

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Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications

Cited by 13 publications

References 179 publications

Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

Indigenous knowledge and bioactive compounds of Berberis aristata confirm its therapeutic potential: An ethnopharmacological appraisal in Nepal

Organosulfur Compounds, S‐Allyl‐L‐Cysteine and S‐Ethyl‐L‐Cysteine, Target PCSK‐9/LDL‐R‐Axis to Ameliorate Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and High Fat Diet‐Induced Metabolic Syndrome in Rats

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