Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer

He, Xiangli; Cui, Jiayan; Ma, Hui; Abuduaini, Naijipu; Huang, Ying; Tang, Lu; Wang, Wanyan; Zhang, Yuanyuan; Wang, Yang; Lu, Weiqiang; Feng, Bo; Huang, Jin

doi:10.1016/j.bcp.2023.115868

Biochemical Pharmacology

2023

DOI: 10.1016/j.bcp.2023.115868

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Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer

Xiangli He,

Jiayan Cui,

Hui Ma

et al.

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2024

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Cited by 2 publications

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IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy

Zheng,

Li,

Guo

et al. 2024

Acta Pharmacol Sin

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IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy

Zheng,

Li,

Guo

et al. 2024

Acta Pharmacol Sin

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Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology

Li,

Sun,

Wang

et al. 2024

Front. Pharmacol.

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Chelidonium majus L. (C. majus), commonly known as “Bai Qu Cai” in China, belongs to the genus Chelidonium of the Papaveraceae family. It has rich medicinal value, such as alleviating coughs, asthma, spasms and pain. Recent studies have demonstrated that C. majus is abundant in various alkaloids, which are the primary components of C. majus and have a range of pharmacological effects, including anti-microbial, anti-inflammatory, anti-viral, and anti-tumor effects. So far, 94 alkaloids have been isolated from C. majus, including benzophenanthridine, protoberberine, aporphine, protopine and other types of alkaloids. This paper aims to review the research progress in phytochemistry, pharmacology and toxicology of C. majus alkaloids, in order to provide a theoretical basis for the application of C. majus in the field of medicinal chemistry and to afford reference for further research and development efforts.

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Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer

Cited by 2 publications

References 50 publications

IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy

IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy

Alkaloids in Chelidonium majus L: a review of its phytochemistry, pharmacology and toxicology

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