Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway

Bergenin Reduces Experimental Painful Diabetic Neuropathy by Restoring Redox and Immune Homeostasis in the Nervous System

“…The activity of Nrf2 is fundamental for the maintenance of redox homeostasis because this transcription factor modulates the levels of key redox molecules by many signaling pathways [ 40 , 41 , 43 , 44 ]. In the present work, bergenin upregulated Nrf2 mRNA in the spinal cord and DRG of mice with DN, suggesting an effective control of redox imbalance at gene level, which agrees with the results found by Qiao et al [ 26 ].…”

“…The therapeutic potential of bergenin in the treatment of diabetes had been previously suggested [ 16 , 26 , 31 ], though its effect in diabetic neuropathy had not yet been investigated. In the present study, diabetic mice treated with bergenin had a dose-dependent reduction of the behavioral signs of experimental DN.…”

“…The surplus of electrons is then transferred to oxygen molecules, generating superoxide (O 2 - ), which in turn activates damaging pathways and gives rise to other ROS in a chain reaction [ 32 ]. Previous studies have shown that bergenin diminishes intracellular levels of superoxide and other ROS by increasing the activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) [ 12 , 16 , 25 , 26 ]. In this work, the antioxidant activity of bergenin was confirmed both in vitro, by the inhibition of NO production by J774 macrophages and in vivo, by the reduction of MDA and nitrite levels in neuropathic mice’s sciatic nerve and spinal cord.…”

“…Bergenin ( Figure 1 ) is a naturally occurring C-glucoside of 4-O-methylgallic acid found in many plant species. Several therapeutic applications of bergenin have been proposed in the literature, e.g., anti-ulcerative [ 10 ], hepatoprotective [ 11 , 12 ], anticancer [ 13 ], neuroprotective [ 14 , 15 ], antidiabetic [ 16 ], anti-inflammatory [ 17 , 18 , 19 , 20 , 21 , 22 ], antinociceptive [ 17 , 23 ], and antioxidant [ 12 , 16 , 24 , 25 , 26 , 27 ]. Considering that oxidative stress and neuroinflammation play key roles in the pathophysiology of DN [ 28 ], the above-mentioned properties of bergenin may contribute to the effective control of painful DN.…”

Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway

“…Bergenin is the rare acylated iridoid glucosides extracted from some species of bergenia. It has been reported to exhibit a diversity of pharmacological properties, including anti‐inflammatory, anti‐oxidation, anti‐diabetes, and neuroprotective effects (Barai et al, 2019; Kumar et al, 2012; Lopes de Oliveira et al, 2019; Qiao et al, 2019). Recent studies indicated that bergenin exhibited significant pharmacological activities such as anticancer (Shi et al, 2019).…”