Bergenin is the Antiarrhythmic Principle of Fluggea virosa

Abstract

Bergenin was isolated from the aerial parts of Fluggea virosa (Euphorbiaceae). Its structure was elucidated on the basis of chemical and spectral data. Anti-arrhythmic effects of bergenin were investigated. At concentrations of 0.2 mg/kg, 0.4 mg/kg, and 0.8 mg/kg, bergenin showed distinct therapeutic effects on BaCl2-induced arrhythmias in rats. At concentrations of 0.4 mg/kg and 0.8 mg/kg bergenin significantly countered arrhythmias induced by ligation and reperfusion of the coronary artery. At 0.8 mg/kg, bergenin elevated the atria fibrillation threshold in rabbits from 1.34 mV to 1.92 mV. Our results suggest that bergenin has good potential to treat cardiac arrhythmias.

The Hidden Treasure in Europe?s Garden Plants: Case Examples; Berberis darwinni and Berginia cordifolia

“…The most notable biological activity of arbutin is potent inhibition of tyrosinase enzyme that attribuites to its use as a commercial skin lightning agent [74][75][76]. On the other hand, bergenin has numerous biological effects, including antiviral [77], antiulcer [78], antiarethmetic [79], antidiabetic and anti-obesity [80], anti-inflammatory [81], immunomodulatory [82] and hepatoprotective [83][84][85] effects.…”

Effect of Bergenin on the Kidney of C57BL/6J Mice with High Fat-Diet Induced Oxidative Stress

“…It is dihydroisocoumarin derivative isolated from several medicinal plants such as Ficuus racemosa [7], Mallotus japonicas [8], Bergenia crassifolia, Caesalpinia digyna, Astibe thunbergii, Ardisia japonica plant and also other genera [9]. Bergenin contains five hydroxyl groups which are consider to be potentially active and it exhibit various biological activities such as antioxidant [10], hepatoprotective [11], antiarrhythmic [12], antimicrobial, antiviral and antiulcerogenic activities [13], anti-inflammatory [14]. Bergenin is reported as insulin sensitisers [7] and has potential antidiabetic effect [15].…”

Isolation and antimicrobial efficacy tests of Bergenia ciliate using in vitro models

“…Bergenin is reported to have anti-inflammatory (Swarnalakshmi et al, 1984), hypolipidaemic (Jahromi et al., 1992), anti-HIV (Piacente et al, 1996), antiarrhythmic (Pu et al, 2002), hepatoprotective , neuroprotective (Takahashi et al, 2003) and gastroprotective (Goel et al, 1997) activities. Its Odemethylated derivative, that is, norbergenin (compound 2) has been shown to have antioxidant (Takahashi et al, 2003) and gastroprotective (Goel et al, 1997) activities.…”