Berger disease: thirty years later

Davin, Jean–Claude; Weening, Jan J.

doi:10.1007/s004310051115

Cited by 15 publications

(11 citation statements)

References 60 publications

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“…Frequent tonsillitis during the preceding year was also related to a much increased risk. These findings will clearly support the hypothesis that bacterial or viral infections in the upper respiratory tract are involved in the development of IgAN [2, 3, 4]. IgA provides a primary defense mechanism against some local infections in mucosa, and IgA resulting from an immune response to the pathogens would play a role in the nephropathy.…”

Section: Discussionsupporting

confidence: 64%

“…This provided further evidence for the significance of genetic backgrounds in this disease [3, 4]. Scolari et al [22]reported that 14% of the patients with IgAN had a family history of this nephropathy.…”

Section: Discussionmentioning

confidence: 97%

“…Although experimental and clinical studies have shown the contribution of several genetic and environmental factors to the disease [2, 3, 4], no risk factor except for exposure to organic solvents [6, 7]was found by previous epidemiological investigations. We therefore performed a case-control study of IgAN in 1997 and found several potential risk or protective factors [8].…”

Section: Introductionmentioning

confidence: 99%

“…Immunoglobulin A nephropathy (IgAN) is one of the most common types of glomerulonephritis in the world [1, 2, 3, 4]. This nephropathy is now regarded as an important health issue because 10–50% of the patients will develop end-stage renal disease within two decades [3, 4].…”

Section: Introductionmentioning

confidence: 99%

“…This nephropathy is now regarded as an important health issue because 10–50% of the patients will develop end-stage renal disease within two decades [3, 4]. In Japan, we estimated the numer of patients treated for histologically confirmed IgAN in 1994 as 24,000 (95% confidence interval, CI, 21,000–27,000) [5].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Risk Factors for IgA Nephropathy: A Case-Control Study with Incident Cases in Japan

Wakai¹,

Nakai²,

Matsuo³

et al. 2001

Nephron

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Background/Aim: Our previous study with prevalent cases suggested that some genetic, immunological and lifestyle-related factors increased the risk of immunoglobulin A nephropathy (IgAN). To confirm this hypothesis, we conducted another case-control study. Methods: The study included 116 incident cases and 276 sex-, age- and residence-matched controls in central Japan. Information on family and individual history and on lifestyle was collected using a self-administered questionnaire. The strength of association between IgAN and a potential risk factor was assessed by calculating an odds ratio. Results: A family history of chronic glomerulonephritis, susceptibility to the common cold, episodes of tonsillitis in the preceding year, preference for salty foods and a high intake of rice and n–6 polyunsaturated fatty acids (PUFA) were associated with an increased risk of IgAN. Coffee consumption and dietary calcium intake were somewhat negatively related to the risk. A significance of alcohol drinking, use of vitamin supplements, consumption of raw eggs and intake of nutrients other than n–6 PUFA and calcium, though previously suggested, was not shown in the present study. Conclusion: Our findings imply that some genetic factors, immune response to infections in the upper respiratory tract and nutritional imbalance would promote the development of IgAN.

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Section: Discussionsupporting

confidence: 64%