Berlin Initiative Study 1 equation and HUGE formula for more accurate estimation of kidney function in elderly

Matašin, Marija; Domislović, Viktor; Fuček, Mirjana; Gellineo, Lana; Jelaković, Ana; Dika, Živka; Jelaković, Bojan

doi:10.21857/ydkx2cw8k9

Cited by 2 publications

(1 citation statement)

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“…A suggested method to overcome false positives would be to use the third percentile of eGFR creatinine levels and age-calibrated thresholds [ 26 ]. Alternatively, the Berlin Initiative Study 1 equation would be more suitable for subjects older than 70 years [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

The prevalence of chronic kidney disease in South Africa - limitations of studies comparing prevalence with sub-Saharan Africa, Africa, and globally

et al. 2023

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Background Chronic kidney disease (CKD) is a globally significant non-communicable disorder. CKD prevalence varies between countries and within a country. We compared the prevalence rates of CKD in South Africa with sub-Saharan Africa, Africa, and globally. Methods We registered a systematic review with the International Prospective Register of Systematic Reviews for prevalence studies reporting CKD stages III-V from 2013 to 2021. The analysis sought to explain any significant differences in prevalence rates. The R statistical package was used for data analysis. Comparisons included measures of effect size due to the large sample sizes analysed. We also compared sex differences in prevalence rates, common aetiologies, and type of study methodologies employed. Results Eight studies were analysed, with two from each region. The matched prevalence rates of CKD between the various regions and South Africa showed significant differences, except for one comparison between South Africa and an African study [p = 0.09 (95% CI − 0.04–0.01)]. Both sub-Saharan African studies had a higher prevalence than South Africa. One study in Africa had a higher prevalence, while the other had a lower prevalence, whilst one Global study had a higher prevalence, and the other had a lower prevalence compared to South Africa. The statistical differences analysed using the Cramer’s V test were substantially less than 0.1. Thus, differences in comparisons were largely due to differences in sample sizes rather than actual differences. Conclusion Variable prevalence rates between regions included disparities in sample size, definitions of CKD, lack of chronicity testing and heterogeneous laboratory estimations of eGFR. Improved consistency and enhanced methods for diagnosing and comparing CKD prevalence are essential.

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Section: Discussionmentioning

confidence: 99%

The prevalence of chronic kidney disease in South Africa - limitations of studies comparing prevalence with sub-Saharan Africa, Africa, and globally

et al. 2023

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Can different formulae be used in the diagnosis and staging of chronic kidney disease?

Çam,

Kural,

Yılmaz

2024

Turkish Journal of Biochemistry

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Objectives Chronic kidney disease (CKD), which has a significant prevalence of 15.7 % in Turkey, is a global health problem that particularly affects elderly. It is difficult to distinguish between age-related and CKD-related declines in kidney function with current glomerular filtration rate (GFR) estimation methods. The “HUGE” formula, incorporating haematocrit, urea, and gender, offers improved differentiation, targeting individuals over 40. This study aims to evaluate the effectiveness of the HUGE formula in estimating GFR in this demographic group and to establish a better diagnostic threshold. Methods A retrospective study of 500 participants over 40 years was conducted and divided into CKD (252) and non-CKD (248) based on demographics, laboratory tests and ultrasound evaluation. Renal function was classified by the HUGE equation (HUGE<0 for age-related decline; ≥ 0 for CKD) and GFR estimates were compared with KDIGO guidelines via CKD-EPI, FAS and BIS1. Results We observed significant discrepancies in estimated glomerular filtration rate (eGFR) and its staging among different formulas. The HUGE formula showed better agreement with eGFR staging after the cut-off point was set as “−1.58” and improved diagnostic accuracy, especially in stages 3a and 3b. Conclusions The study validates the HUGE formula improved accuracy in diagnosing CKD, especially for stages 3a and 3b, with a new cut-off value of “−1.58”. It supports the inclusion of the HUGE formula into current diagnostic practices to improve the identification and staging of CKD in individuals over the age of 40, while also demonstrating the necessity for further clinical evaluations.

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Berlin Initiative Study 1 equation and HUGE formula for more accurate estimation of kidney function in elderly

Cited by 2 publications

References 23 publications

The prevalence of chronic kidney disease in South Africa - limitations of studies comparing prevalence with sub-Saharan Africa, Africa, and globally

The prevalence of chronic kidney disease in South Africa - limitations of studies comparing prevalence with sub-Saharan Africa, Africa, and globally

Can different formulae be used in the diagnosis and staging of chronic kidney disease?

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