Search citation statements
Paper Sections
Citation Types
Year Published
Publication Types
Relationship
Authors
Journals
Wound dressings developed by combining plant extracts with polymers have made a great progress in wound care treatment. One plant with remarkable healing properties is Phyllanthus emblica Linn (P. emblica), which is described as having potent antioxidant, antimicrobial and anti‐inflammatory properties. The aim of this study is to evaluate the biocompatibility of P. emblica‐loaded polyvinyl alcohol/gelatin‐based cryogels (PVA/Gel/P.emblica) through cytotoxicity and proliferation tests in HaCaT cells and examine their potential in wound dressing applications. Accordingly, PVA/Gel/P.emblica cryogels are successfully synthesized and characterization studies and in vitro cell culture studies are performed. The swelling tests and Brunauer–Emmett–Teller analysis results show that swelling and surface area properties of cryogels increase with increasing P. emblica amounts. Morphological results display that the cryogels have a dense, interconnected pore morphology and a macroporous structure. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, trypan blue exclusion, and live–dead assay results reveal that P. emblica enhances cell proliferation, increases cell number, and improves cell viability. Based on the scanning electron microscope, immunofluorescence, and Giemsa staining images, it is observed that P. emblica promotes cell attachment, proliferation, and penetration. These findings confirm that PVA/Gel/P.emblica cryogels are suitable for use as wound dressing materials and can be developed with further studies.
Wound dressings developed by combining plant extracts with polymers have made a great progress in wound care treatment. One plant with remarkable healing properties is Phyllanthus emblica Linn (P. emblica), which is described as having potent antioxidant, antimicrobial and anti‐inflammatory properties. The aim of this study is to evaluate the biocompatibility of P. emblica‐loaded polyvinyl alcohol/gelatin‐based cryogels (PVA/Gel/P.emblica) through cytotoxicity and proliferation tests in HaCaT cells and examine their potential in wound dressing applications. Accordingly, PVA/Gel/P.emblica cryogels are successfully synthesized and characterization studies and in vitro cell culture studies are performed. The swelling tests and Brunauer–Emmett–Teller analysis results show that swelling and surface area properties of cryogels increase with increasing P. emblica amounts. Morphological results display that the cryogels have a dense, interconnected pore morphology and a macroporous structure. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide, trypan blue exclusion, and live–dead assay results reveal that P. emblica enhances cell proliferation, increases cell number, and improves cell viability. Based on the scanning electron microscope, immunofluorescence, and Giemsa staining images, it is observed that P. emblica promotes cell attachment, proliferation, and penetration. These findings confirm that PVA/Gel/P.emblica cryogels are suitable for use as wound dressing materials and can be developed with further studies.
Background Rubus glaucus Benth, called Andean blackberry, is a species of significant economic and ecological importance. Despite its relevance, scientific research on this plant remains fragmented and scattered across disciplines. Objective This study aims to systematically assess the state of scientific knowledge on R. glaucus, identifying research trends, collaborations, and thematic evolutions within the global research community. Methods We employed a comprehensive bibliometric analysis integrated with Latent Dirichlet Allocation (LDA) and HJ-Biplot methodologies to analyze publications from Scopus and Web of Science databases. Results Our findings reveal a substantial increase in research interest from the 1990s, reaching a peak in the early 2010s before a recent decline. The study highlights significant contributions from the United States, the United Kingdom, Canada, Italy, and Colombia, with notable international collaborations. Thematic analysis underscored the ecological role, nutritional benefits, and genetic improvement of R. glaucus as focal areas of research, pointing out gaps in pest management and sustainable cultivation practices. Conclusions This comprehensive bibliometric analysis offers valuable insights into the research landscape of R. glaucus, underscoring the need for focused research efforts on underexplored areas. The study lays the groundwork for future research directions, encouraging interdisciplinary collaboration to leverage the plant's full potential for agricultural innovation.
Menopause is a critical stage in a woman’s life in which cardiometabolic alterations appear, such as insulin resistance or a predisposition to visceral fat deposits, leading to an increased risk of cardiometabolic diseases (R-CMBs). New strategies to reduce the R-CMBs in postmenopausal women using natural compounds without adverse effects are desirable. In this sense, plant-based diets rich in fruits and vegetables could play a fundamental role due to the high content of bioactive compounds found in these diets, such as (poly)phenols, known for their antioxidant, anti-inflammatory and vasodilator properties. The aim of this research was to carry out a dietary trial to evaluate the effect of the daily intake of different (poly)phenol-rich foods (PP-rich foods) for 2 months on the modulation of the main cardiometabolic risk biomarkers of postmenopausal women. The results showed a slight improvement in blood pressure (BP), lipid profile and oxidative stress, endothelial function and inflammatory biomarkers. These findings suggest that daily consumption of PP-rich foods alleviated the R-CMBs of postmenopausal women by reducing the oxidative stress and, thus, the risk of cardiovascular events; however, the magnitude of the cardioprotective effect of (poly)phenols depends on inter-individual variability.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.