Berries grown in Brazil: anthocyanin profiles and biological properties

Chaves, Vítor Clasen; Boff, Laurita; Vizzotto, M.; Calvete, Eunice Oliveira; Reginatto, Flávio Henrique; Simões, C. M. O.

doi:10.1002/jsfa.8959

Cited by 47 publications

(25 citation statements)

References 40 publications

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“…Cyanidin is an anthocyanin that has been extensively studied due to its antioxidant protection through the modulation of the Nrf2 transcription factor [ 23 ]. Although the berry production is more common in the Northern Hemisphere, the chromatographic profile observed in this study is in agreement with other studies of berries grown in Brazil [ 24 ].…”

Section: Discussionsupporting

confidence: 92%

Anti‐Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS‐Induced Sepsis

Lúcio

Rabêlo

Araújo

et al. 2018

Oxidative Medicine and Cellular Longevity

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Sepsis is a complex disease and is the cause of many deaths worldwide. Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species. The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution. Thus, more studies have been carried out to investigate the therapeutic potential of plants such as Morus nigra L., popularly known as black mulberry. Studies have shown that plants belonging to the Morus genus are rich in secondary metabolites such as flavonoids which are associated with important biological activities as antioxidant and anti-inflammatory actions. Based on this context, the objective of our study was to evaluate the anti-inflammatory and antioxidant properties of Morus nigra L. in a sepsis model induced by LPS. Male C57BL/6 mice were distributed in four groups: control, sepsis, sepsis treated with leaf extract of mulberry, and sepsis treated with mulberry pulp. The animals were treated with 100 μL of their respective treatments for twenty-one days. Sepsis was induced at the 21st day with lipopolysaccharide (LPS) by intraperitoneal injection. The animals were euthanized 24 hours after receiving the LPS injection. The data obtained were analyzed in GraphPad Prism 6.0 software. Our results showed that treatment with either extract significantly decreased the number of leukocytes in the bronchoalveolar lavage fluid and serum levels of TNF in septic animals. Regarding the redox status, the treatments significantly decreased the antioxidant activity of the enzyme glutathione peroxidase. Regarding metalloproteinase type 2, it was observed that the treatment with black mulberry pulp was able to significantly reduce the activity of this enzyme concerning the sepsis group. Finally, these results together promoted an increase in the animal's survival that received the black mulberry leaf or pulp extract.

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Section: Discussionsupporting

confidence: 92%

Anti‐Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS‐Induced Sepsis

Lúcio

Rabêlo

Araújo

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Secondary metabolites have important defence and signalling roles, and they contribute a lot to the quality of fruits. The phenolic compounds, including flavonoids (anthocyanins, flavonols, flavones, flavanols, flavanones and isoflavonoids), stilbenes, tannins and phenolic acids, are the main secondary metabolites in berries. Phenolics are natural antimicrobial substances .…”

Section: Introductionmentioning

confidence: 99%

Comparative assessment of chemical compositions, antioxidant and antimicrobial activity in ten berries grown in China

Liang

Xin

2019

Flavour & Fragrance J

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Berries have many biological and physiological functions such as antioxidant, antibacterial and anti-inflammatory, and become a more popular food in China. Water-soluble polyphenols are their main functional active substances, and aroma components contribute to the flavour. The contents of total phenol and volatile organic compounds (VOCs) in ten berries grown in Northeast China were determined. Their antioxidant and antimicrobial activities were also investigated. Ribes rubrum L. and Rubus glaucus showed a higher antioxidant capacity. Ribes rubrum L. and Lonicera caerulea have a broader antibacterial spectrum. There is a correlation between the content of hydroxyl compounds in radical antioxidant activity. The metabolic pathways of polyphenols and VOCs are correlated, indicating a rapid evaluation of the biological activity of berries using the determination of volatile components. K E Y W O R D Sberries, VOCs, antioxidant, antimicrobial activity, correlation analysis

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“…Specially, the consumption of berries is recommended due to their antioxidant properties [1]. Berries, in botanical terms, are defined as fleshy fruits that emerge from the plant ovary that encloses the seeds; due to this, berries include grapes, blueberries, black currants, and coffee beans [9].…”

Section: Berriesmentioning

confidence: 99%

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

Fernández-Demeneghi¹,

Isidro²,

Acosta-Mesa³

et al. 2020

Behavioral Pharmacology - From Basic to Clinical Research

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This chapter is based in the compilation and analysis of different in vitro, preclinical, and clinical studies, which explored the potential beneficial bioactivity of supplementation with berries on some alterations in the central nervous system (CNS). The last section of the chapter describes the possible mechanisms of action of polyphenols, anthocyanins, and other compounds present in berries as well as their relationship with anxiety, depression, and Alzheimer's (AD) and Parkinson's diseases (PD) and their implication in the prevention of cognitive decline and senescence motor functions. Electronic databases as Springer, PubMed, Scopus, and Elsevier were used. Papers were selected by topic specially those related with berries, year of publication, and authors. The present chapter evidenced the potential health effect as neuroprotector of different berries and their bioactive compounds mainly flavonoids, polyphenols, and anthocyanins, on diseases such as anxiety, depression, and Alzheimer's and Parkinson's diseases. In conclusion, for human nutrition berry fruit supplementation might be an excellent source of antioxidant and alternative for prevention and reduction of symptoms in diseases such as anxiety, depression, Alzheimer's, and Parkinson's.

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Berries grown in Brazil: anthocyanin profiles and biological properties

Abstract: Total anthocyanin content of all fruits had a strong positive correlation with their free radical scavenging activity, suggesting anthocyanins contribute to the antioxidant potential of these fruits. © 2018 Society of Chemical Industry.

Cited by 47 publications

References 40 publications

Anti‐Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS‐Induced Sepsis

Anti‐Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS‐Induced Sepsis

Comparative assessment of chemical compositions, antioxidant and antimicrobial activity in ten berries grown in China

Berry Supplementation and Their Beneficial Effects on Some Central Nervous System Disorders

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