Berries in the Prevention of Esophageal Adenocarcinoma

Kresty, Laura A.; Exum, Amy; Zeyzus-Johns, Bree

doi:10.1007/978-1-4419-7554-6_5

Cited by 4 publications

(10 citation statements)

References 74 publications

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“…We found that C‐PACs had potent cell death–inducing capacity against esophageal, lung, and colon cancer cells, at much lower concentrations compared to strawberry or black raspberry constituents. Thus, we embarked on a series of preclinical studies to evaluate mechanisms associated with the cancer inhibitory potential of C‐PAC, using a panel of human EAC cell lines (JHAD1, OE33, OE19) and, in parallel, assessing inhibition of OE19 tumor xenografts in athymic NU/NU mice . Our results show that C‐PAC significantly induces EAC cell death via apoptosis, autophagy, and necrosis.…”

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 93%

“…Neto reviewed cancer‐linked cranberry research conducted through early 2011 (Table ). The vast majority of research assessing cranberries as cancer inhibitors has been conducted in vitro , utilizing a number of cranberry extracts and diverse human cancer cell lines (Table ), including our research focused on EAC inhibition. Briefly, intraperitoneal injection of cranberry extracts, especially the C‐PAC fraction, increases tumor latency and inhibits growth of gastric, colon, prostate, lymphoma, and glioblastoma cancer cells, supporting in vivo efficacy of C‐PACs when administered directly.…”

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 99%

“…Cell death induction by C‐PAC was caspase independent but linked to proapoptotic protein activation (BAX, BAK1, cytochrome C, PARP), cell line–selective MAPK (P‐p38/P‐ERK/P‐JNK) modulation, and cell line–specific reactive oxygen species (ROS) effects. C‐PAC maximally induces ROS levels in JHAD1 and OE33 cells, resulting in cell death via apoptosis and autophagy; yet C‐PAC modestly increases ROS levels in OE19 cells, resulting in necrotic cell death …”

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 99%

“…Table summarizes cancer‐linked signaling networks modulated by cranberry constituents on the basis of our research and the published literature . In addition, we evaluated C‐PAC modulation of microRNAs.…”

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 99%

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Upper esophageal and pharyngeal cancers

Bock

Howell

Johnston

et al. 2014

Annals of the New York Academy of Sciences

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The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on laryngopharyngeal reflux as a risk factor for laryngeal cancer; the role of pepsin in laryngopharyngeal neoplasia; natural fruit and vegetable compounds for the prevention and treatment of pharyngeal and esophageal cancers; and evaluation of cranberry constituents as inhibitors of esophageal adenocarcinoma utilizing in vitro assay and in vivo models.

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Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 93%

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 99%

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 99%

Section: Cranberries Hold Cancer Inhibitory Potential For Targeting Eacmentioning

confidence: 99%

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Upper esophageal and pharyngeal cancers

Bock

Howell

Johnston

et al. 2014

Annals of the New York Academy of Sciences

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“…While the rate of squamous cell carcinoma (the most common histological subtype worldwide) is decreasing in the West, adenocarcinoma is becoming increasingly prevalent in northern Europe and North America (5)(6)(7)(8). Esophageal adenocarcinoma (EA) has the fastest increasing incidence of all malignancies in the United States, with a growth rate of over 500% in the past 30 years (5,9).…”

Section: Introductionmentioning

confidence: 99%

CT-based assessment of visceral adiposity and outcomes for esophageal adenocarcinoma

Saeed¹,

Shridhar²,

Almhanna³

et al. 2017

J. Gastrointest. Oncol.

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Background: Various methods of quantifying and correlating obesity to outcomes for patients with esophageal adenocarcinoma (EA) have been evaluated. Published data suggest that quantification of adiposity may be more accurate than body mass index (BMI) as a prognostic factor. We report our analysis of adiposity as a prognostic factor in a series of patients with EA. to −130. Outcomes were analyzed using Kaplan-Meier method and log-rank analysis. Multivariate analysis (MVA) was performed using the Cox proportion hazard regression model. Results:We identified 126 patients for the analysis. There were no statistically significant differences in overall survival or disease-free survival between groups above and below the medians for TFA, SFA, or VFA/SFA ratio. However, an increase in VFA was significantly associated with worsened OS and DFS when we further classified patients into quartiles. Patients with VFA ≥182 cm² had larger tumor size (P=0.016), fewer involved lymph nodes (P=0.047), longer operating times (P=0.032), and were more likely to be males (P=0.042).Conclusions: Published data have demonstrated an association between treatment outcomes and degree of adiposity; our study found a correlation between VFA and OS and DFS in patients with EA. Median TFA, SFA, and VFA/SFA were not prognostic on MVA. While VFA >182 cm 2 was associated with larger tumors, there were also fewer lymph nodes harvested in this group.

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Recent advances in esophageal squamous cell precancerous conditions: A review

2022

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Esophageal squamous cell carcinoma (ESCC) is a common cancer in many developing countries in Asia and Africa, with a 5-year survival rate of approximately 20%. Most cases are diagnosed at an advanced age when there is no effective treatment strategy. Esophageal precancerous conditions have a much better prognosis, with a 5-year survival rate of over 90% by endoscopic diagnosis and treatment. Nevertheless, limitations, contraindications, and lymph node metastasis incompetency of endoscopy. Thus, the diagnosis and treatment of esophageal precancerous lesions remain a significant challenge. Biomarker investigations provide opportunities for target detection and therapy. Additionally, drug development is ongoing. Changes in lifestyle habits, such as diet balance, smoking and alcohol cessation, are beneficial for the prognosis of esophageal precancerous lesions. Collectively, multiple and sequential diagnoses and treatments are essential for curing esophageal precancerous lesions and reducing the incidence and mortality of ESCC.Abbreviations: CIS = carcinoma in situ, Egr-1 = early growth response gene-1, ESCC = esophageal squamous cell cancer, FHIT = fragile histidine triad, HE = Hematoxylin-Eosin, HGF = hepatocyte growth factor, HGIN = high-grade intraepithelial neoplasia, IMP1 = insulin-like growth factor II mRNA-binding protein 1, LGIN = low-grade intraepithelial neoplasia, MTHFR = 677T methylenetetrahydrofolate reductase, PAX9 = paired box 9, PHCA = plant-associated human cancer antigen, SCCAs = squamous cell carcinoma antigens, USP9X = ubiquitin-specific peptidase 9, USPs = ubiquitin-specific peptidases.

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Berries in the Prevention of Esophageal Adenocarcinoma

Cited by 4 publications

References 74 publications

Upper esophageal and pharyngeal cancers

Upper esophageal and pharyngeal cancers

CT-based assessment of visceral adiposity and outcomes for esophageal adenocarcinoma

Recent advances in esophageal squamous cell precancerous conditions: A review

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