Besinlerle Yapılan Atopi Yama Testinin SCORAD İle İlişkisi

Abstract

Türk derm-De ri Has ta lık la rı ve Fren gi Ar şi vi Der gi si, Ga le nos Ya yı ne vi ta ra f›n dan ba s›l m›fl t›r. Turk derm-Arc hi ves of the Tur kish Der ma to logy and Ve ne ro logy, pub lis hed by Ga le nos Pub lis hing. ÖzetAmaç: Besinlerle atopik dermatit (AD) kliniği arasındaki ilişki tartışmalıdır.Besinlerle yapılan "fresh prick testleri"nin (FPT) özgünlüğünün düşük olması, AD'de çoğunlukla lezyonların geç ortaya çıkması ve buna bağlı anamnezdeki tutarsızlıklar, provokasyon testinin zaman alıcı ve riskli olması, hastalığın fizyopatolojisinde T lenfositlerin oynamış olduğu rol, atopi yama testini (APT: "Atopy Patch Test") ön plana çıkartmaktadır. Bu çalışmada besinlerle yapılan APT ve FPT'nin hastalığın ağırlığını yansıtan SCORAD indeksi ile olan ilişkisi araştırılmıştır. Sum maryBackground and Design: The relationship between food and atopic dermatitis (AD) is controversial. Atopy patch test (APT) gained prominence due to low specificity of "fresh prick tests" (FPT) with foods, commonly late occurrence of lesions in AD and, thus, the inconsistencies in anamneses, and being the provocative tests time consuming and risky, as well as due to the role of T lymphocytes in the pathophysiology of the disease. In this study, we investigated the relationship of APT and FPT made with food with SCORAD index assessing the disease severity. Materials and Methods: Forty-five children (21 males and 24 females) aged between 2-15 years who were diagnosed with AD in our outpatient clinic between May 2006 and May 2007 were included in the study. FPT and APT with eggs, milk and wheat flour were performed in all patients. The severity of illness was assessed using the SCORAD index. Statistical analysis was performed using SPSS version 11.0 for Windows. A p value of less than 0.05 was considered statistically significant.

Food Allergy and Philagrine Mutation in Children with Atopic Dermatitis

“…In this study, no relation was observed between SCORAD index and prick test positivity, total IgE, and serum eosinophil count. 16 These results were similar to our results. In a study in which 236 patients with AD were examined, food allergen sensitization was positive in 31% of patients, and the most common food allergies were found against egg, cow's milk, and peanuts.…”

“…• No significant correlation was found between the severity of AD and food allergy and laboratory tests. Severe AD was found to be 24.2% (16). In our study, the rate of FLG mutations was found to be 1.51%.…”

The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

“…Aeroallergens are also one of the AD triggers and include indoor aeroallergens such as house dust mite (HDM), pet dander, fur, cockroach, and mold, and outdoor aeroallergens such as tree, grass, and weed pollen (Werfel et al, 2015;Chong et al, 2022). HDM is a common sensitizing factor in pediatric AD patients and it has been also reported that children with a strong skin prick test reaction to HDM have more severe disease (Kutlu et al, 2013).…”