Bespreking van Groot, P. J. M. (1973) <i>Het toetsen van taalvaardigheid</i>

Goethals, M.

doi:10.1075/itl.20.08goe

Cited by 2 publications

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“…7 TdR has also been labeled with 11 C for imaging studies using PET, and most of the efforts to develop a radiotracer for imaging DNA synthesis have focused on TdR. [8][9][10][11][12][13][14][15][16][17][18] However, the use of radiolabeled TdR in PET imaging has been limited because it is catabolized in vivo by TdR phosphorylase (TPase) 19 and then degraded by other enzymes. 20 Several analogs of TdR have been radiolabeled with PET isotopes for imaging of tumor proliferation and herpes simplex virus TdR kinase (HSV1-tk) gene expression.…”

Section: Introductionmentioning

confidence: 99%

“…Extensive in vivo studies have been performed using [ 11 C] TdR 11,12,17,19,[35][36][37][38][39] for PET imaging of tumor proliferation and DNA synthesis. 37 However, the rapid in vivo catabolism of [ 11 C] TdR limits its application in PET imaging.…”

Section: Introductionmentioning

confidence: 99%

“…37 However, the rapid in vivo catabolism of [ 11 C] TdR limits its application in PET imaging. 17,19,37,38 [ 11 C]-TdR is catabolized by TPase and then other enzymes to produce CO 2 , NH 3 , and b-aminoisobutyric acid (b-AIB). About 80% of the circulating activity was found to be [ 11 C]b-AIB 10 min after injection of [ 11 C-methyl]TdR.…”

Section: Introductionmentioning

confidence: 99%

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Nucleoside‐based probes for imaging tumor proliferation using positron emission tomography

Alauddin

2013

Labelled Comp Radiopharmac

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Cancer is one of the leading causes of human death, and early detection can be beneficial for its timely therapy and management. For the early detection of cancer, positron emission tomography (PET) is more accurate and sensitive than other imaging modalities, such as computed tomography and magnetic resonance imaging. [(18) F]-Labeled fluorodeoxyglucose is the most useful PET probe in early detection of cancer; however, its nonspecific accumulation and consequent false-positive findings warrant the identification of other PET probes. Thymidine (TdR) and its analogs have been radiolabeled for PET imaging of cellular proliferation and DNA synthesis. Because of its in vivo instability, radiolabeled TdR has not been successful in PET imaging. However, some of its radiolabeled analogs have been developed for PET imaging of cellular proliferation and DNA synthesis. In this review, the radiochemistry and production of (11) C-TdR and (11) C/(18) F-labeled TdR analogs published to date are presented.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nucleoside‐based probes for imaging tumor proliferation using positron emission tomography

Alauddin

2013

Labelled Comp Radiopharmac

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“…The clinical use of nucleic acid ligands such as ["Clthymidine has been restricted however, by the rapid in vivo breakdown of this compound and therefore the rapid appearance of radioactive metabolites (1). This situation limits contrast between proliferating and non-proliferating tissues in images and complicates modeling (2). These criteria have encouraged us to search for a more stable thymidine analogue that would be suitable for radiolabelling with [''a.…”

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confidence: 99%