Besseres Darstellungsverfahren für Mononatrium‐cyanamid

Weiß, Stefan; Krommer, Helmut

doi:10.1002/ange.19740861608

Cited by 13 publications

(13 citation statements)

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“…In a small volume pressure reactor were placed 20 milli-equiv. of a polyprimary amine (free base or hydrochloride salt), 3.08 g of 0-methylisouronium sulfate [23] and 10 ml of conc.…”

Section: Experimental Partmentioning

confidence: 99%

Anion Coordination Chemistry: Polyguanidinium Salts as Anion Complexones

Dietrich¹,

Fyles²,

Fyles³

et al. 1979

Helvetica Chimica Acta

181

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SummaryThe synthesis of a series of polyguanidinium salts of potential interest as anion complexones is described. Among the various synthetic methods investigated, the polyguanidinium salts were found to be most conveniently prepared from polyamines via polypitroguanidine intermediates. The complexation of phosphate and carboxylate anions by these complexones and by related polyammonium salts were studied by analysis of pH-metric titration data. The ligands studied form relatively stable complexes (log K,= 2.0-4.0 for PO:-in water) which also present good selectivities in some cases. Both the stability and the selectivity of complexation are primarily governed by electrostatic forces and thus depend on charge accumulation in the interacting species; structural effects are also observed. Since the binding is primarily electrostatic, polyammonium salts form more stable complexes (at a given charge) than do polyguanidinium salts. However, whereas the complexation properties of the latter are independent of pH, the complexes of the former are observed only in the limited ranges of pH where both the protonated polyamine and the anion of interest can coexist. The polycationic ligands may, in principle, form chelate type anion complexes. Comparison with the corresponding single binding sites reveals an increase in complexation constant of about two or three orders of magnitude; this may be considered as a thermodynamic indication of a chelate effect for the polydentate ligands (by analogy with the well known effects displayed by cation complexones); however, structural data on the formation of chelate 'rings' are not yet available. The nature of the complexes and the prospects of anion complexones in various fields are discussed.

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“…In a small volume pressure reactor were placed 20 milli-equiv. of a polyprimary amine (free base or hydrochloride salt), 3.08 g of 0-methylisouronium sulfate [23] and 10 ml of conc.…”

Section: Experimental Partmentioning

confidence: 99%

Anion Coordination Chemistry: Polyguanidinium Salts as Anion Complexones

Dietrich¹,

Fyles²,

Fyles³

et al. 1979

Helvetica Chimica Acta

181

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“…[12] 5-Bromosalicylaldehyde and sodium 5,5-diethylbarbiturate were purchased and used without further purification.…”

Section: Methodsmentioning

confidence: 99%

A New Ligand for the Formation of Triangular Building Blocks in Supramolecular Chemistry

Müller

Möller

2005

Eur J Inorg Chem

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In this article we describe the synthesis, characterisation and metal binding properties of tris(5-bromo-2-hydroxybenzylidene)triaminoguanidinium chloride [H 6 Br 3 L]Cl (1), which can be seen as a triangular building block for supramolecular chemistry. 1 crystallises either in a triclinic (1a) or a rhombohedral (1b) system depending on the used solvent . The pure ligand adopts a conformation unfavourable for the coordination of metal centres, but in the presence of a base or a basic metal salt, a change in the conformation can be observed.

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“…In this context, very few dimethoxytriazines have been described [24][25][26][27][28][29][30][31][32][33][34], and some of their 2-(alk-1 0 -ynyl) derivatives such as I-III [35] present interesting cytotoxic activities toward different tumor cell lines (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

“…The method utilized for the synthesis of these acetylenic compounds is the palladium catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dimethoxy-1,3,5-triazine [36][37][38]. As for their 2-alkyl analogs, they were often obtained by reacting zinc bis(imino-bismethyl carbamate) 3 with acid chloride or anhydride [25,26,33,34], and we have reported that 4 Å molecular sieves and pyridine can be advantageously utilized in this reaction [39,40]. The molecular structure of zinc salt was initially described as 3a [24], but we recently proved from an RX study (see 'Supporting information' section) that the real structure was 3b, 1 as suggested in a patent [25,26], but not confirmed (Fig.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological evaluation of a new class of triazin–triazoles as potential inhibitors of human farnesyltransferase

et al. 2015

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A new synthesis of ethynyldimethoxytriazine 1, an important platformcompound for developing new chemical entities for anticancer research and for other biological applications, is described. Compound 1 was further reacted with azides 5a-i to provide triazin-triazoles 2a-i, which were tested on human farnesyltransferase and on the NCI-60 human tumor cell lines. Synthesis of other dimethoxytriazine derivatives 15 and 16, linked to a sp 2 or a sp 3 carbon atom were also studied. Electronic supplementary material The online version of this article (2a-i target compounds CO 2 H 2c: IC 50 (human FTase) = 38.6 µM

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Besseres Darstellungsverfahren für Mononatrium‐cyanamid

Cited by 13 publications

References 0 publications

Anion Coordination Chemistry: Polyguanidinium Salts as Anion Complexones

Anion Coordination Chemistry: Polyguanidinium Salts as Anion Complexones

A New Ligand for the Formation of Triangular Building Blocks in Supramolecular Chemistry

Synthesis and biological evaluation of a new class of triazin–triazoles as potential inhibitors of human farnesyltransferase

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