Best approach for prostate cancer detection: a prospective study on transperineal versus transrectal six-core prostate biopsy

Emiliozzi, P.; Corsetti, Adriana; Tassi, B; Federico, Giorgio; Moscarelli, Marco; Pansadoro, Vito

doi:10.1016/s0090-4295(02)02551-7

Cited by 120 publications

(70 citation statements)

References 21 publications

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“…Comparing the efficacy of transperineal versus transrectal biopsy, the core number seems to be important to increase the cancer detection rate. Emiliozzi et al reported that transperineal 6-core biopsy was superior to transrectal 6-core biopsy to detect cancer [28] , whereas a recent report showed no statistical difference in cancer detection rate or in the characteristics of detected cancers between transrectal 12-core and transperineal 14-core biopsy [29] . Furthermore, to improve cancer detection, extensive 12-core biopsy using a combined transperineal and transrectal approach has been proposed, especially in patients with PSA level in the gray zone [3] .…”

Section: Discussionmentioning

confidence: 98%

Free PSA/Total PSA Ratio Increases the Detection Rate of Prostate Cancer in Twelve-Core Biopsy

Yokomizo¹,

Miyoshi²,

Nakaigawa³

et al. 2009

Urol Int

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Background: In the present study, we compared 12- with 8-core biopsy in patients with prostate-specific antigen (PSA) levels of 4.0–20.0 ng/ml. We also examined whether the free/total (F/T) PSA ratio is useful for cancer detection in 12-core biopsy. Methods: A total of 419 men with PSA level between 4.0 and 20.0 ng/ml underwent transrectal ultrasound-guided transperineal needle biopsies of the prostate. Of these men, 235 underwent 8-core biopsy and 184 underwent 12-core biopsy. We compared the cancer detection rate between the 8- and 12-core biopsy groups by analyzing the PSA value, and especially the F/T PSA ratio. Results: The cancer detection rate in the 12-core group (35.9%) was significantly higher than in the 8-core group (23.8%). In cases of PSA level of 4.0–20.0 ng/ml with F/T PSA ratio less than 0.11, the cancer detection rate was 53.1% in the 12-core biopsy group. Performing 12-core biopsy resulted in a marked difference of cancer detection rate between men with F/T PSA ratio less than 0.11 and those with more than 0.12 in gray zone PSA (48.2% and 17.5%, respectively). Conclusions: Twelve-core biopsy can achieve a higher detection rate of prostate cancer than 8-core biopsy using F/T PSA ratio.

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Section: Discussionmentioning

confidence: 98%

Free PSA/Total PSA Ratio Increases the Detection Rate of Prostate Cancer in Twelve-Core Biopsy

Yokomizo¹,

Miyoshi²,

Nakaigawa³

et al. 2009

Urol Int

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“…On the other hand, the TP method missed two cancers located at the prostatic base. Emiliozzi et al 13 performed prostate biopsy with six TP cores plus six TR cores in a prospective study. Of the 43 who were diagnosed cancer, 41 (95%) were detected by the TP approach and 34 (79%) by the TR approach (P ¼ 0.012).…”

Section: Discussionmentioning

confidence: 99%

A prospective randomized comparison of diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy

Takenaka

Hara

Ishimura

et al. 2007

Prostate Cancer Prostatic Dis

116

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The aim of this study is to elucidate the diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy for prostate cancer. We prospectively randomized 200 consecutive men into two groups to undergo systematic prostate biopsy. Overall positivity for cancer was similar (47% by transperineal and 53% by transrectal; P ¼ 0.480). However, in case with 'gray zone' PSA (from 4.1 to 10.0 ng/ml), significantly more cores were positive when approach was transperineal, especially among transition zone cores. Therefore, urologist preferences are sufficient for choosing an approach, except for a possible small advantage of transperineal biopsy when PSA is in gray zone.

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“…In a direct comparison between the two approaches, Kawakami and associates 20 found no significance differences in the ability to detect and characterize PCa in contrast with Emiliozzi and coworkers, 21 who reported on superiority of the TP approach. The conflicting conclusions reached by these investigators may be, at least in part, because of the different number of cores taken; while Emiliozzi and colleagues 21 reported on six cores by each approach, Kawakami and coworkers 20 obtained 12 and 14 cores by TR and TP approaches, respectively. These findings may suggest that the superiority of TP over the TR approach in detecting PCa may vanish when the number of cores is increased.…”

Section: Transrectal (Tr) or Tp?mentioning

confidence: 95%

Prostate Biopsy in Selecting Candidates for Hemiablative Focal Therapy

Tsivian

Hruza²,

Mouraviev³

et al. 2010

Journal of Endourology

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Focal therapy (FT) for the management of clinically localized prostate cancer (PCa) is growing from a concept to reality because of increased interest of both patients and physicians. Selection protocols, however, are yet to be established. We discuss the role of prostate biopsy in candidate selection for FT and highlight the different strategies and technical aspects of the use of prostate biopsy in this setting. In our opinion, prostate biopsy plays a major role in the selection process and tailoring appropriate treatment strategy to the patient. FT necessitates dedicated biopsy schemes that would reliably predict the extent, nature, and location of PCa in selected patients. Currently, there is insufficient scientific evidence to propose a specific biopsy scheme that could fit every candidate, providing accurate characterization of the disease in the individual patient. Further research is necessary to establish solid selection protocols that would reliably identify appropriate candidates for FT of PCa.

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Best approach for prostate cancer detection: a prospective study on transperineal versus transrectal six-core prostate biopsy

Cited by 120 publications

References 21 publications

Free PSA/Total PSA Ratio Increases the Detection Rate of Prostate Cancer in Twelve-Core Biopsy

Free PSA/Total PSA Ratio Increases the Detection Rate of Prostate Cancer in Twelve-Core Biopsy

A prospective randomized comparison of diagnostic efficacy between transperineal and transrectal 12-core prostate biopsy

Prostate Biopsy in Selecting Candidates for Hemiablative Focal Therapy

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